Stochastic Synchronization of Genetic Oscillator Networks

The study of synchronization among genetic oscillators is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. Genetic networks are intrinsically noisy due to natural random intra- and inter-cellular fluctuations. Therefore, it is important to study the effects of noise perturbation on the synchronous dynamics of genetic oscillators. From the synthetic biology viewpoint, it is also important to implement biological systems that minimizing the negative influence of the perturbations. In this paper, based on systems biology approach, we provide a general theoretical result on the synchronization of genetic oscillators with stochastic perturbations. By exploiting the specific properties of many genetic oscillator models, we provide an easy-verified sufficient condition for the stochastic synchronization of coupled genetic oscillators, based on the Lur'e system approach in control theory. A design principle for minimizing the influence of noise is also presented. To demonstrate the effectiveness of our theoretical results, a population of coupled repressillators is adopted as a numerical example. In summary, we present an efficient theoretical method for analyzing the synchronization of genetic oscillator networks, which is helpful for understanding and testing the synchronization phenomena in biological organisms. Besides, the results are actually applicable to general oscillator networks.Comment: 14 pages, 4 figure

Synchronization processes in complex networks

We present an extended analysis, based on the dynamics towards synchronization of a system of coupled oscillators, of the hierarchy of communities in complex networks. In the synchronization process, different structures corresponding to well defined communities of nodes appear in a hierarchical way. The analysis also provides a useful connection between synchronization dynamics, complex networks topology and spectral graph analysis.Comment: 16 pages, 4 figures. To appear in Physica D "Special Issue on dynamics on complex networks

Synchronization of Coupled Nonidentical Genetic Oscillators

The study on the collective dynamics of synchronization among genetic oscillators is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. Genetic oscillators are biochemical networks, which can generally be modelled as nonlinear dynamic systems. We show in this paper that many genetic oscillators can be transformed into Lur'e form by exploiting the special structure of biological systems. By using control theory approach, we provide a theoretical method for analyzing the synchronization of coupled nonidentical genetic oscillators. Sufficient conditions for the synchronization as well as the estimation of the bound of the synchronization error are also obtained. To demonstrate the effectiveness of our theoretical results, a population of genetic oscillators based on the Goodwin model are adopted as numerical examples.Comment: 16 pages, 3 figure

The development of generalized synchronization on complex networks

In this paper, we investigate the development of generalized synchronization (GS) on typical complex networks, such as scale-free networks, small-world networks, random networks and modular networks. By adopting the auxiliary-system approach to networks, we show that GS can take place in oscillator networks with both heterogeneous and homogeneous degree distribution, regardless of whether the coupled chaotic oscillators are identical or nonidentical. For coupled identical oscillators on networks, we find that there exists a general bifurcation path from initial non-synchronization to final global complete synchronization (CS) via GS as the coupling strength is increased. For coupled nonidentical oscillators on networks, we further reveal how network topology competes with the local dynamics to dominate the development of GS on networks. Especially, we analyze how different coupling strategies affect the development of GS on complex networks. Our findings provide a further understanding for the occurrence and development of collective behavior in complex networks.Comment: 10 pages, 13 figure

Synchronization reveals topological scales in complex networks

We study the relationship between topological scales and dynamic time scales in complex networks. The analysis is based on the full dynamics towards synchronization of a system of coupled oscillators. In the synchronization process, modular structures corresponding to well defined communities of nodes emerge in different time scales, ordered in a hierarchical way. The analysis also provides a useful connection between synchronization dynamics, complex networks topology and spectral graph analysis.Comment: 4 pages, 3 figure

Sufficient Conditions for Fast Switching Synchronization in Time Varying Network Topologies

In previous work, empirical evidence indicated that a time-varying network could propagate sufficient information to allow synchronization of the sometimes coupled oscillators, despite an instantaneously disconnected topology. We prove here that if the network of oscillators synchronizes for the static time-average of the topology, then the network will synchronize with the time-varying topology if the time-average is achieved sufficiently fast. Fast switching, fast on the time-scale of the coupled oscillators, overcomes the descychnronizing decoherence suggested by disconnected instantaneous networks. This result agrees in spirit with that of where empirical evidence suggested that a moving averaged graph Laplacian could be used in the master-stability function analysis. A new fast switching stability criterion here-in gives sufficiency of a fast-switching network leading to synchronization. Although this sufficient condition appears to be very conservative, it provides new insights about the requirements for synchronization when the network topology is time-varying. In particular, it can be shown that networks of oscillators can synchronize even if at every point in time the frozen-time network topology is insufficiently connected to achieve synchronization.Comment: Submitted to SIAD