Multi-objective optimal design of inerter-based vibration absorbers for earthquake protection of multi-storey building structures

In recent years different inerter - based vibration absorbers (IVAs) emerged for the earthquake protection of building structures coupling viscous and tuned - mass dampers with an inerter device . In the three most popular IVAs the inerter is functioning either as a motion amplifier [tuned - viscous - mass - damper (TVMD) configuration], mass amplifier [tuned - mass - damper - inerter (T MDI) configuration], or mass substitute [tuned - inerter - damper (TID) configuration]. Previous work has shown that through proper tuning , IVAs achieve enhanced earthquake - induced vibration suppression and/or weight reduction compared to conventional dampers/absorbers , but at the expense of increased control forces exerted from the IVA to the host building structure . These potentially large forces are typically not accounted for by current IVA tuning approaches. In this regard, a multi-objective IVA design approach is herein developed to identify the compromise between the competing objectives of (i) suppressing earthquake-induced vibrations in buildings, and (ii) avoiding development of excessive IVA (control) forces, while, simultaneously, assessing the appropriateness of different modeling assumptions for practical design of IVAs for earthquake engineering applications . The potential of the approach to pinpoint Pareto optimal IVA designs against the above objectives is illustrated for different IVA placements along the height of a benchmark 9-storey steel frame structure. Objective (i) is quantified according to current performanc e-based seismic design trends using first-passage reliability criteria associated with the probability of exceeding pre-specified thresholds of storey drifts and/or floor accelerations being the engineering demand parameters (EDPs) of interest . A variant, simpler, formulation is also considered using as performance quantification the sum of EDPs variances in accordance to traditional tuning methods for dynamic vibration absorbers. Objective (ii) is quantified through the variance of the IVA force. It is found that reduction of IVA control force of up to 3 times can be achieved with insignificant deterioration of building performance com pared to the extreme Pareto optimal IVA design targeting maximum vibration suppression , while TID and TMDI a chieve practically the same building performance and significantly outperform the TVMD. Moreover, it is shown that the simpler variant formulation may provide significantly suboptimal reliability performance . Lastly, it is verified that the efficacy of optimal IVA designs for stationary conditions is maintained for non-stationary stochastic excitation model capturing typical evolutionary features of earthquake excitations

Cartographic Algorithms: Problems of Implementation and Evaluation and the Impact of Digitising Errors

Cartographic generalisation remains one of the outstanding challenges in digital cartography and Geographical Information Systems (GIS). It is generally assumed that computerisation will lead to the removal of spurious variability introduced by the subjective decisions of individual cartographers. This paper demonstrates through an in‐depth study of a line simplification algorithm that computerisation introduces its own sources of variability. The algorithm, referred to as the Douglas‐Peucker algorithm in cartographic literature, has been widely used in image processing, pattern recognition and GIS for some 20 years. An analysis of this algorithm and study of some implementations in wide use identify the presence of variability resulting from the subjective decisions of software implementors. Spurious variability in software complicates the processes of evaluation and comparison of alternative algorithms for cartographic tasks. No doubt, variability in implementation could be removed by rigorous study and specification of algorithms. Such future work must address the presence of digitising error in cartographic data. Our analysis suggests that it would be difficult to adapt the Douglas‐Peucker algorithm to cope with digitising error without altering the method. Copyright © 1991, Wiley Blackwell. All rights reserve

Validating a new methodology for optical probe design and image registration in fNIRS studies

Functional near-infrared spectroscopy (fNIRS) is an imaging technique that relies on the principle of shining near-infrared light through tissue to detect changes in hemodynamic activation. An important methodological issue encountered is the creation of optimized probe geometry for fNIRS recordings. Here, across three experiments, we describe and validate a processing pipeline designed to create an optimized, yet scalable probe geometry based on selected regions of interest (ROIs) from the functional magnetic resonance imaging (fMRI) literature. In experiment 1, we created a probe geometry optimized to record changes in activation from target ROIs important for visual working memory. Positions of the sources and detectors of the probe geometry on an adult head were digitized using a motion sensor and projected onto a generic adult atlas and a segmented head obtained from the subject's MRI scan. In experiment 2, the same probe geometry was scaled down to fit a child's head and later digitized and projected onto the generic adult atlas and a segmented volume obtained from the child's MRI scan. Using visualization tools and by quantifying the amount of intersection between target ROIs and channels, we show that out of 21 ROIs, 17 and 19 ROIs intersected with fNIRS channels from the adult and child probe geometries, respectively. Further, both the adult atlas and adult subject-specific MRI approaches yielded similar results and can be used interchangeably. However, results suggest that segmented heads obtained from MRI scans be used for registering children's data. Finally, in experiment 3, we further validated our processing pipeline by creating a different probe geometry designed to record from target ROIs involved in language and motor processing

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model.

