5,610 research outputs found

    A Deep Learning-Based Fully Automated Pipeline for Regurgitant Mitral Valve Anatomy Analysis From 3D Echocardiography

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    Three-dimensional transesophageal echocardiography (3DTEE) is the recommended imaging technique for the assessment of mitral valve (MV) morphology and lesions in case of mitral regurgitation (MR) requiring surgical or transcatheter repair. Such assessment is key to thorough intervention planning and to intraprocedural guidance. However, it requires segmentation from 3DTEE images, which is timeconsuming, operator-dependent, and often merely qualitative. In the present work, a novel workflow to quantify the patient-specific MV geometry from 3DTEE is proposed. The developed approach relies on a 3D multi-decoder residual convolutional neural network (CNN) with a U-Net architecture for multi-class segmentation of MV annulus and leaflets. The CNN was trained and tested on a dataset comprising 55 3DTEE examinations of MR-affected patients. After training, the CNN is embedded into a fully automatic, and hence fully repeatable, pipeline that refines the predicted segmentation, detects MV anatomical landmarks and quantifies MV morphology. The trained 3D CNN achieves an average Dice score of 0.82 +/- 0.06, mean surface distance of 0.43 +/- 0.14 mm and 95% Hausdorff Distance (HD) of 3.57 +/- 1.56 mm before segmentation refinement, outperforming a state-of-the-art baseline residual U-Net architecture, and provides an unprecedented multi-class segmentation of the annulus, anterior and posterior leaflet. The automatic 3D linear morphological measurements of the annulus and leaflets, specifically diameters and lengths, exhibit differences of less than 1.45 mm when compared to ground truth values. These measurements also demonstrate strong overall agreement with analyses conducted by semi-automated commercial software. The whole process requires minimal user interaction and requires approximately 15 seconds

    Deep generative models for network data synthesis and monitoring

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    Measurement and monitoring are fundamental tasks in all networks, enabling the down-stream management and optimization of the network. Although networks inherently have abundant amounts of monitoring data, its access and effective measurement is another story. The challenges exist in many aspects. First, the inaccessibility of network monitoring data for external users, and it is hard to provide a high-fidelity dataset without leaking commercial sensitive information. Second, it could be very expensive to carry out effective data collection to cover a large-scale network system, considering the size of network growing, i.e., cell number of radio network and the number of flows in the Internet Service Provider (ISP) network. Third, it is difficult to ensure fidelity and efficiency simultaneously in network monitoring, as the available resources in the network element that can be applied to support the measurement function are too limited to implement sophisticated mechanisms. Finally, understanding and explaining the behavior of the network becomes challenging due to its size and complex structure. Various emerging optimization-based solutions (e.g., compressive sensing) or data-driven solutions (e.g. deep learning) have been proposed for the aforementioned challenges. However, the fidelity and efficiency of existing methods cannot yet meet the current network requirements. The contributions made in this thesis significantly advance the state of the art in the domain of network measurement and monitoring techniques. Overall, we leverage cutting-edge machine learning technology, deep generative modeling, throughout the entire thesis. First, we design and realize APPSHOT , an efficient city-scale network traffic sharing with a conditional generative model, which only requires open-source contextual data during inference (e.g., land use information and population distribution). Second, we develop an efficient drive testing system — GENDT, based on generative model, which combines graph neural networks, conditional generation, and quantified model uncertainty to enhance the efficiency of mobile drive testing. Third, we design and implement DISTILGAN, a high-fidelity, efficient, versatile, and real-time network telemetry system with latent GANs and spectral-temporal networks. Finally, we propose SPOTLIGHT , an accurate, explainable, and efficient anomaly detection system of the Open RAN (Radio Access Network) system. The lessons learned through this research are summarized, and interesting topics are discussed for future work in this domain. All proposed solutions have been evaluated with real-world datasets and applied to support different applications in real systems

    Design and Evaluation of a Hardware System for Online Signal Processing within Mobile Brain-Computer Interfaces

