423 research outputs found

    Toward a Universal Theory of Stable Evolution

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    The backbone of nonequilibrium thermodynamics is the stability structure, where entropy is related to a Lyapunov function of thermodynamic equilibrium. Stability is the background of natural selection: unstable systems are temporary, and stable ones survive. The physical concepts from the stability structure and the related formalism of constrained entropy inequality are universal by construction. Therefore, the mathematical tools and the physical concepts of thermodynamics help formulate dynamical theories of any systems in social and natural sciences.Comment: 17 pages, 3 figure

    Coarse-grained modelling of blood cell mechanics

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    This thesis concerns development of mechanically realistic in silico representations of human blood cells using coarse-grained molecular dynamics (CGMD), ultimately building a new model for a lymphocyte-class white blood cell (WBC). This development is approached successively, evaluated through simulation of experimental testing methods common to past in vitro studies on blood cell mechanics. Considering both their biophysical simplicity and the extensive associated literature, the red blood cell (RBC) is first considered. As a foundation, I thus used the CGMD RBC model of Fu et al. [Lennard-Jones type pair-potential method for coarse-grained lipid bilayer membrane simulations in LAMMPS, Fu et al., Comput. Phys. Commun., 210, 193-203 (2017)]. Chapter 3 establishes implementation of this model, and in silico implementations of the three chosen testing methods. In doing so, the first quantitative assessment of the "miniature cell" approach is conducted - being the down-scaling of the physical cell size to make feasible simulation times, as was done in the original article presenting the model. The RBC model is then used as a foundation from which to develop a new whole-cell WBC lymphocyte model. This is approached sequentially. Firstly (Chapter 4), the morphology and mechanics relevant to the existing RBC model are adapted to those of a lymphocyte. As such, a quasi-spherical morphology is induced, and elastic membrane-associated parameters brought in line with the literature on isolated lymphocytes in vitro. A semi-rigid nucleus is then added to the cell interior, again parameterised to produce elastic properties consistent with the literature. These developments produce a cell having macroscopic mechanical properties much more consistent with a WBC, with an "optimal" parameterisation established. After the membrane and nucleus, the entity most influential to the mechanics of nucleated cells (such as WBC) is their complex intracellular actin-based cytoskeleton (CSK). Therefore, Chapter 5 attempts to represent such a system within our new lymphocyte model. This is approached in three successive stages, assessed against recognised CSK mechanical properties, in particular those also common to soft glassy materials. As such, a novel CSK representation is developed, inspired as a discretisation of soft glassy rheology (SGR). It is proposed that the resulting system has characteristics comparable to having undergone a glass-like transition, as relatable to a real CSK. Therefore, the resulting lymphocyte model may lay a foundation for future development towards mechanically accurate representations of other cells - in particular, a circulating tumour cell

    CRYSTAL23

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    AIMETA 2005. Atti del XVII Congresso dell'Associazione italiana di meccanica teorica e applicata. Firenze, 11-15 settembre 2005

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    The volume collects the contributions presented at the XVII national congress of AIMETA. The contributions are grouped according to the various sectors of theoretical and applied mechanics and are offered by a vast scientific community. In addition to the classical sectors, themes of interdisciplinary significance and of considerable interest and highly innovative content were added, for the analysis of which small exchange symposia were proposed. Organised according to 52 sessions (plenary and parallel), the volume contains 290 scientific works that are mainly the result of international cooperation. Therefore, the work represents a significant picture of the current situation and future prospects for mechanics

    Computational Modelling of Concrete and Concrete Structures

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    Computational Modelling of Concrete and Concrete Structures contains the contributions to the EURO-C 2022 conference (Vienna, Austria, 23-26 May 2022). The papers review and discuss research advancements and assess the applicability and robustness of methods and models for the analysis and design of concrete, fibre-reinforced and prestressed concrete structures, as well as masonry structures. Recent developments include methods of machine learning, novel discretisation methods, probabilistic models, and consideration of a growing number of micro-structural aspects in multi-scale and multi-physics settings. In addition, trends towards the material scale with new fibres and 3D printable concretes, and life-cycle oriented models for ageing and durability of existing and new concrete infrastructure are clearly visible. Overall computational robustness of numerical predictions and mathematical rigour have further increased, accompanied by careful model validation based on respective experimental programmes. The book will serve as an important reference for both academics and professionals, stimulating new research directions in the field of computational modelling of concrete and its application to the analysis of concrete structures. EURO-C 2022 is the eighth edition of the EURO-C conference series after Innsbruck 1994, Bad Gastein 1998, St. Johann im Pongau 2003, Mayrhofen 2006, Schladming 2010, St. Anton am Arlberg 2014, and Bad Hofgastein 2018. The overarching focus of the conferences is on computational methods and numerical models for the analysis of concrete and concrete structures
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