2,479 research outputs found

    UMSL Bulletin 2023-2024

    Get PDF
    The 2023-2024 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1088/thumbnail.jp

    LIPIcs, Volume 251, ITCS 2023, Complete Volume

    Get PDF
    LIPIcs, Volume 251, ITCS 2023, Complete Volum

    UMSL Bulletin 2022-2023

    Get PDF
    The 2022-2023 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1087/thumbnail.jp

    AI-based design methodologies for hot form quench (HFQ®)

    Get PDF
    This thesis aims to develop advanced design methodologies that fully exploit the capabilities of the Hot Form Quench (HFQ®) stamping process in stamping complex geometric features in high-strength aluminium alloy structural components. While previous research has focused on material models for FE simulations, these simulations are not suitable for early-phase design due to their high computational cost and expertise requirements. This project has two main objectives: first, to develop design guidelines for the early-stage design phase; and second, to create a machine learning-based platform that can optimise 3D geometries under hot stamping constraints, for both early and late-stage design. With these methodologies, the aim is to facilitate the incorporation of HFQ capabilities into component geometry design, enabling the full realisation of its benefits. To achieve the objectives of this project, two main efforts were undertaken. Firstly, the analysis of aluminium alloys for stamping deep corners was simplified by identifying the effects of corner geometry and material characteristics on post-form thinning distribution. New equation sets were proposed to model trends and design maps were created to guide component design at early stages. Secondly, a platform was developed to optimise 3D geometries for stamping, using deep learning technologies to incorporate manufacturing capabilities. This platform combined two neural networks: a geometry generator based on Signed Distance Functions (SDFs), and an image-based manufacturability surrogate model. The platform used gradient-based techniques to update the inputs to the geometry generator based on the surrogate model's manufacturability information. The effectiveness of the platform was demonstrated on two geometry classes, Corners and Bulkheads, with five case studies conducted to optimise under post-stamped thinning constraints. Results showed that the platform allowed for free morphing of complex geometries, leading to significant improvements in component quality. The research outcomes represent a significant contribution to the field of technologically advanced manufacturing methods and offer promising avenues for future research. The developed methodologies provide practical solutions for designers to identify optimal component geometries, ensuring manufacturing feasibility and reducing design development time and costs. The potential applications of these methodologies extend to real-world industrial settings and can significantly contribute to the continued advancement of the manufacturing sector.Open Acces

    Laser Technologies for Applications in Quantum Information Science

    Get PDF
    Scientific progress in experimental physics is inevitably dependent on continuing advances in the underlying technologies. Laser technologies enable controlled coherent and dissipative atom-light interactions and micro-optical technologies allow for the implementation of versatile optical systems not accessible with standard optics. This thesis reports on important advances in both technologies with targeted applications ranging from Rydberg-state mediated quantum simulation and computation with individual atoms in arrays of optical tweezers to high-resolution spectroscopy of highly-charged ions. A wide range of advances in laser technologies are reported: The long-term stability and maintainability of external-cavity diode laser systems is improved significantly by introducing a mechanically adjustable lens mount. Tapered-amplifier modules based on a similar lens mount are developed. The diode laser systems are complemented by digital controllers for laser frequency and intensity stabilisation. The controllers offer a bandwidth of up to 1.25 MHz and a noise performance set by the commercial STEMlab platform. In addition, shot-noise limited photodetectors optimised for intensity stabilisation and Pound-Drever-Hall frequency stabilisation as well as a fiber based detector for beat notes in the MHz-regime are developed. The capabilities of the presented techniques are demonstrated by analysing the performance of a laser system used for laser cooling of Rb85 at a wavelength of 780 nm. A reference laser system is stabilised to a spectroscopic reference provided by modulation transfer spectroscopy. This spectroscopy scheme is analysed finding optimal operation at high modulation indices. A suitable signal is generated with a compact and cost-efficient module. A scheme for laser offset-frequency stabilisation based on an optical phase-locked loop is realised. All frequency locks derived from the reference laser system offer a Lorentzian linewidth of 60 kHz (FWHM) in combination with a long-term stability of 130 kHz peak-to-peak within 10 days. Intensity stabilisation based on acousto-optic modulators in combination with the digital controller allows for real-time intensity control on microsecond time scales complemented by a sample and hold feature with a response time of 150 ns. High demands on the spectral properties of the laser systems are put forward for the coherent excitation of quantum states. In this thesis, the performance of active frequency stabilisation is enhanced by introducing a novel current modulation technique for diode lasers. A flat response from DC to 100 MHz and a phase lag below 90° up to 25 MHz are achieved extending the bandwidth available for laserfrequency stabilisation. Applying this technique in combination with a fast proportional-derivative controller, two laser fields with a relative phase noise of 42 mrad for driving rubidium ground state transitions are realised. A laser system for coherent Rydberg excitation via a two-photon scheme provides light at 780 nm and at 480 nm via frequency-doubling from 960 nm. An output power of 0.6 W at 480 nm from a single-mode optical fiber is obtained . The frequencies of both laser systems are stabilised to a high-finesse reference cavity resulting in a linewidth of 1.02 kHz (FWHM) at 960 nm. Numerical simulations quantify the effect of the finite linewidth on the coherence of Rydberg Rabi-oscillations. A laser system similar to the 480 nm Rydberg system is developed for spectroscopy on highly charged bismuth. Advanced optical technologies are also at the heart of the micro-optical generation of tweezer arrays that offer unprecedented scalability of the system size. By using an optimised lens system in combination with an automatic evaluation routine, a tweezer array with several thousand sites and trap waists below 1 μm is demonstrated. A similar performance is achieved with a microlens array produced in an additive manufacturing process. The microlens design is optimised for the manufacturing process. Furthermore, scattering rates in dipole traps due to suppressed resonant light are analysed proving the feasibility of dipole trap generation using tapered amplifier systems

