Dosimetry of Photon and Proton MRI Guided Radiotherapy Beams using Silicon Array Dosimeters

The integration of online magnetic resonance imaging (MRI) with photon and pro-ton radiotherapy has potential to overcome the soft tissue contrast limitations of the current standard of care kV-image guided radiotherapy in some challenging treat-ment sites. By directly visualising soft tissue targets and organs at risk, removing the dependence on surrogates for image guidance, it is expected there will be a decrease in the geometric uncertainties related to daily patient setup. This new approach to image guided radiotherapy presents unique challenges due to the permanent mag-netic field of the integrated MRI unit. The trajectory of charged particles including dose depositing secondary electrons are perturbed by the magnetic field, adding to the challenge of calculating the patient dosimetry and validating the calculation with measurement as is standard practice in radiotherapy. The magnetic field may also effect the operation and response of radiation detectors and a method of accurately characterising the influence of the magnetic field on detector response and operation is required. This thesis reports progress made towards real time high spatial resolution dosime-try of photon and proton MRI guided radiotherapy beams using novel monolithic silicon detectors designed at the Centre for Medical Radiation Physics (CMRP). One challenge in experimentally characterising the magnetic field effects on a radiation detectors operation is how to perform dosimetry measurements with and without a magnetic field of varying strength and orientation from a single radiation source as this is not feasible on existing MRI linacs with a permanent magnetic field of fixed strength. A bespoke semi-portable magnet device was developed to meet this need. The device employs an adjustable iron yoke and focusing cones to vary the magnetic field of the central volume, a 0.3 T field can be achieved for volume to 10 x 10 x 10 cm3 and up to a 1.2 T for a volume of at least 3 x 3 x 3 cm3. The device is de-signed to be used with a clinical linear accelerator in both inline and perpendicular magnetic field orientations to meet the challenge of detector characterisation. The performance of the magnetic field generated by the device was within ±2 % of finite element modelling predictions of all configurations tested

An Abstraction Framework for Tangible Interactive Surfaces

This cumulative dissertation discusses - by the example of four subsequent publications - the various layers of a tangible interaction framework, which has been developed in conjunction with an electronic musical instrument with a tabletop tangible user interface. Based on the experiences that have been collected during the design and implementation of that particular musical application, this research mainly concentrates on the definition of a general-purpose abstraction model for the encapsulation of physical interface components that are commonly employed in the context of an interactive surface environment. Along with a detailed description of the underlying abstraction model, this dissertation also describes an actual implementation in the form of a detailed protocol syntax, which constitutes the common element of a distributed architecture for the construction of surface-based tangible user interfaces. The initial implementation of the presented abstraction model within an actual application toolkit is comprised of the TUIO protocol and the related computer-vision based object and multi-touch tracking software reacTIVision, along with its principal application within the Reactable synthesizer. The dissertation concludes with an evaluation and extension of the initial TUIO model, by presenting TUIO2 - a next generation abstraction model designed for a more comprehensive range of tangible interaction platforms and related application scenarios

High-precision Adjuvant Radiotherapy for Early-stage Breast Cancer Patients to Reduce Toxicity and Improve Survival

The risk of long-term toxicity of radiation treatment for early-stage breast cancer can be reduced by using partial breast irradiation, lungsparing and a non-coplanar beam set-up. The drift of the patient during irradaition and the motion of markers relative to the treatment target are important factors for the calculation of the margin required for partial breast irradiation

