Dynamic large-scale network synchronization from perception to action

Sensory-guided actions entail the processing of sensory information, generation of perceptual decisions, and the generation of appropriate actions. Neuronal activity underlying these processes is distributed into sensory, fronto-parietal, and motor brain areas, respectively. How the neuronal processing is coordinated across these brain areas to support functions from perception to action remains unknown. We investigated whether phase synchronization in large-scale networks coordinate these processes. We recorded human cortical activity with magnetoencephalography (MEG) during a task in which weak somatosensory stimuli remained unperceived or were perceived. We then assessed dynamic evolution of phase synchronization in large-scale networks from source-reconstructed MEG data by using advanced analysis approaches combined with graph theory. Here we show that perceiving and reporting of weak somatosensory stimuli is correlated with sustained strengthening of large-scale synchrony concurrently in delta/theta (3-7 Hz) and gamma (40-60 Hz) frequency bands. In a data-driven network localization, we found this synchronization to dynamically connect the task-relevant, that is, the fronto-parietal, sensory, and motor systems. The strength and temporal pattern of interareal synchronization were also correlated with the response times. These data thus show that key brain areas underlying perception, decision-making, and actions are transiently connected by large-scale dynamic phase synchronization in the delta/theta and gamma bands.Peer reviewe

The representation of respiratory movements in the inferior olive

It has been previously proposed that the inferior olive (IO) acts as a 'comparator' signalling to the cerebellum differences (errors) between signals conveying the command for movement from 'higher motor centres' and the activity these signals evoke at spinal 'centres' which also are in reciept of peripheral inputs (Oscarsson, 1973). Validation of this hypothesis has been hindered by the lack of direct access to the command signals. A review of the literature revealed that the respiratory system, as a source of centrally initiated automatic movements, offers a unique opportunity for studying both the command and outcome for a naturally occurring movement. The experiments in the first section of the thesis reinvestigate the interactions between the central respiratory drive and segmental (chest wall) reflexes. Muscle afferent activity was also monitored in intercostal nerve filaments to define proprioceptive inputs to the spinal cord and brainstem during artificial ventilation. Against this background the IO was explored by extracellular recording to seek evidence of central and peripheral-related respiratory activities. Three principal types of respiratory related activities were encountered in the dorsal accessory olive (DAO); 1), respiratory phased, mass activity; 2), respiratory phased, low frequency activity; 3), respiratory pump locked activity. The spatial location of these activities was found to correspond to a narrow, longitudinal strip in the DAO representing the segmental projection of the spino-olivary neurones located in the thoracic spinal cord, as identified anatomically by Matsushita et al. (1992). The source of these activities was investigated by cold block of the cervical spinal cord at C3. Whereas the central respiratory activity was abolished in spinal motoneurones, it persisted in the DAO indicating that the DAO receives a phasic respiratory input of supraspinal origin. Lowering the CO2 while holding the mechanical conditions in the thorax constant, resulted in changes in the olivary discharge, further indicating that the central command is fed to the olive, thus supporting the view that the olivary neurones act as a comparator signalling differences between the command for movement and the outcome

The perception of timescales in electroacoustic music

The purpose of this doctoral research is to explore the nature and perception of timescales in electroacoustic music, to examine modes of experiencing time, and to discover a method that uses this knowledge to the advantage of the composer. Although the main focus is on acousmatic works, much of the research presented here has a broader scope and is relevant to music and sound art in general. This thesis is initially inspired by Deleuze’s philosophical views on time to discover relationships between the flow of time and music, and continues to investigate time perception by exploring prevalent theories in the fields of psychology and psychoacoustics. In parallel, it identifies and systematically analyses a set of factors that influence time perception and the formation and segregation of timescales. Theoretical analysis, hypotheses and reasoning were practically tested in the five electroacoustic pieces composed for this particular research. The study revealed and reinforced the importance of psychological time in perception and interpretation of structures in music, developed the idea of using parallel temporal forms in composition, and through an exploration of timescales, it necessitated a redefinition of microsound. Moreover, an analysis of extrinsic and intrinsic factors that affect our perception of time and thus our interpretation of a musical work reinforced the notion of acousmatic music as a holistic experience that comprises all its surrounding elements at the time of listening. This research is useful for both the composer and the analyst because it offers insights into time structures, and a better understanding of the listener’s response to temporal constructs

Novel chemistry and applications of polythiazyl

Diverse investigations into the synthesis, formation, reactivity and stability of disulfur dinitride, S2N2, enabled through the fabrication of custom-made apparatus and tailored reaction conditions, are reported. The polymerisation process of the former to the (super)conductive polythiazyl material has also been explored by means of both single crystal X-ray diffraction and in situ reaction chemistry...

Implant technology and TFS processing in relation to speech discrimination and music perception and appreciation

Direct stimulation of the auditory nerve via a Cochlear Implant (CI) enables profoundly deaf subjects to perceive sounds. Many CI users find language comprehension satisfactory in quiet and accessible in the presence of noise. However, music contains different dimensions which need to be approached in different ways. Whilst both language and music take advantage of the modulation of acoustic parameters to convey information, music is an acoustically more complex stimulus than language, demanding more complex resolution mechanisms. One of the most important aspects that contributes to speech perception skills, especially when listening in a fluctuating background, is Temporal Fine Structure processing. TFS cues are pre-dominant in conveying Low Frequency (LF) signals. Harmonic (HI) and Disharmonic (DI) In-tonation are tests of pitch perception in the LF domain which are thought to depend on avail-ability of TFS cues and which are included in the protocol on this group of adult CI recipients. One of the primary aims of this thesis was the production of a new assessment tool, the Italian STARR test which was based on the measurement of speech perception using a roving-level adaptive method where the presentation level of both speech and noise signals varied between each sentence presentation. The STARR test attempts to reflect a better representation of real world listening conditions where background noise is usually present and speech intensity var-ies according to vocal capacity as well as the distance of the speaker. The outcomes for the Italian STARR in NH adults were studied to produce normative data, as well as to evaluate inter-list variability and learning effects. (Chapter 4). The second aim was to investigate LF pitch perception outcomes linked to availability of TFS cues in a group of adult CI recipients including bimodal users in relation to speech perception, in particular Italian STARR outcomes. Here it was seen that age had a significant effect on performance especially in older adults. Similarly, CI recipients (even better performers) showed abnormal findings in comparison to NH subjects. On the other hand, the significant effect of CI thresholds re-emphasized the sensitivity of the test to low intensity speech which a CI user can often encounter under everyday listening conditions. Statistically significant correlations between HI/DI and STARR performance were found. Moreover, bimodal benefit was seen both for HI/DI and STARR tests. Overall findings confirmed the usefulness of evaluating both LF pitch and speech perception in noise in order to track changes in TFS sen-sitivity for CI recipients over time and across different listening conditions which might be provided by future technological progress. (Chapter 5) Finally, the last and main aspect taken into account in this thesis was the study of the difficul-ties experienced by CI users when listening to music. An attempt was made to correlate find-ings resulting from the previous phases of this study both to Speech in Noise and to the com-plex subjective aspects of Music Perception and Appreciation: correlation analysis between HI/DI tests and the main dimensions of Speech in Noise (STARR and OLSA) and Music Ap-preciation was performed. (Chapter 6). Interestingly, positive findings were found for the two most complex types of Music (Classical, Jazz), whereas Soul did not seem to require particular competence in Pitch perception for the appreciation of the subjective variables taken into con-sideration by this study