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    Brain-Computer Interfaces (BCIs) sind innovative Systeme, die eine direkte Kommunikation zwischen dem Gehirn und externen GerĂ€ten ermöglichen. Diese Schnittstellen haben sich zu einer transformativen Lösung nicht nur fĂŒr Menschen mit neurologischen Verletzungen entwickelt, sondern auch fĂŒr ein breiteres Spektrum von Menschen, das sowohl medizinische als auch nicht-medizinische Anwendungen umfasst. In der Vergangenheit hat die Herausforderung, dass neurologische Verletzungen nach einer anfĂ€nglichen Erholungsphase statisch bleiben, die Forscher dazu veranlasst, innovative Wege zu beschreiten. Seit den 1970er Jahren stehen BCIs an vorderster Front dieser BemĂŒhungen. Mit den Fortschritten in der Forschung haben sich die BCI-Anwendungen erweitert und zeigen ein großes Potenzial fĂŒr eine Vielzahl von Anwendungen, auch fĂŒr weniger stark eingeschrĂ€nkte (zum Beispiel im Kontext von Hörelektronik) sowie völlig gesunde Menschen (zum Beispiel in der Unterhaltungsindustrie). Die Zukunft der BCI-Forschung hĂ€ngt jedoch auch von der VerfĂŒgbarkeit zuverlĂ€ssiger BCI-Hardware ab, die den Einsatz in der realen Welt gewĂ€hrleistet. Das im Rahmen dieser Arbeit konzipierte und implementierte CereBridge-System stellt einen bedeutenden Fortschritt in der Brain-Computer-Interface-Technologie dar, da es die gesamte Hardware zur Erfassung und Verarbeitung von EEG-Signalen in ein mobiles System integriert. Die Architektur der Verarbeitungshardware basiert auf einem FPGA mit einem ARM Cortex-M3 innerhalb eines heterogenen ICs, was FlexibilitĂ€t und Effizienz bei der EEG-Signalverarbeitung gewĂ€hrleistet. Der modulare Aufbau des Systems, bestehend aus drei einzelnen Boards, gewĂ€hrleistet die Anpassbarkeit an unterschiedliche Anforderungen. Das komplette System wird an der Kopfhaut befestigt, kann autonom arbeiten, benötigt keine externe Interaktion und wiegt einschließlich der 16-Kanal-EEG-Sensoren nur ca. 56 g. Der Fokus liegt auf voller MobilitĂ€t. Das vorgeschlagene anpassbare Datenflusskonzept erleichtert die Untersuchung und nahtlose Integration von Algorithmen und erhöht die FlexibilitĂ€t des Systems. Dies wird auch durch die Möglichkeit unterstrichen, verschiedene Algorithmen auf EEG-Daten anzuwenden, um unterschiedliche Anwendungsziele zu erreichen. High-Level Synthesis (HLS) wurde verwendet, um die Algorithmen auf das FPGA zu portieren, was den Algorithmenentwicklungsprozess beschleunigt und eine schnelle Implementierung von Algorithmusvarianten ermöglicht. Evaluierungen haben gezeigt, dass das CereBridge-System in der Lage ist, die gesamte Signalverarbeitungskette zu integrieren, die fĂŒr verschiedene BCI-Anwendungen erforderlich ist. DarĂŒber hinaus kann es mit einer Batterie von mehr als 31 Stunden Dauerbetrieb betrieben werden, was es zu einer praktikablen Lösung fĂŒr mobile Langzeit-EEG-Aufzeichnungen und reale BCI-Studien macht. Im Vergleich zu bestehenden Forschungsplattformen bietet das CereBridge-System eine bisher unerreichte LeistungsfĂ€higkeit und Ausstattung fĂŒr ein mobiles BCI. Es erfĂŒllt nicht nur die relevanten Anforderungen an ein mobiles BCI-System, sondern ebnet auch den Weg fĂŒr eine schnelle Übertragung von Algorithmen aus dem Labor in reale Anwendungen. Im Wesentlichen liefert diese Arbeit einen umfassenden Entwurf fĂŒr die Entwicklung und Implementierung eines hochmodernen mobilen EEG-basierten BCI-Systems und setzt damit einen neuen Standard fĂŒr BCI-Hardware, die in der Praxis eingesetzt werden kann.Brain-Computer Interfaces (BCIs) are innovative systems that enable direct communication between the brain and external devices. These interfaces have emerged as a transformative solution not only for individuals with neurological injuries, but also for a broader range of individuals, encompassing both medical and non-medical applications. Historically, the challenge of neurological injury being static after an initial recovery phase has driven researchers to explore innovative avenues. Since the 1970s, BCIs have been at one forefront of these efforts. As research has progressed, BCI applications have expanded, showing potential in a wide range of applications, including those for less severely disabled (e.g. in the context of hearing aids) and completely healthy individuals (e.g. entertainment industry). However, the future of BCI research also depends on the availability of reliable BCI hardware to ensure real-world application. The CereBridge system designed and implemented in this work represents a significant leap forward in brain-computer interface technology by integrating all EEG signal acquisition and processing hardware into a mobile system. The processing hardware architecture is centered around an FPGA with an ARM Cortex-M3 within a heterogeneous IC, ensuring flexibility and efficiency in EEG signal processing. The modular design of the system, consisting of three individual boards, ensures adaptability to different requirements. With a focus on full mobility, the complete system is mounted on the scalp, can operate autonomously, requires no external interaction, and weighs approximately 56g, including 16 channel EEG sensors. The proposed customizable dataflow concept facilitates the exploration and seamless integration of algorithms, increasing the flexibility of the system. This is further underscored by the ability to apply different algorithms to recorded EEG data to meet different application goals. High-Level Synthesis (HLS) was used to port algorithms to the FPGA, accelerating the algorithm development process and facilitating rapid implementation of algorithm variants. Evaluations have shown that the CereBridge system is capable of integrating the complete signal processing chain required for various BCI applications. Furthermore, it can operate continuously for more than 31 hours with a 1800mAh battery, making it a viable solution for long-term mobile EEG recording and real-world BCI studies. Compared to existing research platforms, the CereBridge system offers unprecedented performance and features for a mobile BCI. It not only meets the relevant requirements for a mobile BCI system, but also paves the way for the rapid transition of algorithms from the laboratory to real-world applications. In essence, this work provides a comprehensive blueprint for the development and implementation of a state-of-the-art mobile EEG-based BCI system, setting a new benchmark in BCI hardware for real-world applicability

