High-Frequency network activity, global increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures In Vitro

How seizures start is a major question in epilepsy research. Preictal EEG changes occur in both human patients and animal models, but their underlying mechanisms and relationship with seizure initiation remain unknown. Here we demonstrate the existence, in the hippocampal CA1 region, of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) (100 Hz) and reduction in system complexity.HFAis generated by the firing of neurons, mainly pyramidal cells, at much lower frequencies. Individual cycles ofHFAare generated by the near-synchronous (within 5 ms) firing of small numbers of pyramidal cells. The presence of HFA in the low-calcium model implicates nonsynaptic synchronization; the presence of very similar HFA in the high-potassium model shows that it does not depend on an absence of synaptic transmission. Immediately before seizure onset, CA1 is in a state of high sensitivity in which weak depolarizing or synchronizing perturbations can trigger seizures. Transition to seizure is haracterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure

Adaptive data synchronization algorithm for IoT-oriented low-power wide-area networks

The Internet of Things (IoT) is by now very close to be realized, leading the world towards a new technological era where people’s lives and habits will be definitively revolutionized. Furthermore, the incoming 5G technology promises significant enhancements concerning the Quality of Service (QoS) in mobile communications. Having billions of devices simultaneously connected has opened new challenges about network management and data exchange rules that need to be tailored to the characteristics of the considered scenario. A large part of the IoT market is pointing to Low-Power Wide-Area Networks (LPWANs) representing the infrastructure for several applications having energy saving as a mandatory goal besides other aspects of QoS. In this context, we propose a low-power IoT-oriented file synchronization protocol that, by dynamically optimizing the amount of data to be transferred, limits the device level of interaction within the network, therefore extending the battery life. This protocol can be adopted with different Layer 2 technologies and provides energy savings at the IoT device level that can be exploited by different applications

Synchronization in random networks with given expected degree sequences

Synchronization in random networks with given expected degree sequences is studied. We also investigate in details the synchronization in networks whose topology is described by classical random graphs, power-law random graphs and hybrid graphs when N goes to infinity. In particular, we show that random graphs almost surely synchronize. We also show that adding small number of global edges to a local graph makes the corresponding hybrid graph to synchroniz

Contribution to Efficient Use of Narrowband Radio Channel

Předkládaná práce se soustředí na problematiku využívání úzkopásmového rádiového kanálu rádiovými modemy, které jsou určené pro průmyslové aplikace pozemní pohyblivé rádiové služby, specifikované v dominantní míře Evropským standardem ETSI EN 300 113. Tato rádiová zařízení se používají v kmitočtových pásmech od 30 MHz do 1 GHz s nejčastěji přidělovanou šířkou pásma 25 kHz a ve většině svých instalací jsou využívána ve fixních nebo mobilních bezdrátových sítích. Mezi typické oblasti použití patří zejména datová telemetrie, aplikace typu SCADA, nebo monitorování transportu strategických surovin. Za hlavní znaky popisovaného systému lze označit komunikační pokrytí značných vzdáleností, dané především vysokou výkonovou účinnosti datového přenosu a využívaní efektivních přístupových technik na rádiový kanál se semiduplexním komunikačním režimem. Striktní požadavky na elektromagnetickou kompatibilitu umožňují těmto zařízením využívat spektrum i v oblastech kmitočtově blízkým jiným komunikačním systémům bez nutnosti vkládání dodatečných ochranných frekvenčních pásem. Úzkopásmové rádiové komunikační systémy, v současnosti používají převážně exponenciální digitální modulace s konstantní modulační obálkou zejména z důvodů velice striktních omezení pro velikost výkonu vyzářeného do sousedního kanálu. Dosahují tak pouze kompromisních hodnot komunikační účinnosti. Úpravy limitů příslušných rádiových parametrů a rychlý rozvoj prostředků číslicového zpracování signálu v nedávné době, dnes umožňují ekonomicky přijatelné využití spektrálně efektivnějších modulačních technik i v těch oblastech, kde je prioritní využívání úzkých rádiových kanálů. Cílem předkládané disertační práce je proto výzkum postupů směřující ke sjednocení výhodných vlastností lineárních a nelineárních modulací v moderní konstrukci úzkopásmového rádiového modemu. Účelem tohoto výzkumu je efektivní a „ekologické“ využívání přidělené části frekvenčního spektra. Mezi hlavní dílčí problémy, jimiž se předkládaná práce zabývá, lze zařadit zejména tyto: Nyquistova modulační filtrace, navrhovaná s ohledem na minimalizaci nežádoucích elektromagnetických interferencí, efektivní číslicové algoritmy frekvenční demodulace a rychlé rámcové a symbolové synchronizace. Součástí práce je dále analýza navrhovaného řešení z pohledu celkové konstrukce programově definovaného rádiového modemu v rovině simulací při vyšetřování robustnosti datového přenosu rádiovým kanálem s bílým Gaussovským šumem nebo kanálem s únikem v důsledku mnohacestného šíření signálu. Závěr práce je pak zaměřen na prezentování výsledků praktické části projektu, v níž byly testovány, měřeny a analyzovány dvě prototypové konstrukce rádiového zařízení. Tato finální část práce obsahuje i praktická doporučení, vedoucí k vyššímu stupni využitelnosti spektrálně efektivnějších komunikačních režimů v oblasti budoucí generace úzkopásmových zařízení pozemní pohyblivé rádiové služby.he industrial narrowband land mobile radio (LMR) devices, as considered in this dissertation project, has been subject to European standard ETSI EN 300 113. The system operates on frequencies between 30 MHz and 1 GHz, with channel separations of up to 25 kHz, and is intended for private, fixed, or mobile, radio packet switching networks. Data telemetry, SCADA, maritime and police radio services; traffic monitoring; gas, water, and electricity producing factories are the typical system applications. Long distance coverage, high power efficiency, and efficient channel access techniques in half duplex operation are the primary advantages the system relays on. Very low level of adjacent channel power emissions and robust radio receiver architectures, with high dynamic range, enable for a system’s coexistence with various communication standards, without the additional guard band frequency intervals. On the other hand, the strict limitations of the referenced standard as well as the state of the technology, has hindered the increase in communication efficiency, with which the system has used its occupied bandwidth. New modifications and improvements are needed to the standard itself and to the up-to-date architectures of narrowband LMR devices, to make the utilization of more efficient modes of system operation practically realizable. The main objective of this dissertation thesis is therefore to find a practical way how to combine the favorable properties of the advanced nonlinear and linear digital modulation techniques in a single digital modem solution, in order to increase the efficiency of the narrowband radio channel usage allocated to the new generation of the industrial LMR devices. The main attention is given to the particular areas of digital modem design such as proposal of the new family of the Nyquist filters minimizing the adjacent channel interference, design and analysis of the efficient algorithms for frequency discrimination, fast frame and symbol

