On the Physical Design of Molecular Communication Receiver Based on Nanoscale Biosensors

Molecular communications (MC), where molecules are used to encode, transmit, and receive information, is a promising means of enabling the coordination of nanoscale devices. The paradigm has been extensively studied from various aspects, including channel modeling and noise analysis. Comparatively little attention has been given to the physical design of molecular receiver and transmitter, envisioning biological synthetic cells with intrinsic molecular reception and transmission capabilities as the future nanomachines. However, this assumption leads to a discrepancy between the envisaged applications requiring complex communication interfaces and protocols, and the very limited computational capacities of the envisioned biological nanomachines. In this paper, we examine the feasibility of designing a molecular receiver, in a physical domain other than synthetic biology, meeting the basic requirements of nanonetwork applications. We first review the state-of-the-art biosensing approaches to determine whether they can inspire a receiver design. We reveal that nanoscale field effect transistor based electrical biosensor technology (bioFET) is a particularly useful starting point for designing a molecular receiver. Focusing on bioFET-based molecular receivers with a conceptual approach, we provide a guideline elaborating on their operation principles, performance metrics and design parameters. We then provide a simple model for signal flow in silicon nanowire (SiNW) FET-based molecular receiver. Lastly, we discuss the practical challenges of implementing the receiver and present the future research avenues from a communication theoretical perspective

Diffusion Based Molecular Communication: Principle, Key Technologies, and Challenges

Molecular communication (MC) is a kind of communication technology based on biochemical molecules for internet of bio-nano things, in which the biochemical molecule is used as the information carrier for the interconnection of nano-devices. In this paper, the basic principle of diffusion based MC and the corresponding key technologies are comprehensively surveyed. In particular, the state-of-the-art achievements relative to the diffusion based MC are discussed and compared, including the system model, the system performance analysis with key influencing factors, the information coding and modulation techniques. Meanwhile, the multi-hop nano-network based on the diffusion MC is presented as well. Additionally, given the extensiveness of the research area, open issues and challenges are presented to spur future investigations, in which the involvement of channel model, information theory, self-organizing nano-network, and biochemical applications are put forward

Using spatial partitioning to reduce the bit error rate of diffusion-based molecular communications

This work builds on our earlier work on designing demodulators for diffusion-based molecular communications using a Markovian approach. The demodulation filters take the form of an ordinary differential equation (ODE) which computes the log-posteriori probability of observing a transmission symbol given the continuous history of receptor activities. A limitation of our earlier work is that the receiver is assumed to be a small cubic volume called a voxel. In this work, we extend the maximum a-posteriori demodulation to the case where the receiver may consist of multiple voxels and derive the ODE for log-posteriori probability calculation. This extension allows us to study receiver behaviour of different volumes and shapes. In particular, it also allows us to consider spatially partitioned receivers where the chemicals in the receiver are not allowed to mix. The key result of this paper is that spatial partitioning can be used to reduce bit-error rate in diffusion-based molecular communications.Comment: 39 pages, 20 figures, submitted for possible publication in IEE

MAC Protocols for Terahertz Communication: A Comprehensive Survey

Terahertz communication is emerging as a future technology to support Terabits per second link with highlighting features as high throughput and negligible latency. However, the unique features of the Terahertz band such as high path loss, scattering and reflection pose new challenges and results in short communication distance. The antenna directionality, in turn, is required to enhance the communication distance and to overcome the high path loss. However, these features in combine negate the use of traditional Medium access protocols. Therefore novel MAC protocol designs are required to fully exploit their potential benefits including efficient channel access, control message exchange, link establishment, mobility management, and line-of-sight blockage mitigation. An in-depth survey of Terahertz MAC protocols is presented in this paper. The paper highlights the key features of the Terahertz band which should be considered while designing an efficient Terahertz MAC protocol, and the decisions which if taken at Terahertz MAC layer can enhance the network performance. Different Terahertz applications at macro and nano scales are highlighted with design requirements for their MAC protocols. The MAC protocol design issues and considerations are highlighted. Further, the existing MAC protocols are also classified based on network topology, channel access mechanisms, and link establishment strategies as Transmitter and Receiver initiated communication. The open challenges and future research directions on Terahertz MAC protocols are also highlighted.Comment: Submitted to IEEE Communication Surveys and Tutorials Journa

SMIET: Simultaneous Molecular Information and Energy Transfer

The performance of communication systems is fundamentally limited by the loss of energy through propagation and circuit inefficiencies. In this article, we show that it is possible to achieve ultra low energy communications at the nano-scale, if diffusive molecules are used for carrying data. Whilst the energy of electromagnetic waves will inevitably decay as a function of transmission distance and time, the energy in individual molecules does not. Over time, the receiver has an opportunity to recover some, if not all of the molecular energy transmitted. The article demonstrates the potential of ultra-low energy simultaneous molecular information and energy transfer (SMIET) through the design of two different nano-relay systems, and the discusses how molecular communications can benefit more from crowd energy harvesting than traditional wave-based systems

A Novel Time-Based Modulation Scheme in Time-Asynchronous Channels for Molecular Communications