    Flood dynamics derived from video remote sensing

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    Flooding is by far the most pervasive natural hazard, with the human impacts of floods expected to worsen in the coming decades due to climate change. Hydraulic models are a key tool for understanding flood dynamics and play a pivotal role in unravelling the processes that occur during a flood event, including inundation flow patterns and velocities. In the realm of river basin dynamics, video remote sensing is emerging as a transformative tool that can offer insights into flow dynamics and thus, together with other remotely sensed data, has the potential to be deployed to estimate discharge. Moreover, the integration of video remote sensing data with hydraulic models offers a pivotal opportunity to enhance the predictive capacity of these models. Hydraulic models are traditionally built with accurate terrain, flow and bathymetric data and are often calibrated and validated using observed data to obtain meaningful and actionable model predictions. Data for accurately calibrating and validating hydraulic models are not always available, leaving the assessment of the predictive capabilities of some models deployed in flood risk management in question. Recent advances in remote sensing have heralded the availability of vast video datasets of high resolution. The parallel evolution of computing capabilities, coupled with advancements in artificial intelligence are enabling the processing of data at unprecedented scales and complexities, allowing us to glean meaningful insights into datasets that can be integrated with hydraulic models. The aims of the research presented in this thesis were twofold. The first aim was to evaluate and explore the potential applications of video from air- and space-borne platforms to comprehensively calibrate and validate two-dimensional hydraulic models. The second aim was to estimate river discharge using satellite video combined with high resolution topographic data. In the first of three empirical chapters, non-intrusive image velocimetry techniques were employed to estimate river surface velocities in a rural catchment. For the first time, a 2D hydraulicvmodel was fully calibrated and validated using velocities derived from Unpiloted Aerial Vehicle (UAV) image velocimetry approaches. This highlighted the value of these data in mitigating the limitations associated with traditional data sources used in parameterizing two-dimensional hydraulic models. This finding inspired the subsequent chapter where river surface velocities, derived using Large Scale Particle Image Velocimetry (LSPIV), and flood extents, derived using deep neural network-based segmentation, were extracted from satellite video and used to rigorously assess the skill of a two-dimensional hydraulic model. Harnessing the ability of deep neural networks to learn complex features and deliver accurate and contextually informed flood segmentation, the potential value of satellite video for validating two dimensional hydraulic model simulations is exhibited. In the final empirical chapter, the convergence of satellite video imagery and high-resolution topographical data bridges the gap between visual observations and quantitative measurements by enabling the direct extraction of velocities from video imagery, which is used to estimate river discharge. Overall, this thesis demonstrates the significant potential of emerging video-based remote sensing datasets and offers approaches for integrating these data into hydraulic modelling and discharge estimation practice. The incorporation of LSPIV techniques into flood modelling workflows signifies a methodological progression, especially in areas lacking robust data collection infrastructure. Satellite video remote sensing heralds a major step forward in our ability to observe river dynamics in real time, with potentially significant implications in the domain of flood modelling science

