On the merits of tetrapolar impedance spectroscopy for monitoring lithium concentration variations in human blood plasma

Bipolar disorder is characterized as a manic-depressive psychiatric syndrome with life-threatening risks to the patient. Diagnosed individuals undergo long-term lithium therapy which has proven to be effective for mood stabilization. Maintaining blood lithium concentration levels within a narrow therapeutic window between 0.6-1.5 mM is vital for the patient as slightly elevated concentrations of the order of 0.1 mM can be toxic. This paper aims to evaluate the merits of tetrapolar electrical impedance spectroscopy (TEIS) as an alternative method in monitoring blood Lithium levels. Measurements were performed using a custom-made tetrapolar probe in human blood plasma with Lithium concentrations covering the therapeutic range. The results indicate a limit of detection less than 0.1 mM and a response time of less than 5 s. Prediction of Lithium concentration levels using impedance values is in good agreement with conventional standard techniques to approximately 0.05 mM. This technique provides a basis for further development of instrumentation for point of care healthcare technologies

The development of insulated electrocardiogram electrodes

An integrated system was developed, consisting of an insulated electrode and an impedance transformer, which can be used for the acquisition of electrocardiographic data. The electrode consists of a thin layer of dielectric material deposited onto a silicon substrate. The impedance transformer is an operational amplifier used in the unity gain configuration. Both electrode and impedance transformer are contained in a plastic housing identical to that used with the NASA Apollo-type electrode. The lower cut off frequency of the electrode system is between 0.01 and 1.0 Hz, depending on the dielectric used and its thickness. Clinical quality electrocardiograms were obtained with these electrodes

Technology applications

A summary of NASA Technology Utilization programs for the period of 1 December 1971 through 31 May 1972 is presented. An abbreviated description of the overall Technology Utilization Applications Program is provided as a background for the specific applications examples. Subjects discussed are in the broad headings of: (1) cancer, (2) cardiovascular disease, (2) medical instrumentation, (4) urinary system disorders, (5) rehabilitation medicine, (6) air and water pollution, (7) housing and urban construction, (8) fire safety, (9) law enforcement and criminalistics, (10) transportation, and (11) mine safety

Advanced sensors technology survey

This project assesses the state-of-the-art in advanced or 'smart' sensors technology for NASA Life Sciences research applications with an emphasis on those sensors with potential applications on the space station freedom (SSF). The objectives are: (1) to conduct literature reviews on relevant advanced sensor technology; (2) to interview various scientists and engineers in industry, academia, and government who are knowledgeable on this topic; (3) to provide viewpoints and opinions regarding the potential applications of this technology on the SSF; and (4) to provide summary charts of relevant technologies and centers where these technologies are being developed

Modern Telemetry

Telemetry is based on knowledge of various disciplines like Electronics, Measurement, Control and Communication along with their combination. This fact leads to a need of studying and understanding of these principles before the usage of Telemetry on selected problem solving. Spending time is however many times returned in form of obtained data or knowledge which telemetry system can provide. Usage of telemetry can be found in many areas from military through biomedical to real medical applications. Modern way to create a wireless sensors remotely connected to central system with artificial intelligence provide many new, sometimes unusual ways to get a knowledge about remote objects behaviour. This book is intended to present some new up to date accesses to telemetry problems solving by use of new sensors conceptions, new wireless transfer or communication techniques, data collection or processing techniques as well as several real use case scenarios describing model examples. Most of book chapters deals with many real cases of telemetry issues which can be used as a cookbooks for your own telemetry related problems

Applications of aerospace technology in the public sector

Current activities of the program to accelerate specific applications of space related technology in major public sector problem areas are summarized for the period 1 June 1971 through 30 November 1971. An overview of NASA technology, technology applications, and supporting activities are presented. Specific technology applications in biomedicine are reported including cancer detection, treatment and research; cardiovascular diseases, diagnosis, and treatment; medical instrumentation; kidney function disorders, treatment, and research; and rehabilitation medicine