In this paper, a novel time-based modulation scheme is proposed in the time-asynchronous channel for diffusion-based molecular communication systems with drift. Based on this modulation scheme, we demonstrate that the sample variance of information molecules' arrival time approximately follows a noncentral chi-squared distribution. According to its conditional probability density function (PDF), the asynchronous receiver designs are deduced based on the maximum likelihood (ML) detection, with or without background noise in the channel environment. Since the proposed schemes can be applied to the case of transmitting multiple information molecules, simulation results reveal that the bit error ratio (BER) performance improves with the increase of the number of released information molecules. Furthermore, when the background noise is not negligible, our proposed asynchronous scheme outperforms the asynchronous modulation techniques based on encoding information on the time between two consecutive release of information molecules.Comment: 11 pages, 10 figure

A Physical Channel Model for Wired Nano-Communication Networks

In this paper, we propose a new end-to-end system for wired nano-communication networks using a self-assembled polymer. The self-assembly of a polymer creates a channel between the transmitter and the receiver in the form of a conductive nanowire that uses electrons as carriers of information. We derive the channel's analytical model and its master equation to study the dynamic process of the polymer self-assembly. We validate the analytical model with numerical and Monte-Carlo simulations. Then, we approximate the master equation by a one-dimensional Fokker-Planck equation and we solve this equation analytically and numerically. We formulate the expressions of the polymer elongation rate, its diffusion coefficient and the nullcline to study the distribution and the stability of the self-assembled nanowire. This study shows promising results for realizing stable polymer-based wired nanonetworks that can achieve high throughput

A molecular communications model for drug delivery

This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g. a tumor), able to deliver drug molecules in the diseased area. Suitably located transmitters are designed to release a continuous flow of drug molecules in the surrounding environment, where they diffuse and reach the target. These molecules are received when they chemically react with compliant receptors deployed on the receiver surface. In these conditions, if the release rate is relatively high and the drug absorption time is significant, congestion may happen, essentially at the receiver site. This phenomenon limits the drug absorption rate and makes the signal transmission ineffective, with an undesired diffusion of drug molecules elsewhere in the body. The original contribution of this paper consists of a theoretical analysis of the causes of congestion in diffusion-based molecular communications. For this purpose, it is proposed a reception model consisting of a set of pure loss queuing systems. The proposed model exhibits an excellent agreement with the results of a simulation campaign made by using the Biological and Nano-Scale communication simulator version 2 (BiNS2), a well-known simulator for molecular communications, whose reliability has been assessed through in-vitro experiments. The obtained results can be used in rate control algorithms to optimally determine the optimal release rate of molecules in drug delivery applications

A Comprehensive Survey of Recent Advancements in Molecular Communication

With much advancement in the field of nanotechnology, bioengineering and synthetic biology over the past decade, microscales and nanoscales devices are becoming a reality. Yet the problem of engineering a reliable communication system between tiny devices is still an open problem. At the same time, despite the prevalence of radio communication, there are still areas where traditional electromagnetic waves find it difficult or expensive to reach. Points of interest in industry, cities, and medical applications often lie in embedded and entrenched areas, accessible only by ventricles at scales too small for conventional radio waves and microwaves, or they are located in such a way that directional high frequency systems are ineffective. Inspired by nature, one solution to these problems is molecular communication (MC), where chemical signals are used to transfer information. Although biologists have studied MC for decades, it has only been researched for roughly 10 year from a communication engineering lens. Significant number of papers have been published to date, but owing to the need for interdisciplinary work, much of the results are preliminary. In this paper, the recent advancements in the field of MC engineering are highlighted. First, the biological, chemical, and physical processes used by an MC system are discussed. This includes different components of the MC transmitter and receiver, as well as the propagation and transport mechanisms. Then, a comprehensive survey of some of the recent works on MC through a communication engineering lens is provided. The paper ends with a technology readiness analysis of MC and future research directions.Comment: Accepted for publication in IEEE Communications Surveys & Tutorial

A Survey of Biological Building Blocks for Synthetic Molecular Communication Systems

Synthetic molecular communication (MC) is a new communication engineering paradigm which is expected to enable revolutionary applications such as smart drug delivery and real-time health monitoring. The design and implementation of synthetic MC systems (MCSs) at nano- and microscale is very challenging. This is particularly true for synthetic MCSs employing biological components as transmitters and receivers or as interfaces with natural biological MCSs. Nevertheless, since such biological components have been optimized by nature over billions of years, using them in synthetic MCSs is highly promising. This paper provides a survey of biological components that can potentially serve as the main building blocks, i.e., transmitter, receiver, and signaling particles, for the design and implementation of synthetic MCSs. Nature uses a large variety of signaling particles of different sizes and with vastly different properties for communication among biological entities. Here, we focus on three important classes of signaling particles: cations (specifically protons and calcium ions), neurotransmitters (specifically acetylcholine, dopamine, and serotonin), and phosphopeptides. For each of these candidate signaling particles, we present several specific transmitter and receiver structures mainly built upon proteins that are capable of performing the distinct physiological functionalities required from the transmitters and receivers of MCSs. Moreover, we present options for both microscale implementation of MCSs as well as the micro-to-macroscale interfaces needed for experimental evaluation of MCSs. Furthermore, we outline new research directions for the implementation and the theoretical design and analysis of the proposed transmitter and receiver architectures.Comment: 70 pages, 11 figures, 9 tables; Accepted for publication in the IEEE Communications Surveys & Tutorial