    Neuromodulatory effects on early visual signal processing

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    Understanding how the brain processes information and generates simple to complex behavior constitutes one of the core objectives in systems neuroscience. However, when studying different neural circuits, their dynamics and interactions researchers often assume fixed connectivity, overlooking a crucial factor - the effect of neuromodulators. Neuromodulators can modulate circuit activity depending on several aspects, such as different brain states or sensory contexts. Therefore, considering the modulatory effects of neuromodulators on the functionality of neural circuits is an indispensable step towards a more complete picture of the brain’s ability to process information. Generally, this issue affects all neural systems; hence this thesis tries to address this with an experimental and computational approach to resolve neuromodulatory effects on cell type-level in a well-define system, the mouse retina. In the first study, we established and applied a machine-learning-based classification algorithm to identify individual functional retinal ganglion cell types, which enabled detailed cell type-resolved analyses. We applied the classifier to newly acquired data of light-evoked retinal ganglion cell responses and successfully identified their functional types. Here, the cell type-resolved analysis revealed that a particular principle of efficient coding applies to all types in a similar way. In a second study, we focused on the issue of inter-experimental variability that can occur during the process of pooling datasets. As a result, further downstream analyses may be complicated by the subtle variations between the individual datasets. To tackle this, we proposed a theoretical framework based on an adversarial autoencoder with the objective to remove inter-experimental variability from the pooled dataset, while preserving the underlying biological signal of interest. In the last study of this thesis, we investigated the functional effects of the neuromodulator nitric oxide on the retinal output signal. To this end, we used our previously developed retinal ganglion cell type classifier to unravel type-specific effects and established a paired recording protocol to account for type-specific time-dependent effects. We found that certain retinal ganglion cell types showed adaptational type-specific changes and that nitric oxide had a distinct modulation of a particular group of retinal ganglion cells. In summary, I first present several experimental and computational methods that allow to study functional neuromodulatory effects on the retinal output signal in a cell type-resolved manner and, second, use these tools to demonstrate their feasibility to study the neuromodulator nitric oxide

    Rethinking data augmentation for adversarial robustness

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    Recent work has proposed novel data augmentation methods to improve the adversarial robustness of deep neural networks. In this paper, we re-evaluate such methods through the lens of different metrics that characterize the augmented manifold, finding contradictory evidence. Our extensive empirical analysis involving 5 data augmentation methods, all tested with an increasing probability of augmentation, shows that: (i) novel data augmentation methods proposed to improve adversarial robustness only improve it when combined with classical augmentations (like image flipping and rotation), and even worsen adversarial robustness if used in isolation; and (ii) adversarial robustness is significantly affected by the augmentation probability, conversely to what is claimed in recent work. We conclude by discussing how to rethink the development and evaluation of novel data augmentation methods for adversarial robustness. Our open-source code is available at https://github.com/eghbalz/rethink_da_for_a

