28,755 research outputs found
Linear response for spiking neuronal networks with unbounded memory
We establish a general linear response relation for spiking neuronal
networks, based on chains with unbounded memory. This relation allows us to
predict the influence of a weak amplitude time-dependent external stimuli on
spatio-temporal spike correlations, from the spontaneous statistics (without
stimulus) in a general context where the memory in spike dynamics can extend
arbitrarily far in the past. Using this approach, we show how linear response
is explicitly related to neuronal dynamics with an example, the gIF model,
introduced by M. Rudolph and A. Destexhe. This example illustrates the
collective effect of the stimuli, intrinsic neuronal dynamics, and network
connectivity on spike statistics. We illustrate our results with numerical
simulations.Comment: 60 pages, 8 figure
Quickest Sequence Phase Detection
A phase detection sequence is a length- cyclic sequence, such that the
location of any length- contiguous subsequence can be determined from a
noisy observation of that subsequence. In this paper, we derive bounds on the
minimal possible in the limit of , and describe some sequence
constructions. We further consider multiple phase detection sequences, where
the location of any length- contiguous subsequence of each sequence can be
determined simultaneously from a noisy mixture of those subsequences. We study
the optimal trade-offs between the lengths of the sequences, and describe some
sequence constructions. We compare these phase detection problems to their
natural channel coding counterparts, and show a strict separation between the
fundamental limits in the multiple sequence case. Both adversarial and
probabilistic noise models are addressed.Comment: To appear in the IEEE Transactions on Information Theor
Homeostatic competition drives tumor growth and metastasis nucleation
We propose a mechanism for tumor growth emphasizing the role of homeostatic
regulation and tissue stability. We show that competition between surface and
bulk effects leads to the existence of a critical size that must be overcome by
metastases to reach macroscopic sizes. This property can qualitatively explain
the observed size distributions of metastases, while size-independent growth
rates cannot account for clinical and experimental data. In addition, it
potentially explains the observed preferential growth of metastases on tissue
surfaces and membranes such as the pleural and peritoneal layers, suggests a
mechanism underlying the seed and soil hypothesis introduced by Stephen Paget
in 1889 and yields realistic values for metastatic inefficiency. We propose a
number of key experiments to test these concepts. The homeostatic pressure as
introduced in this work could constitute a quantitative, experimentally
accessible measure for the metastatic potential of early malignant growths.Comment: 13 pages, 11 figures, to be published in the HFSP Journa
Predictability: a way to characterize Complexity
Different aspects of the predictability problem in dynamical systems are
reviewed. The deep relation among Lyapunov exponents, Kolmogorov-Sinai entropy,
Shannon entropy and algorithmic complexity is discussed. In particular, we
emphasize how a characterization of the unpredictability of a system gives a
measure of its complexity. Adopting this point of view, we review some
developments in the characterization of the predictability of systems showing
different kind of complexity: from low-dimensional systems to high-dimensional
ones with spatio-temporal chaos and to fully developed turbulence. A special
attention is devoted to finite-time and finite-resolution effects on
predictability, which can be accounted with suitable generalization of the
standard indicators. The problems involved in systems with intrinsic randomness
is discussed, with emphasis on the important problems of distinguishing chaos
from noise and of modeling the system. The characterization of irregular
behavior in systems with discrete phase space is also considered.Comment: 142 Latex pgs. 41 included eps figures, submitted to Physics Reports.
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