A 1-bit Synchronization Algorithm for a Reduced Complexity Energy Detection UWB Receiver

This work investigates the possibility of performing synchronization in a reduced complexity Energy Detection receiver. A new receiver scheme employing a single comparator only is defined and the related synchronization algorithm is presented. The possibility of synchronizing has been analyzed both for an idealized Dirac Delta input signal and for realistic UWB signals obtained through the TG4a channel model. The matlab simulations show that it is possible to obtain coarse synchronization using a simple maximum detection algorithm computed on collected energies for the ideal case of Dirac Delta pulses. For realistic UWB signals better synchronization performances are possible by employing a searchback algorithm. Due to the low complexity of the receiver scheme, the synchronization algorithm requires a long locking time

Implementation of Time-Delay Interferometry for LISA

We discuss the baseline optical configuration for the Laser Interferometer Space Antenna (LISA) mission, in which the lasers are not free-running, but rather one of them is used as the main frequency reference generator (the {\it master}) and the remaining five as {\it slaves}, these being phase-locked to the master (the {\it master-slave configuration}). Under the condition that the frequency fluctuations due to the optical transponders can be made negligible with respect to the secondary LISA noise sources (mainly proof-mass and shot noises), we show that the entire space of interferometric combinations LISA can generate when operated with six independent lasers (the {\it one-way method}) can also be constructed with the {\it master-slave} system design. The corresponding hardware trade-off analysis for these two optical designs is presented, which indicates that the two sets of systems needed for implementing the {\it one-way method}, and the {\it master-slave configuration}, are essentially identical. Either operational mode could therefore be implemented without major implications on the hardware configuration. We then.......Comment: 39 pages, 6 figures, 2 table

Multilayer Networks

In most natural and engineered systems, a set of entities interact with each other in complicated patterns that can encompass multiple types of relationships, change in time, and include other types of complications. Such systems include multiple subsystems and layers of connectivity, and it is important to take such "multilayer" features into account to try to improve our understanding of complex systems. Consequently, it is necessary to generalize "traditional" network theory by developing (and validating) a framework and associated tools to study multilayer systems in a comprehensive fashion. The origins of such efforts date back several decades and arose in multiple disciplines, and now the study of multilayer networks has become one of the most important directions in network science. In this paper, we discuss the history of multilayer networks (and related concepts) and review the exploding body of work on such networks. To unify the disparate terminology in the large body of recent work, we discuss a general framework for multilayer networks, construct a dictionary of terminology to relate the numerous existing concepts to each other, and provide a thorough discussion that compares, contrasts, and translates between related notions such as multilayer networks, multiplex networks, interdependent networks, networks of networks, and many others. We also survey and discuss existing data sets that can be represented as multilayer networks. We review attempts to generalize single-layer-network diagnostics to multilayer networks. We also discuss the rapidly expanding research on multilayer-network models and notions like community structure, connected components, tensor decompositions, and various types of dynamical processes on multilayer networks. We conclude with a summary and an outlook.Comment: Working paper; 59 pages, 8 figure

Multicore-optimized wavefront diamond blocking for optimizing stencil updates

The importance of stencil-based algorithms in computational science has focused attention on optimized parallel implementations for multilevel cache-based processors. Temporal blocking schemes leverage the large bandwidth and low latency of caches to accelerate stencil updates and approach theoretical peak performance. A key ingredient is the reduction of data traffic across slow data paths, especially the main memory interface. In this work we combine the ideas of multi-core wavefront temporal blocking and diamond tiling to arrive at stencil update schemes that show large reductions in memory pressure compared to existing approaches. The resulting schemes show performance advantages in bandwidth-starved situations, which are exacerbated by the high bytes per lattice update case of variable coefficients. Our thread groups concept provides a controllable trade-off between concurrency and memory usage, shifting the pressure between the memory interface and the CPU. We present performance results on a contemporary Intel processor