    Exploration autonome et efficiente de chantiers miniers souterrains inconnus avec un drone filaire

    Get PDF
    Abstract: Underground mining stopes are often mapped using a sensor located at the end of a pole that the operator introduces into the stope from a secure area. The sensor emits laser beams that provide the distance to a detected wall, thus creating a 3D map. This produces shadow zones and a low point density on the distant walls. To address these challenges, a research team from the Université de Sherbrooke is designing a tethered drone equipped with a rotating LiDAR for this mission, thus benefiting from several points of view. The wired transmission allows for unlimited flight time, shared computing, and real-time communication. For compatibility with the movement of the drone after tether entanglements, the excess length is integrated into an onboard spool, contributing to the drone payload. During manual piloting, the human factor causes problems in the perception and comprehension of a virtual 3D environment, as well as the execution of an optimal mission. This thesis focuses on autonomous navigation in two aspects: path planning and exploration. The system must compute a trajectory that maps the entire environment, minimizing the mission time and respecting the maximum onboard tether length. Path planning using a Rapidly-exploring Random Tree (RRT) quickly finds a feasible path, but the optimization is computationally expensive and the performance is variable and unpredictable. Exploration by the frontier method is representative of the space to be explored and the path can be optimized by solving a Traveling Salesman Problem (TSP) but existing techniques for a tethered drone only consider the 2D case and do not optimize the global path. To meet these challenges, this thesis presents two new algorithms. The first one, RRT-Rope, produces an equal or shorter path than existing algorithms in a significantly shorter computation time, up to 70% faster than the next best algorithm in a representative environment. A modified version of RRT-connect computes a feasible path, shortened with a deterministic technique that takes advantage of previously added intermediate nodes. The second algorithm, TAPE, is the first 3D cavity exploration method that focuses on minimizing mission time and unwound tether length. On average, the overall path is 4% longer than the method that solves the TSP, but the tether remains under the allowed length in 100% of the simulated cases, compared to 53% with the initial method. The approach uses a 2-level hierarchical architecture: global planning solves a TSP after frontier extraction, and local planning minimizes the path cost and tether length via a decision function. The integration of these two tools in the NetherDrone produces an intelligent system for autonomous exploration, with semi-autonomous features for operator interaction. This work opens the door to new navigation approaches in the field of inspection, mapping, and Search and Rescue missions.La cartographie des chantiers miniers souterrains est souvent réalisée à l’aide d’un capteur situé au bout d’une perche que l’opérateur introduit dans le chantier, depuis une zone sécurisée. Le capteur émet des faisceaux laser qui fournissent la distance à un mur détecté, créant ainsi une carte en 3D. Ceci produit des zones d’ombres et une faible densité de points sur les parois éloignées. Pour relever ces défis, une équipe de recherche de l’Université de Sherbrooke conçoit un drone filaire équipé d’un LiDAR rotatif pour cette mission, bénéficiant ainsi de plusieurs points de vue. La transmission filaire permet un temps de vol illimité, un partage de calcul et une communication en temps réel. Pour une compatibilité avec le mouvement du drone lors des coincements du fil, la longueur excédante est intégrée dans une bobine embarquée, qui contribue à la charge utile du drone. Lors d’un pilotage manuel, le facteur humain entraîne des problèmes de perception et compréhension d’un environnement 3D virtuel, et d’exécution d’une mission optimale. Cette thèse se concentre sur la navigation autonome sous deux aspects : la planification de trajectoire et l’exploration. Le système doit calculer une trajectoire qui cartographie l’environnement complet, en minimisant le temps de mission et en respectant la longueur maximale de fil embarquée. La planification de trajectoire à l’aide d’un Rapidly-exploring Random Tree (RRT) trouve rapidement un chemin réalisable, mais l’optimisation est coûteuse en calcul et la performance est variable et imprévisible. L’exploration par la méthode des frontières est représentative de l’espace à explorer et le chemin peut être optimisé en résolvant un Traveling Salesman Problem (TSP), mais les techniques existantes pour un drone filaire ne considèrent que le cas 2D et n’optimisent pas le chemin global. Pour relever ces défis, cette thèse présente deux nouveaux algorithmes. Le premier, RRT-Rope, produit un chemin égal ou plus court que les algorithmes existants en un temps de calcul jusqu’à 70% plus court que le deuxième meilleur algorithme dans un environnement représentatif. Une version modifiée de RRT-connect calcule un chemin réalisable, raccourci avec une technique déterministe qui tire profit des noeuds intermédiaires préalablement ajoutés. Le deuxième algorithme, TAPE, est la première méthode d’exploration de cavités en 3D qui minimise le temps de mission et la longueur du fil déroulé. En moyenne, le trajet global est 4% plus long que la méthode qui résout le TSP, mais le fil reste sous la longueur autorisée dans 100% des cas simulés, contre 53% avec la méthode initiale. L’approche utilise une architecture hiérarchique à 2 niveaux : la planification globale résout un TSP après extraction des frontières, et la planification locale minimise le coût du chemin et la longueur de fil via une fonction de décision. L’intégration de ces deux outils dans le NetherDrone produit un système intelligent pour l’exploration autonome, doté de fonctionnalités semi-autonomes pour une interaction avec l’opérateur. Les travaux réalisés ouvrent la porte à de nouvelles approches de navigation dans le domaine des missions d’inspection, de cartographie et de recherche et sauvetage

