1,094 research outputs found
A Learning Health System for Radiation Oncology
The proposed research aims to address the challenges faced by clinical data science researchers in radiation oncology accessing, integrating, and analyzing heterogeneous data from various sources. The research presents a scalable intelligent infrastructure, called the Health Information Gateway and Exchange (HINGE), which captures and structures data from multiple sources into a knowledge base with semantically interlinked entities. This infrastructure enables researchers to mine novel associations and gather relevant knowledge for personalized clinical outcomes.
The dissertation discusses the design framework and implementation of HINGE, which abstracts structured data from treatment planning systems, treatment management systems, and electronic health records. It utilizes disease-specific smart templates for capturing clinical information in a discrete manner. HINGE performs data extraction, aggregation, and quality and outcome assessment functions automatically, connecting seamlessly with local IT/medical infrastructure.
Furthermore, the research presents a knowledge graph-based approach to map radiotherapy data to an ontology-based data repository using FAIR (Findable, Accessible, Interoperable, Reusable) concepts. This approach ensures that the data is easily discoverable and accessible for clinical decision support systems. The dissertation explores the ETL (Extract, Transform, Load) process, data model frameworks, ontologies, and provides a real-world clinical use case for this data mapping.
To improve the efficiency of retrieving information from large clinical datasets, a search engine based on ontology-based keyword searching and synonym-based term matching tool was developed. The hierarchical nature of ontologies is leveraged to retrieve patient records based on parent and children classes. Additionally, patient similarity analysis is conducted using vector embedding models (Word2Vec, Doc2Vec, GloVe, and FastText) to identify similar patients based on text corpus creation methods. Results from the analysis using these models are presented.
The implementation of a learning health system for predicting radiation pneumonitis following stereotactic body radiotherapy is also discussed. 3D convolutional neural networks (CNNs) are utilized with radiographic and dosimetric datasets to predict the likelihood of radiation pneumonitis. DenseNet-121 and ResNet-50 models are employed for this study, along with integrated gradient techniques to identify salient regions within the input 3D image dataset. The predictive performance of the 3D CNN models is evaluated based on clinical outcomes.
Overall, the proposed Learning Health System provides a comprehensive solution for capturing, integrating, and analyzing heterogeneous data in a knowledge base. It offers researchers the ability to extract valuable insights and associations from diverse sources, ultimately leading to improved clinical outcomes. This work can serve as a model for implementing LHS in other medical specialties, advancing personalized and data-driven medicine
Natural language processing
Beginning with the basic issues of NLP, this chapter aims to chart the major research activities in this area since the last ARIST Chapter in 1996 (Haas, 1996), including: (i) natural language text processing systems - text summarization, information extraction, information retrieval, etc., including domain-specific applications; (ii) natural language interfaces; (iii) NLP in the context of www and digital libraries ; and (iv) evaluation of NLP systems
Semantic Interpretation of User Queries for Question Answering on Interlinked Data
The Web of Data contains a wealth of knowledge belonging to a large number of domains. Retrieving data from such precious interlinked knowledge bases is an issue. By taking the structure of data into account, it is expected that upcoming generation of search engines is approaching to question answering systems, which directly answer user questions. But developing a question answering over these interlinked data sources is still challenging because of two inherent characteristics: First, different datasets employ heterogeneous schemas and each one may only contain a part of the answer for a certain question. Second, constructing a federated formal query across different datasets requires exploiting links between these datasets on both the schema and instance levels. In this respect, several challenges such as resource disambiguation, vocabulary mismatch, inference, link traversal are raised. In this dissertation, we address these challenges in order to build a question answering system for Linked Data. We present our question answering system Sina, which transforms user-supplied queries (i.e. either natural language queries or keyword queries) into conjunctive SPARQL queries over a set of interlinked data sources. The contributions of this work are as follows: 1. A novel approach for determining the most suitable resources for a user-supplied query from different datasets (disambiguation approach). We employed a Hidden Markov Model, whose parameters were bootstrapped with different distribution functions. 2. A novel method for constructing federated formal queries using the disambiguated resources and leveraging the linking structure of the underlying datasets. This approach essentially relies on a combination of domain and range inference as well as a link traversal method for constructing a connected graph, which ultimately renders a corresponding SPARQL query. 3. Regarding the problem of vocabulary mismatch, our contribution is divided into two parts, First, we introduce a number of new query expansion features based on semantic and linguistic inferencing over Linked Data. We evaluate the effectiveness of each feature individually as well as their combinations, employing Support Vector Machines and Decision Trees. Second, we propose a novel method for automatic query expansion, which employs a Hidden Markov Model to obtain the optimal tuples of derived words. 4. We provide two benchmarks for two different tasks to the community of question answering systems. The first one is used for the task of question answering on interlinked datasets (i.e. federated queries over Linked Data). The second one is used for the vocabulary mismatch task. We evaluate the accuracy of our approach using measures like mean reciprocal rank, precision, recall, and F-measure on three interlinked life-science datasets as well as DBpedia. The results of our accuracy evaluation demonstrate the effectiveness of our approach. Moreover, we study the runtime of our approach in its sequential as well as parallel implementations and draw conclusions on the scalability of our approach on Linked Data
