17,515 research outputs found
A Taxonomy of Workflow Management Systems for Grid Computing
With the advent of Grid and application technologies, scientists and
engineers are building more and more complex applications to manage and process
large data sets, and execute scientific experiments on distributed resources.
Such application scenarios require means for composing and executing complex
workflows. Therefore, many efforts have been made towards the development of
workflow management systems for Grid computing. In this paper, we propose a
taxonomy that characterizes and classifies various approaches for building and
executing workflows on Grids. We also survey several representative Grid
workflow systems developed by various projects world-wide to demonstrate the
comprehensiveness of the taxonomy. The taxonomy not only highlights the design
and engineering similarities and differences of state-of-the-art in Grid
workflow systems, but also identifies the areas that need further research.Comment: 29 pages, 15 figure
Efficient large-scale protein sequence comparison and gene matching to identify orthologs and co-orthologs
Broadly, computational approaches for ortholog assignment is a three steps process: (i) identify all putative homologs between the genomes, (ii) identify gene anchors and (iii) link anchors to identify best gene matches given their order and context. In this article, we engineer two methods to improve two important aspects of this pipeline [specifically steps (ii) and (iii)]. First, computing sequence similarity data [step (i)] is a computationally intensive task for large sequence sets, creating a bottleneck in the ortholog assignment pipeline. We have designed a fast and highly scalable sort-join method (afree) based on k-mer counts to rapidly compare all pairs of sequences in a large protein sequence set to identify putative homologs. Second, availability of complex genomes containing large gene families with prevalence of complex evolutionary events, such as duplications, has made the task of assigning orthologs and co-orthologs difficult. Here, we have developed an iterative graph matching strategy where at each iteration the best gene assignments are identified resulting in a set of orthologs and co-orthologs. We find that the afree algorithm is faster than existing methods and maintains high accuracy in identifying similar genes. The iterative graph matching strategy also showed high accuracy in identifying complex gene relationships. Standalone afree available from http://vbc.med.monash.edu.au/∼kmahmood/afree. EGM2, complete ortholog assignment pipeline (including afree and the iterative graph matching method) available from http://vbc.med.monash.edu.au/∼kmahmood/EGM2
DALiuGE: A Graph Execution Framework for Harnessing the Astronomical Data Deluge
The Data Activated Liu Graph Engine - DALiuGE - is an execution framework for
processing large astronomical datasets at a scale required by the Square
Kilometre Array Phase 1 (SKA1). It includes an interface for expressing complex
data reduction pipelines consisting of both data sets and algorithmic
components and an implementation run-time to execute such pipelines on
distributed resources. By mapping the logical view of a pipeline to its
physical realisation, DALiuGE separates the concerns of multiple stakeholders,
allowing them to collectively optimise large-scale data processing solutions in
a coherent manner. The execution in DALiuGE is data-activated, where each
individual data item autonomously triggers the processing on itself. Such
decentralisation also makes the execution framework very scalable and flexible,
supporting pipeline sizes ranging from less than ten tasks running on a laptop
to tens of millions of concurrent tasks on the second fastest supercomputer in
the world. DALiuGE has been used in production for reducing interferometry data
sets from the Karl E. Jansky Very Large Array and the Mingantu Ultrawide
Spectral Radioheliograph; and is being developed as the execution framework
prototype for the Science Data Processor (SDP) consortium of the Square
Kilometre Array (SKA) telescope. This paper presents a technical overview of
DALiuGE and discusses case studies from the CHILES and MUSER projects that use
DALiuGE to execute production pipelines. In a companion paper, we provide
in-depth analysis of DALiuGE's scalability to very large numbers of tasks on
two supercomputing facilities.Comment: 31 pages, 12 figures, currently under review by Astronomy and
Computin
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