An Infinitesimal Probabilistic Model for Principal Component Analysis of Manifold Valued Data

We provide a probabilistic and infinitesimal view of how the principal component analysis procedure (PCA) can be generalized to analysis of nonlinear manifold valued data. Starting with the probabilistic PCA interpretation of the Euclidean PCA procedure, we show how PCA can be generalized to manifolds in an intrinsic way that does not resort to linearization of the data space. The underlying probability model is constructed by mapping a Euclidean stochastic process to the manifold using stochastic development of Euclidean semimartingales. The construction uses a connection and bundles of covariant tensors to allow global transport of principal eigenvectors, and the model is thereby an example of how principal fiber bundles can be used to handle the lack of global coordinate system and orientations that characterizes manifold valued statistics. We show how curvature implies non-integrability of the equivalent of Euclidean principal subspaces, and how the stochastic flows provide an alternative to explicit construction of such subspaces. We describe estimation procedures for inference of parameters and prediction of principal components, and we give examples of properties of the model on embedded surfaces

Vaccine Access and Affordability in a Coordinated Market Under Stochastic Reservation Prices

Ensuring vaccine affordability and accessibility are major challenges for the fulfillment of the immunization goals of the Global Vaccine Action Plan for the decade 2011 – 2020. Four of the five immunization goals in this plan are currently delayed because of limitations in vaccine affordability. The use of combination vaccines can help to make vaccines more accessible as long as their pricing becomes more affordable. Procurement mechanisms, such as tiered pricing and pooled procurement, have generally been used for reducing the cost of vaccine purchases, but they have not been used to ensure overall market affordability. This study extends the Antigen Bundle Pricing Problem to analyze a coordinated vaccine market and understand the effects on vaccine affordability of three factors: uncertainty regarding vaccine reservation prices, number of market segments in which customers are grouped, and the interest rate at which manufacturers recover their investment. Experimental results show that increasing the number of market segments, in which countries are grouped, positively influences vaccine affordability but reduces overall profit for manufactures. This study proposes strategies to mitigate the impact to manufacturers by determining the optimal market segmentation of target countries while considering limited access to external funding

Learning Functional Prepositions

In first language acquisition, what does it mean for a grammatical category to have been acquired, and what are the mechanisms by which children learn functional categories in general? In the context of prepositions (Ps), if the lexical/functional divide cuts through the P category, as has been suggested in the theoretical literature, then constructivist accounts of language acquisition would predict that children develop adult-like competence with the more abstract units, functional Ps, at a slower rate compared to their acquisition of lexical Ps. Nativists instead assume that the features of functional P are made available by Universal Grammar (UG), and are mapped as quickly, if not faster, than the semantic features of their lexical counterparts. Conversely, if Ps are either all lexical or all functional, on both accounts of acquisition we should observe few differences in learning. Three empirical studies of the development of P were conducted via computer analysis of the English and Spanish sub-corpora of the CHILDES database. Study 1 analyzed errors in child usage of Ps, finding almost no errors in commission in either language, but that the English learners lag in their production of functional Ps relative to lexical Ps. That no such delay was found in the Spanish data suggests that the English pattern is not universal. Studies 2 and 3 applied novel measures of phrasal (P head + nominal complement) productivity to the data. Study 2 examined prepositional phrases (PPs) whose head-complement pairs appeared in both child and adult speech, while Study 3 considered PPs produced by children that never occurred in adult speech. In both studies the productivity of Ps for English children developed faster than that of lexical Ps. In Spanish there were few differences, suggesting that children had already mastered both orders of Ps early in acquisition. These empirical results suggest that at least in English P is indeed a split category, and that children acquire the syntax of the functional subset very quickly, committing almost no errors. The UG position is thus supported. Next, the dissertation investigates a \u27soft nativist\u27 acquisition strategy that composes the distributional analysis of input, minimal a priori knowledge of the possible co-occurrence of morphosyntactic features associated with functional elements, and linguistic knowledge that is presumably acquired via the experience of pragmatic, communicative situations. The output of the analysis consists in a mapping of morphemes to the feature bundles of nominative pronouns for English and Spanish, plus specific claims about the sort of knowledge required from experience. The acquisition model is then extended to adpositions, to examine what, if anything, distributional analysis can tell us about the functional sequences of PPs. The results confirm the theoretical position according to which spatiotemporal Ps are lexical in character, rooting their own extended projections, and that functional Ps express an aspectual sequence in the functional superstructure of the PP

Learning, Arts, and the Brain: The Dana Consortium Report on Arts and Cognition

Reports findings from multiple neuroscientific studies on the impact of arts training on the enhancement of other cognitive capacities, such as reading acquisition, sequence learning, geometrical reasoning, and memory