Weighted Point Cloud Augmentation for Neural Network Training Data Class-Imbalance

Recent developments in the field of deep learning for 3D data have demonstrated promising potential for end-to-end learning directly from point clouds. However, many real-world point clouds contain a large class im-balance due to the natural class im-balance observed in nature. For example, a 3D scan of an urban environment will consist mostly of road and facade, whereas other objects such as poles will be under-represented. In this paper we address this issue by employing a weighted augmentation to increase classes that contain fewer points. By mitigating the class im-balance present in the data we demonstrate that a standard PointNet++ deep neural network can achieve higher performance at inference on validation data. This was observed as an increase of F1 score of 19% and 25% on two test benchmark datasets; ScanNet and Semantic3D respectively where no class im-balance pre-processing had been performed. Our networks performed better on both highly-represented and under-represented classes, which indicates that the network is learning more robust and meaningful features when the loss function is not overly exposed to only a few classes.Comment: 7 pages, 6 figures, submitted for ISPRS Geospatial Week conference 201

Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits.

The cardiac transcription factor (TF) gene NKX2-5 has been associated with electrocardiographic (EKG) traits through genome-wide association studies (GWASs), but the extent to which differential binding of NKX2-5 at common regulatory variants contributes to these traits has not yet been studied. We analyzed transcriptomic and epigenomic data from induced pluripotent stem cell-derived cardiomyocytes from seven related individuals, and identified ~2,000 single-nucleotide variants associated with allele-specific effects (ASE-SNVs) on NKX2-5 binding. NKX2-5 ASE-SNVs were enriched for altered TF motifs, for heart-specific expression quantitative trait loci and for EKG GWAS signals. Using fine-mapping combined with epigenomic data from induced pluripotent stem cell-derived cardiomyocytes, we prioritized candidate causal variants for EKG traits, many of which were NKX2-5 ASE-SNVs. Experimentally characterizing two NKX2-5 ASE-SNVs (rs3807989 and rs590041) showed that they modulate the expression of target genes via differential protein binding in cardiac cells, indicating that they are functional variants underlying EKG GWAS signals. Our results show that differential NKX2-5 binding at numerous regulatory variants across the genome contributes to EKG phenotypes

Relevance of Negative Links in Graph Partitioning: A Case Study Using Votes From the European Parliament

In this paper, we want to study the informative value of negative links in signed complex networks. For this purpose, we extract and analyze a collection of signed networks representing voting sessions of the European Parliament (EP). We first process some data collected by the VoteWatch Europe Website for the whole 7 th term (2009-2014), by considering voting similarities between Members of the EP to define weighted signed links. We then apply a selection of community detection algorithms, designed to process only positive links, to these data. We also apply Parallel Iterative Local Search (Parallel ILS), an algorithm recently proposed to identify balanced partitions in signed networks. Our results show that, contrary to the conclusions of a previous study focusing on other data, the partitions detected by ignoring or considering the negative links are indeed remarkably different for these networks. The relevance of negative links for graph partitioning therefore is an open question which should be further explored.Comment: in 2nd European Network Intelligence Conference (ENIC), Sep 2015, Karlskrona, Swede