    Motor Unit Magnetic Resonance Imaging (MUMRI) In Skeletal Muscle

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    \ua9 2024 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.Magnetic resonance imaging (MRI) is routinely used in the musculoskeletal system to measure skeletal muscle structure and pathology in health and disease. Recently, it has been shown that MRI also has promise for detecting the functional changes, which occur in muscles, commonly associated with a range of neuromuscular disorders. This review focuses on novel adaptations of MRI, which can detect the activity of the functional sub-units of skeletal muscle, the motor units, referred to as “motor unit MRI (MUMRI).” MUMRI utilizes pulsed gradient spin echo, pulsed gradient stimulated echo and phase contrast MRI sequences and has, so far, been used to investigate spontaneous motor unit activity (fasciculation) and used in combination with electrical nerve stimulation to study motor unit morphology and muscle twitch dynamics. Through detection of disease driven changes in motor unit activity, MUMRI shows promise as a tool to aid in both earlier diagnosis of neuromuscular disorders and to help in furthering our understanding of the underlying mechanisms, which proceed gross structural and anatomical changes within diseased muscle. Here, we summarize evidence for the use of MUMRI in neuromuscular disorders and discuss what future research is required to translate MUMRI toward clinical practice. Level of Evidence: 5. Technical Efficacy: Stage 3

    Self-supervised learning for transferable representations

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    Machine learning has undeniably achieved remarkable advances thanks to large labelled datasets and supervised learning. However, this progress is constrained by the labour-intensive annotation process. It is not feasible to generate extensive labelled datasets for every problem we aim to address. Consequently, there has been a notable shift in recent times toward approaches that solely leverage raw data. Among these, self-supervised learning has emerged as a particularly powerful approach, offering scalability to massive datasets and showcasing considerable potential for effective knowledge transfer. This thesis investigates self-supervised representation learning with a strong focus on computer vision applications. We provide a comprehensive survey of self-supervised methods across various modalities, introducing a taxonomy that categorises them into four distinct families while also highlighting practical considerations for real-world implementation. Our focus thenceforth is on the computer vision modality, where we perform a comprehensive benchmark evaluation of state-of-the-art self supervised models against many diverse downstream transfer tasks. Our findings reveal that self-supervised models often outperform supervised learning across a spectrum of tasks, albeit with correlations weakening as tasks transition beyond classification, particularly for datasets with distribution shifts. Digging deeper, we investigate the influence of data augmentation on the transferability of contrastive learners, uncovering a trade-off between spatial and appearance-based invariances that generalise to real-world transformations. This begins to explain the differing empirical performances achieved by self-supervised learners on different downstream tasks, and it showcases the advantages of specialised representations produced with tailored augmentation. Finally, we introduce a novel self-supervised pre-training algorithm for object detection, aligning pre-training with downstream architecture and objectives, leading to reduced localisation errors and improved label efficiency. In conclusion, this thesis contributes a comprehensive understanding of self-supervised representation learning and its role in enabling effective transfer across computer vision tasks

    Reliable Sensor Intelligence in Resource Constrained and Unreliable Environment

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    The objective of this research is to design a sensor intelligence that is reliable in a resource constrained, unreliable environment. There are various sources of variations and uncertainty involved in intelligent sensor system, so it is critical to build reliable sensor intelligence. Many prior works seek to design reliable sensor intelligence by developing robust and reliable task. This thesis suggests that along with improving task itself, task reliability quantification based early warning can further improve sensor intelligence. DNN based early warning generator quantifies task reliability based on spatiotemporal characteristics of input, and the early warning controls sensor parameters and avoids system failure. This thesis presents an early warning generator that predicts task failure due to sensor hardware induced input corruption and controls the sensor operation. Moreover, lightweight uncertainty estimator is presented to take account of DNN model uncertainty in task reliability quantification without prohibitive computation from stochastic DNN. Cross-layer uncertainty estimation is also discussed to consider the effect of PIM variations.Ph.D
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