    2017 GREAT Day Program

    Get PDF
    SUNY Geneseo’s Eleventh Annual GREAT Day.https://knightscholar.geneseo.edu/program-2007/1011/thumbnail.jp

    Computational Approaches to Drug Profiling and Drug-Protein Interactions

    Get PDF
    Despite substantial increases in R&D spending within the pharmaceutical industry, denovo drug design has become a time-consuming endeavour. High attrition rates led to a long period of stagnation in drug approvals. Due to the extreme costs associated with introducing a drug to the market, locating and understanding the reasons for clinical failure is key to future productivity. As part of this PhD, three main contributions were made in this respect. First, the web platform, LigNFam enables users to interactively explore similarity relationships between ‘drug like’ molecules and the proteins they bind. Secondly, two deep-learning-based binding site comparison tools were developed, competing with the state-of-the-art over benchmark datasets. The models have the ability to predict offtarget interactions and potential candidates for target-based drug repurposing. Finally, the open-source ScaffoldGraph software was presented for the analysis of hierarchical scaffold relationships and has already been used in multiple projects, including integration into a virtual screening pipeline to increase the tractability of ultra-large screening experiments. Together, and with existing tools, the contributions made will aid in the understanding of drug-protein relationships, particularly in the fields of off-target prediction and drug repurposing, helping to design better drugs faster

    Modern meat: the next generation of meat from cells

    Get PDF
    Modern Meat is the first textbook on cultivated meat, with contributions from over 100 experts within the cultivated meat community. The Sections of Modern Meat comprise 5 broad categories of cultivated meat: Context, Impact, Science, Society, and World. The 19 chapters of Modern Meat, spread across these 5 sections, provide detailed entries on cultivated meat. They extensively tour a range of topics including the impact of cultivated meat on humans and animals, the bioprocess of cultivated meat production, how cultivated meat may become a food option in Space and on Mars, and how cultivated meat may impact the economy, culture, and tradition of Asia

    Examining the Relationship Between Lignocellulosic Biomass Structural Constituents and Its Flow Behavior

    Get PDF
    Lignocellulosic biomass material sourced from plants and herbaceous sources is a promising substrate of inexpensive, abundant, and potentially carbon-neutral energy. One of the leading limitations of using lignocellulosic biomass as a feedstock for bioenergy products is the flow issues encountered during biomass conveyance in biorefineries. In the biorefining process, the biomass feedstock undergoes flow through a variety of conveyance systems. The inherent variability of the feedstock materials, as evidenced by their complex microstructural composition and non-uniform morphology, coupled with the varying flow conditions in the conveyance systems, gives rise to flow issues such as bridging, ratholing, and clogging. These issues slow down the conveyance process, affect machine life, and potentially lead to partial or even complete shutdown of the biorefinery. Hence, we need to improve our fundamental understanding of biomass feedstock flow physics and mechanics to address the flow issues and improve biorefinery economics. This dissertation research examines the fundamental relationship between structural constituents of diverse lignocellulosic biomass materials, i.e., cellulose, hemicellulose, and lignin, their morphology, and the impact of the structural composition and morphology on their flow behavior. First, we prepared and characterized biomass feedstocks of different chemical compositions and morphologies. Then, we conducted our fundamental investigation experimentally, through physical flow characterization tests, and computationally through high-fidelity discrete element modeling. Finally, we statistically analyzed the relative influence of the properties of lignocellulosic biomass assemblies on flow behavior to determine the most critical properties and the optimum values of flow parameters. Our research provides an experimental and computational framework to generalize findings to a wider portfolio of biomass materials. It will help the bioenergy community to design more efficient biorefining machinery and equipment, reduce the risk of failure, and improve the overall commercial viability of the bioenergy industry
    • …
    corecore