Angular variation as a monocular cue for spatial percepcion

Monocular cues are spatial sensory inputs which are picked up exclusively from one eye. They are in majority static features that provide depth information and are extensively used in graphic art to create realistic representations of a scene. Since the spatial information contained in these cues is picked up from the retinal image, the existence of a link between it and the theory of direct perception can be conveniently assumed. According to this theory, spatial information of an environment is directly contained in the optic array. Thus, this assumption makes possible the modeling of visual perception processes through computational approaches. In this thesis, angular variation is considered as a monocular cue, and the concept of direct perception is adopted by a computer vision approach that considers it as a suitable principle from which innovative techniques to calculate spatial information can be developed. The expected spatial information to be obtained from this monocular cue is the position and orientation of an object with respect to the observer, which in computer vision is a well known field of research called 2D-3D pose estimation. In this thesis, the attempt to establish the angular variation as a monocular cue and thus the achievement of a computational approach to direct perception is carried out by the development of a set of pose estimation methods. Parting from conventional strategies to solve the pose estimation problem, a first approach imposes constraint equations to relate object and image features. In this sense, two algorithms based on a simple line rotation motion analysis were developed. These algorithms successfully provide pose information; however, they depend strongly on scene data conditions. To overcome this limitation, a second approach inspired in the biological processes performed by the human visual system was developed. It is based in the proper content of the image and defines a computational approach to direct perception. The set of developed algorithms analyzes the visual properties provided by angular variations. The aim is to gather valuable data from which spatial information can be obtained and used to emulate a visual perception process by establishing a 2D-3D metric relation. Since it is considered fundamental in the visual-motor coordination and consequently essential to interact with the environment, a significant cognitive effect is produced by the application of the developed computational approach in environments mediated by technology. In this work, this cognitive effect is demonstrated by an experimental study where a number of participants were asked to complete an action-perception task. The main purpose of the study was to analyze the visual guided behavior in teleoperation and the cognitive effect caused by the addition of 3D information. The results presented a significant influence of the 3D aid in the skill improvement, which showed an enhancement of the sense of presence.Las señales monoculares son entradas sensoriales capturadas exclusivamente por un solo ojo que ayudan a la percepción de distancia o espacio. Son en su mayoría características estáticas que proveen información de profundidad y son muy utilizadas en arte gráfico para crear apariencias reales de una escena. Dado que la información espacial contenida en dichas señales son extraídas de la retina, la existencia de una relación entre esta extracción de información y la teoría de percepción directa puede ser convenientemente asumida. De acuerdo a esta teoría, la información espacial de todo le que vemos está directamente contenido en el arreglo óptico. Por lo tanto, esta suposición hace posible el modelado de procesos de percepción visual a través de enfoques computacionales. En esta tesis doctoral, la variación angular es considerada como una señal monocular, y el concepto de percepción directa adoptado por un enfoque basado en algoritmos de visión por computador que lo consideran un principio apropiado para el desarrollo de nuevas técnicas de cálculo de información espacial. La información espacial esperada a obtener de esta señal monocular es la posición y orientación de un objeto con respecto al observador, lo cual en visión por computador es un conocido campo de investigación llamado estimación de la pose 2D-3D. En esta tesis doctoral, establecer la variación angular como señal monocular y conseguir un modelo matemático que describa la percepción directa, se lleva a cabo mediante el desarrollo de un grupo de métodos de estimación de la pose. Partiendo de estrategias convencionales, un primer enfoque implanta restricciones geométricas en ecuaciones para relacionar características del objeto y la imagen. En este caso, dos algoritmos basados en el análisis de movimientos de rotación de una línea recta fueron desarrollados. Estos algoritmos exitosamente proveen información de la pose. Sin embargo, dependen fuertemente de condiciones de la escena. Para superar esta limitación, un segundo enfoque inspirado en los procesos biológicos ejecutados por el sistema visual humano fue desarrollado. Está basado en el propio contenido de la imagen y define un enfoque computacional a la percepción directa. El grupo de algoritmos desarrollados analiza las propiedades visuales suministradas por variaciones angulares. El propósito principal es el de reunir datos de importancia con los cuales la información espacial pueda ser obtenida y utilizada para emular procesos de percepción visual mediante el establecimiento de relaciones métricas 2D- 3D. Debido a que dicha relación es considerada fundamental en la coordinación visuomotora y consecuentemente esencial para interactuar con lo que nos rodea, un efecto cognitivo significativo puede ser producido por la aplicación de métodos de L estimación de pose en entornos mediados tecnológicamente. En esta tesis doctoral, este efecto cognitivo ha sido demostrado por un estudio experimental en el cual un número de participantes fueron invitados a ejecutar una tarea de acción-percepción. El propósito principal de este estudio fue el análisis de la conducta guiada visualmente en teleoperación y el efecto cognitivo causado por la inclusión de información 3D. Los resultados han presentado una influencia notable de la ayuda 3D en la mejora de la habilidad, así como un aumento de la sensación de presencia