3,621 research outputs found
Decomposition of sequential and concurrent models
Le macchine a stati finiti (FSM), sistemi di transizioni (TS) e le reti di Petri (PN) sono importanti modelli formali per la progettazione di sistemi. Un problema fodamentale è la conversione da un modello all'altro. Questa tesi esplora il mondo delle reti di Petri e della decomposizione di sistemi di transizioni. Per quanto riguarda la decomposizione dei sistemi di transizioni, la teoria delle regioni rappresenta la colonna portante dell'intero processo di decomposizione, mirato soprattutto a decomposizioni che utilizzano due sottoclassi delle reti di Petri: macchine a stati e reti di Petri a scelta libera. Nella tesi si dimostra che una proprietà chiamata ``chiusura rispetto all'eccitazione" (excitation-closure) è sufficiente per produrre un insieme di reti di Petri la cui sincronizzazione è bisimile al sistema di transizioni (o rete di Petri di partenza, se la decomposizione parte da una rete di Petri), dimostrando costruttivamente l'esistenza di una bisimulazione. Inoltre, è stato implementato un software che esegue la decomposizione dei sistemi di transizioni, per rafforzare i risultati teorici con dati sperimentali sistematici. Nella seconda parte della dissertazione si analizza un nuovo modello chiamato MSFSM, che rappresenta un insieme di FSM sincronizzate da due primitive specifiche (Wait State - Stato d'Attesa e Transition Barrier - Barriera di Transizione). Tale modello trova un utilizzo significativo nella sintesi di circuiti sincroni a partire da reti di Petri a scelta libera. In particolare vengono identificati degli errori nell'approccio originale, fornendo delle correzioni.Finite State Machines (FSMs), transition systems (TSs) and Petri nets (PNs) are important models of computation ubiquitous in formal methods for modeling systems. Important problems involve the transition from one model to another. This thesis explores Petri nets, transition systems and Finite State Machines decomposition and optimization. The first part addresses decomposition of transition systems and Petri nets, based on the theory of regions, representing them by means of restricted PNs, e.g., State Machines (SMs) and Free-choice Petri nets (FCPNs). We show that the property called ``excitation-closure" is sufficient to produce a set of synchronized Petri nets bisimilar to the original transition system or to the initial Petri net (if the decomposition starts from a PN), proving by construction the existence of a bisimulation. Furthermore, we implemented a software performing the decomposition of transition systems, and reported extensive experiments. The second part of the dissertation discusses Multiple Synchronized Finite State Machines (MSFSMs) specifying a set of FSMs synchronized by specific primitives: Wait State and Transition Barrier. It introduces a method for converting Petri nets into synchronous circuits using MSFSM, identifies errors in the initial approach, and provides corrections
Dataflow Programming and Acceleration of Computationally-Intensive Algorithms
The volume of unstructured textual information continues to grow due to recent technological advancements. This resulted in an exponential growth of information generated in various formats, including blogs, posts, social networking, and enterprise documents. Numerous Enterprise Architecture (EA) documents are also created daily, such as reports, contracts, agreements, frameworks, architecture requirements, designs, and operational guides. The processing and computation of this massive amount of unstructured information necessitate substantial computing capabilities and the implementation of new techniques. It is critical to manage this unstructured information through a centralized knowledge management platform. Knowledge management is the process of managing information within an organization. This involves creating, collecting, organizing, and storing information in a way that makes it easily accessible and usable. The research involved the development textual knowledge management system, and two use cases were considered for extracting textual knowledge from documents. The first case study focused on the safety-critical documents of a railway enterprise. Safety is of paramount importance in the railway industry. There are several EA documents including manuals, operational procedures, and technical guidelines that contain critical information. Digitalization of these documents is essential for analysing vast amounts of textual knowledge that exist in these documents to improve the safety and security of railway operations. A case study was conducted between the University of Huddersfield and the Railway Safety Standard Board (RSSB) to analyse EA safety documents using Natural language processing (NLP). A graphical user interface was developed that includes various document processing features such as semantic search, document mapping, text summarization, and visualization of key trends. For the second case study, open-source data was utilized, and textual knowledge was extracted. Several features were also developed, including kernel distribution, analysis offkey trends, and sentiment analysis of words (such as unique, positive, and negative) within the documents. Additionally, a heterogeneous framework was designed using CPU/GPU and FPGAs to analyse the computational performance of document mapping
A clinical decision support system for detecting and mitigating potentially inappropriate medications
Background: Medication errors are a leading cause of preventable harm to patients. In older adults, the impact of ageing on the therapeutic effectiveness and safety of drugs is a significant concern, especially for those over 65. Consequently, certain medications called Potentially Inappropriate Medications (PIMs) can be dangerous in the elderly and should be avoided. Tackling PIMs by health professionals and patients can be time-consuming and error-prone, as the criteria underlying the definition of PIMs are complex and subject to frequent updates. Moreover, the criteria are not available in a representation that health systems can interpret and reason with directly.