Advanced Knowledge Technologies at the Midterm: Tools and Methods for the Semantic Web
The University of Edinburgh and research sponsors are authorised to reproduce and distribute reprints and on-line copies for their purposes notwithstanding any copyright annotation hereon. The views and conclusions contained herein are the author’s and shouldn’t be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of other parties.In a celebrated essay on the new electronic media, Marshall McLuhan wrote in 1962:Our private senses are not closed systems but are endlessly translated into each other in that experience which we call consciousness. Our extended senses, tools, technologies, through the ages, have been closed systems incapable of interplay or collective awareness. Now, in the electric age, the very
instantaneous nature of co-existence among our technological instruments has created a crisis quite new in human history. Our extended faculties and senses now constitute a single field of experience which demands that they become collectively conscious. Our technologies, like our private senses, now demand an interplay and ratio that makes rational co-existence possible. As long as our technologies were as slow as the wheel or the alphabet or money, the fact that
they were separate, closed systems was socially and psychically supportable. This is not true now when sight and sound and movement are simultaneous and global in extent. (McLuhan 1962, p.5, emphasis in original)Over forty years later, the seamless interplay that McLuhan demanded between our
technologies is still barely visible. McLuhan’s predictions of the spread, and increased importance, of electronic media have of course been borne out, and the worlds of business, science and knowledge storage and transfer have been revolutionised. Yet
the integration of electronic systems as open systems remains in its infancy.Advanced Knowledge Technologies (AKT) aims to address this problem, to create a view of knowledge and its management across its lifecycle, to research and create the
services and technologies that such unification will require. Half way through its sixyear span, the results are beginning to come through, and this paper will explore some of the services, technologies and methodologies that have been developed. We hope to give a sense in this paper of the potential for the next three years, to discuss the insights and lessons learnt in the first phase of the project, to articulate the challenges and issues that remain.The WWW provided the original context that made the AKT approach to knowledge
management (KM) possible. AKT was initially proposed in 1999, it brought together an interdisciplinary consortium with the technological breadth and complementarity to create the conditions for a unified approach to knowledge across its lifecycle. The
combination of this expertise, and the time and space afforded the consortium by the
IRC structure, suggested the opportunity for a concerted effort to develop an approach
to advanced knowledge technologies, based on the WWW as a basic infrastructure.The technological context of AKT altered for the better in the short period between the development of the proposal and the beginning of the project itself with the development of the semantic web (SW), which foresaw much more intelligent manipulation and querying of knowledge. The opportunities that the SW provided for e.g., more intelligent retrieval, put AKT in the centre of information technology innovation and knowledge management services; the AKT skill set would clearly be central for the exploitation of those opportunities.The SW, as an extension of the WWW, provides an interesting set of constraints to
the knowledge management services AKT tries to provide. As a medium for the
semantically-informed coordination of information, it has suggested a number of ways in which the objectives of AKT can be achieved, most obviously through the
provision of knowledge management services delivered over the web as opposed to the creation and provision of technologies to manage knowledge.AKT is working on the assumption that many web services will be developed and provided for users. The KM problem in the near future will be one of deciding which services are needed and of coordinating them. Many of these services will be largely or entirely legacies of the WWW, and so the capabilities of the services will vary. As well as providing useful KM services in their own right, AKT will be aiming to exploit this opportunity, by reasoning over services, brokering between them, and providing essential meta-services for SW knowledge service management.Ontologies will be a crucial tool for the SW. The AKT consortium brings a lot of expertise on ontologies together, and ontologies were always going to be a key part of the strategy. All kinds of knowledge sharing and transfer activities will be mediated by ontologies, and ontology management will be an important enabling task. Different
applications will need to cope with inconsistent ontologies, or with the problems that will follow the automatic creation of ontologies (e.g. merging of pre-existing
ontologies to create a third). Ontology mapping, and the elimination of conflicts of
reference, will be important tasks. All of these issues are discussed along with our
proposed technologies.Similarly, specifications of tasks will be used for the deployment of knowledge services over the SW, but in general it cannot be expected that in the medium term there will be standards for task (or service) specifications. The brokering metaservices