Wireless colorimetric readout to enable resource-limited point-of-care

Patientennahe Diagnostik in Entwicklungsländer birgt spezielle Herausforderungen, die ihren Erfolg bisher begrenzen. Diese Arbeit widmet sich daher der Entwicklung eines in seiner Herstellung skalierbaren und vielseitig einsetzbaren funkbasierten Auslesegerätes für Laborteststreifen. Durch die Kombination einer wachsenden Auswahl an papierbasierten Teststreifendiagnostiken mit gedruckter Elektronik und unter Berücksichtigung des diagnostischen Alltags im südlichen Afrika wurde ein Gerät entwickelt, das Teststreifen zuverlässig ausliest und die Daten per Funk an eine Datenbank übertragen kann. Die Technik basiert auf RFID-Tags (radio frequency identification devices), welche auf verschiedene flexible Substrate gedruckt wurden, um die technische Umsetzbarkeit und Funktionalität zu evaluieren. Um den Preis für die geplante Anwendung niedrig zu halten, wurden unter anderem Papier und Karton als Substrate genutzt. Das Ergebnis dieser Studie sind passive RFID-Tags auf unterschiedlichen, meist günstigen Substraten, die über eine Distanz von über 75 mm betrieben und ausgelesen werden können. Basierend auf der über RFID bereitgestellten Energie und Datenübertragung wurde eine Ausleseeinheit für Standardpapierstreifentests entwickelt und integriert. Durch das Auslesen verschiedener Teststreifen wurde das Gerät evaluiert und in seiner Aussagekraft mit einer scanner-basierten Aufnahme und anschließender Bildanalyse (ImageJ), einem kommerziellen Auslesegerät sowie einer manuellen Auslesung mit Hilfe von Farbtabellen verglichen. Das Gerät kann die Streifen zuverlässig auslesen und die Daten über die RFID-Schnittstelle übertragen. Die funkbasierte Ausleseeinheit ist mit verschiedenen kommerziellen Teststreifen sowohl im biodiagnostischen (lateral flow tests) wie auch im chemischen Bereich (pH-Wert) kompatibel. Die modulare Lösung erlaubt ein breites Einsatzgebiet und führt dadurch zu reduzierten Trainingszeiten der Anwender und einer zuverlässigen Handhabung. Die vorgestellte Lösung ist äußerst kostengünstig und bedarf keiner Wartung, wodurch sie sich sehr gut für den Einsatz in abgelegenen Feldkrankenhäusern eignet. Es wurde ein skalierbarer Prototyp entwickelt, der auf konventionellen Herstellungsverfahren der Verpackungsindustrie aufbaut. Aktuell handelt es sich noch um einen bogenbasierten Prozess, der sich aber prinzipiell auch auf Rolle-zu-Rolle Maschinen übertragen lässt. Bei der Entwicklung des Geräts spielte die Möglichkeit der lokalen Herstellung in den Einsatzländern eine große Rolle. Diese hätte neben der Generierung von Arbeitsplätzen auch den Vorteil einer einfacheren Verteilung der Geräte in ländliche Regionen, in denen sie den größten Nutzen für die Diagnostik erzielen würden

Multi-frequency segmental bio-impedance device:design, development and applications

Bio-impedance analysis (BIA) provides a rapid, non-invasive technique for body composition estimation. BIA offers a convenient alternative to standard techniques such as MRI, CT scan or DEXA scan for selected types of body composition analysis. The accuracy of BIA is limited because it is an indirect method of composition analysis. It relies on linear relationships between measured impedance and morphological parameters such as height and weight to derive estimates. To overcome these underlying limitations of BIA, a multi-frequency segmental bio-impedance device was constructed through a series of iterative enhancements and improvements of existing BIA instrumentation. Key features of the design included an easy to construct current-source and compact PCB design. The final device was trialled with 22 human volunteers and measured impedance was compared against body composition estimates obtained by DEXA scan. This enabled the development of newer techniques to make BIA predictions. To add a ‘visual aspect’ to BIA, volunteers were scanned in 3D using an inexpensive scattered light gadget (Xbox Kinect controller) and 3D volumes of their limbs were compared with BIA measurements to further improve BIA predictions. A three-stage digital filtering scheme was also implemented to enable extraction of heart-rate data from recorded bio-electrical signals. Additionally modifications have been introduced to measure change in bio-impedance with motion, this could be adapted to further improve accuracy and veracity for limb composition analysis. The findings in this thesis aim to give new direction to the prediction of body composition using BIA. The design development and refinement applied to BIA in this research programme suggest new opportunities to enhance the accuracy and clinical utility of BIA for the prediction of body composition analysis. In particular, the use of bio-impedance to predict limb volumes which would provide an additional metric for body composition measurement and help distinguish between fat and muscle content