Objectives: This thesis aims to demonstrate the feasibility of using an ontology/rule-based approach in a clinical knowledge base to identify potentially inappropriate medication(PIM). In addition, how constraint solvers can be used effectively to suggest alternative medications and administration schedules to solve or minimise PIM undesirable side effects.
Methodology: To address these objectives, we propose a novel integrated approach using formal rules to represent the PIMs criteria and inference engines to perform the reasoning presented in the context of a Clinical Decision Support System (CDSS). The approach aims to detect, solve, or minimise undesirable side-effects of PIMs through an ontology (knowledge base) and inference engines incorporating multiple reasoning approaches.
Contributions: The main contribution lies in the framework to formalise PIMs, including the steps required to define guideline requisites to create inference rules to detect and propose alternative drugs to inappropriate medications. No formalisation of the selected guideline (Beers Criteria) can be found in the literature, and hence, this thesis provides a novel ontology for it. Moreover, our process of minimising undesirable side effects offers a novel approach that enhances and optimises the drug rescheduling process, providing a more accurate way to minimise the effect of drug interactions in clinical practice
STPA for learning-enabled systems : a survey and a new practice
Systems Theoretic Process Analysis (STPA) is a systematic approach for hazard analysis that has been used across many industrial sectors including transportation, energy, and defense. The unstoppable trend of using Machine Learning (ML) in safety-critical systems has led to the pressing need of extending STPA to Learning-Enabled Systems (LESs). Al- though works have been carried out on various example LESs, without a systematic review, it is unclear how effective and generalisable the extended STPA methods are, and whether further improvements can be made. To this end, we present a systematic survey of 31 papers, summarising them from five perspectives (attributes of concern, objects under study, modifications, derivatives and processes being modelled). Furthermore, we identify room for improvement and accordingly introduce DeepSTPA, which enhances STPA from two aspects that are missing from the state-of-the-practice: (i) Control loop structures are explicitly extended to identify hazards from the data-driven development process spanning the ML lifecycle; (ii) Fine-grained functionalities are modelled at the layer-wise levels of ML models to detect root causes. We demonstrate and compare DeepSTPA and STPA through a case study on an autonomous emergency braking system
2023 SDSU Data Science Symposium Presentation Abstracts
This document contains abstracts for presentations and posters 2023 SDSU Data Science Symposium
2023-2024 Catalog
The 2023-2024 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:Degree RequirementsCourse OfferingsUndergraduate and Graduate Rules and Regulation
Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells
The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and activity. The presence of TF in PDAC and its role in cell proliferation, angiogenesis, and metastasis suggests that TF may be a marker of the inflammatory microenvironment driving precursor lesions of pancreatic cancer. This study examined the in vitro influence of TF on pancreatic epithelial cells and its clinical value in detecting malignant transformation within pancreatic cyst fluid (PCyF). PCyF from 27 patients with pancreatic cystic lesions was analysed in a blinded fashion. TF and fVIIa levels were measured (ELISA), and the fVIIa:TF ratios were calculated. A cut-off value for TF concentration was determined and compared to the conventional assessment parameters (radiological features, CEA and amylase). Patients were categorised into four groups based on cytopathology and two groups based on indication for resection (‘resective’). Significant histological stage-dependent increases in TF levels were observed. Mean TF concentration was significantly higher (p=0.006) in the resective (high-grade dysplasia & malignant; 1.17 ng/ml, 95% CI 0.68, 1.67) vs non-resective group (benign & low-grade dysplasia; 0.27 ng/ml, 95% CI 0.1, 0.44), with a strong positive correlation (r= 0.746, p <0.001, TF cut-off 0.75 ng/ml, AUC 0.877, p=0.002). The fVIIa:TF ratio did not add further value. Incubation of pancreatic cells with recombinant TF resulted in increased expression of a marker of epithelial to mesenchymal transition (Vimentin). This influence was moderated by supplementation with fVIIa in benign (hTERT-HPNE) but not overtly malignant pancreatic cells (AsPC-1). Cyst-associated TF levels appear to correlate with cytological progression to the malignant phenotype and may allow better discrimination (specificity 94%) of the ‘resective’ lesion, reduce healthcare costs and offer a more nuanced tool for monitoring indeterminate cystic lesions
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