that are envisaged will have to deal with this heterogeneity.The emerging picture of the SW is one of great opportunity but it will not be a wellordered, certain or consistent environment. It will comprise many repositories of legacy data, outdated and inconsistent stores, and requirements for common understandings across divergent formalisms. There is clearly a role for standards to play to bring much of this context together; AKT is playing a significant role in these efforts. But standards take time to emerge, they take political power to enforce, and they have been known to stifle innovation (in the short term). AKT is keen to understand the balance between principled inference and statistical processing of web content. Logical inference on the Web is tough. Complex queries using traditional AI inference methods bring most distributed computer systems to their knees. Do we set up semantically well-behaved areas of the Web? Is any part of the Web in which
semantic hygiene prevails interesting enough to reason in? These and many other
questions need to be addressed if we are to provide effective knowledge technologies
for our content on the web
Integration of distributed terminology resources to facilitate subject cross-browsing for library portal systems
With the increase in the number of distributed library information resources, users
may have to interact with different user interfaces, learn to switch their mental models
between these interfaces, and familiarise themselves with controlled vocabularies
used by different resources. For this reason, library professionals have developed
library portals to integrate these distributed information resources, and assist end-users
in cross-accessing distributed resources via a single access point in their own
library. There are two important subject-based services that a library portal system
might be able to provide. The first is a federated search service, which refers to a
process where a user can input a query to cross-search a number of information
resources. The second is a subject cross-browsing service, which can offer a
knowledge navigation tree to link subject schemes used by distributed resources.
However, the development of subject cross-searching and browsing services has been
impeded by the heterogeneity of different KOS (Knowledge Organisation System)
used by different information resources. Due to the lack of mappings between
different KOS, it is impossible to offer a subject cross-browsing service for a library
portal system. [Continues.
A semantic and agent-based approach to support information retrieval, interoperability and multi-lateral viewpoints for heterogeneous environmental databases
PhDData stored in individual autonomous databases often needs to be combined and
interrelated. For example, in the Inland Water (IW) environment monitoring domain,
the spatial and temporal variation of measurements of different water quality indicators
stored in different databases are of interest. Data from multiple data sources is more
complex to combine when there is a lack of metadata in a computation forin and when
the syntax and semantics of the stored data models are heterogeneous. The main types
of information retrieval (IR) requirements are query transparency and data
harmonisation for data interoperability and support for multiple user views. A
combined Semantic Web based and Agent based distributed system framework has
been developed to support the above IR requirements. It has been implemented using
the Jena ontology and JADE agent toolkits. The semantic part supports the
interoperability of autonomous data sources by merging their intensional data, using a
Global-As-View or GAV approach, into a global semantic model, represented in
DAML+OIL and in OWL. This is used to mediate between different local database
views. The agent part provides the semantic services to import, align and parse
semantic metadata instances, to support data mediation and to reason about data
mappings during alignment. The framework has applied to support information
retrieval, interoperability and multi-lateral viewpoints for four European environmental
agency databases.
An extended GAV approach has been developed and applied to handle queries that can
be reformulated over multiple user views of the stored data. This allows users to
retrieve data in a conceptualisation that is better suited to them rather than to have to
understand the entire detailed global view conceptualisation. User viewpoints are
derived from the global ontology or existing viewpoints of it. This has the advantage
that it reduces the number of potential conceptualisations and their associated
mappings to be more computationally manageable. Whereas an ad hoc framework
based upon conventional distributed programming language and a rule framework
could be used to support user views and adaptation to user views, a more formal
framework has the benefit in that it can support reasoning about the consistency,
equivalence, containment and conflict resolution when traversing data models. A
preliminary formulation of the formal model has been undertaken and is based upon
extending a Datalog type algebra with hierarchical, attribute and instance value
operators. These operators can be applied to support compositional mapping and
consistency checking of data views. The multiple viewpoint system was implemented
as a Java-based application consisting of two sub-systems, one for viewpoint
adaptation and management, the other for query processing and query result
adjustment
Combining semantic web technologies with evolving fuzzy classifier eClass for EHR-based phenotyping : a feasibility study
In parallel to nation-wide efforts for setting up shared electronic health records (EHRs) across healthcare settings, several large-scale national and international projects are developing, validating, and deploying electronic EHR oriented phenotype algorithms that aim at large-scale use of EHRs data for genomic studies. A current bottleneck in using EHRs data for obtaining computable phenotypes is to transform the raw EHR data into clinically relevant features. The research study presented here proposes a novel combination of Semantic Web technologies with the on-line evolving fuzzy classifier eClass to
obtain and validate EHR-driven computable phenotypes derived from 1956 clinical statements from EHRs. The evaluation performed with clinicians demonstrates the feasibility and practical acceptability of the approach proposed
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