In vitro experiments are essential to understand biological mechanisms; however, the gap between monolayer tissue culture and human physiology is large, and translation of findings is often poor. Thus, there is ample opportunity for alternative experimental approaches. Here we present an approach in which human cells are isolated from human anterior cruciate ligament tissue remnants, expanded in culture, and used to form engineered ligaments. Exercise alters the biochemical milieu in the blood such that the function of many tissues, organs and bodily processes are improved. In this experiment, ligament construct culture media was supplemented with experimental human serum that has been 'conditioned' by exercise. Thus the intervention is more biologically relevant since an experimental tissue is exposed to the full endogenous biochemical milieu, including binding proteins and adjunct compounds that may be altered in tandem with the activity of an unknown agent of interest. After treatment, engineered ligaments can be analyzed for mechanical function, collagen content, morphology, and cellular biochemistry. Overall, there are four major advantages versus traditional monolayer culture and animal models, of the physiological model of ligament tissue that is presented here. First, ligament constructs are three-dimensional, allowing for mechanical properties (i.e., function) such as ultimate tensile stress, maximal tensile load, and modulus, to be quantified. Second, the enthesis, the interface between boney and sinew elements, can be examined in detail and within functional context. Third, preparing media with post-exercise serum allows for the effects of the exercise-induced biochemical milieu, which is responsible for the wide range of health benefits of exercise, to be investigated in an unbiased manner. Finally, this experimental model advances scientific research in a humane and ethical manner by replacing the use of animals, a core mandate of the National Institutes of Health, the Center for Disease Control, and the Food and Drug Administration

Uncertainty quantification in mooring cable dynamics using polynomial chaos expansions

Mooring systems exhibit high failure rates. This is especially problematic for offshore renewable energy systems, like wave and floating wind, where the mooring system can be an active component and the redundancy in the design must be kept low. Here we investigate how uncertainty in input parameters propagates through the mooring system and affects the design and dynamic response of mooring and floaters. The method used is a nonintrusive surrogate based uncertainty quantification (UQ) approach based on generalized Polynomial Chaos (gPC). We investigate the importance of the added mass, tangential drag, and normal drag coefficient of a catenary mooring cable on the peak tension in the cable. It is found that the normal drag coefficient has the greatest influence. However, the uncertainty in the coefficients plays a minor role for snap loads. Using the same methodology we analyze how deviations in anchor placement impact the dynamics of a floating axi-symmetric point-absorber. It is shown that heave and pitch are largely unaffected but surge and cable tension can be significantly altered. Our results are important towards streamlining the analysis and design of floating structures. Improving the analysis to take into account uncertainties is especially relevant for offshore renewable energy systems where the mooring system is a considerable portion of the investment

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells.

Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that is down regulated in human seminoma. Depletion of Gravin correlates with an increased mitotic index and disorganization of seminiferous tubules. Biochemical, super-resolution imaging, and enzymology approaches establish that this Gravin scaffold accumulates at the mother spindle pole during metaphase. Manipulating elements of the Gravin-Aurora A-Plk1 axis prompts mitotic delay and prevents appropriate assembly of astral microtubules to promote spindle misorientation. These pathological responses are conserved in seminiferous tubules from Gravin(-/-) mice where an overabundance of Oct3/4 positive germ line stem cells displays randomized orientation of mitotic spindles. Thus, we propose that Gravin-mediated recruitment of Aurora A and Plk1 to the mother (oldest) spindle pole contributes to the fidelity of symmetric cell division

Safety and short term outcomes of a new truly minimally-invasive mesh-less and dissection-less anchoring system for pelvic organ prolapse apical repair

Objective To evaluate the safety and short term outcomes of a new, truly minimally-invasive, mesh-less and dissection-less anchoring system for pelvic floor apical repair. Methods A prospective study was conducted using the NeuGuide™ device system for pelvic floor apical repair. The primary effectiveness outcome was centro-apical pelvic floor prolapse by POP-Q after six months. The primary safety outcome was intra-operative, immediate (first 48 h) post-operative complications and adverse effects after six months. A standardized questionnaire (UDI-6) to assess quality of life at entry and during follow-up visits was used. Patients’ six months-follow-up and evaluation are reported. Results The mean age of the study population (n=10) was 63.8±12.0 years. All patients had a previous prolapse surgery. Five had a previous hysterectomy and two had stress urinary incontinence symptoms. During surgery six patients had a concurrent colporrhaphy. There was no injury to the bladder, rectum, pudendal nerves, or major pelvic vessels and no febrile morbidity was recorded. At six months, no cases of centro-apical recurrence were noted. Patients were satisfied with the procedure and had favorable quality of life scores. Using the UDI-6 questionnaire an improvement, in all domains was seen. Moreover, although the sample size was small, the improvement in urge and overflow incontinence related domains were demonstrated to be statistically significant. Conclusions This new NeuGuide™ device allows rapid and safe introduction of a suspending suture through the sacrospinous ligament and makes sacrospinous ligament fixation easy to perform, while avoiding dissection and mesh complications