Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Computing server power modeling in a data center: survey,taxonomy and performance evaluation

Data centers are large scale, energy-hungry infrastructure serving the increasing computational demands as the world is becoming more connected in smart cities. The emergence of advanced technologies such as cloud-based services, internet of things (IoT) and big data analytics has augmented the growth of global data centers, leading to high energy consumption. This upsurge in energy consumption of the data centers not only incurs the issue of surging high cost (operational and maintenance) but also has an adverse effect on the environment. Dynamic power management in a data center environment requires the cognizance of the correlation between the system and hardware level performance counters and the power consumption. Power consumption modeling exhibits this correlation and is crucial in designing energy-efficient optimization strategies based on resource utilization. Several works in power modeling are proposed and used in the literature. However, these power models have been evaluated using different benchmarking applications, power measurement techniques and error calculation formula on different machines. In this work, we present a taxonomy and evaluation of 24 software-based power models using a unified environment, benchmarking applications, power measurement technique and error formula, with the aim of achieving an objective comparison. We use different servers architectures to assess the impact of heterogeneity on the models' comparison. The performance analysis of these models is elaborated in the paper