The EM Algorithm and the Rise of Computational Biology

In the past decade computational biology has grown from a cottage industry with a handful of researchers to an attractive interdisciplinary field, catching the attention and imagination of many quantitatively-minded scientists. Of interest to us is the key role played by the EM algorithm during this transformation. We survey the use of the EM algorithm in a few important computational biology problems surrounding the "central dogma"; of molecular biology: from DNA to RNA and then to proteins. Topics of this article include sequence motif discovery, protein sequence alignment, population genetics, evolutionary models and mRNA expression microarray data analysis.Comment: Published in at http://dx.doi.org/10.1214/09-STS312 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

The Translocal Event and the Polyrhythmic Diagram

This thesis identifies and analyses the key creative protocols in translocal performance practice, and ends with suggestions for new forms of transversal live and mediated performance practice, informed by theory. It argues that ontologies of emergence in dynamic systems nourish contemporary practice in the digital arts. Feedback in self-organised, recursive systems and organisms elicit change, and change transforms. The arguments trace concepts from chaos and complexity theory to virtual multiplicity, relationality, intuition and individuation (in the work of Bergson, Deleuze, Guattari, Simondon, Massumi, and other process theorists). It then examines the intersection of methodologies in philosophy, science and art and the radical contingencies implicit in the technicity of real-time, collaborative composition. Simultaneous forces or tendencies such as perception/memory, content/ expression and instinct/intellect produce composites (experience, meaning, and intuition- respectively) that affect the sensation of interplay. The translocal event is itself a diagram - an interstice between the forces of the local and the global, between the tendencies of the individual and the collective. The translocal is a point of reference for exploring the distribution of affect, parameters of control and emergent aesthetics. Translocal interplay, enabled by digital technologies and network protocols, is ontogenetic and autopoietic; diagrammatic and synaesthetic; intuitive and transductive. KeyWorx is a software application developed for realtime, distributed, multimodal media processing. As a technological tool created by artists, KeyWorx supports this intuitive type of creative experience: a real-time, translocal “jamming” that transduces the lived experience of a “biogram,” a synaesthetic hinge-dimension. The emerging aesthetics are processual – intuitive, diagrammatic and transversal

A Novel Approach for Process Mining : Intentional Process Models Discovery

International audienceSo far, process mining techniques have suggested to model processes in terms of tasks that occur during the enactment of a process. However, research on method engineering and guidance has illustrated that many issues, such as lack of flexibility or adaptation, are solved more effectively when intentions are explicitly specified. This paper presents a novel approach of process mining, called Map Miner Method (MMM). This method is designed to automate the construction of intentional process models from process logs. MMM uses Hidden Markov Models to model the relationship between users' activities logs and the strategies to fulfill their intentions. The method also includes two specific algorithms developed to infer users' intentions and construct intentional process model (Map) respectively. MMM can construct Map process models with different levels of abstraction (fine-grained and coarse-grained process models) with respect to the Map metamodel formalism (i.e., metamodel that specifies intentions and strategies of process actors). This paper presents all steps toward the construction of Map process models topology. The entire method is applied on a large-scale case study (Eclipse UDC) to mine the associated intentional process. The likelihood of the obtained process model shows a satisfying efficiency for the proposed method

Laytime and demurrage clauses in contracts of sale – how to make it work

The thesis is part of the author's master's degree in Law from the University of Berge