Session 12: \u3cem\u3eActive Learning to Minimize the Possible Risk from Future Epidemics\u3c/em\u3e

In medical imaging informatics, for any future epidemics (e.g., Covid-19), deep learning (DL) models are of no use as they require a large dataset as they take months and even years to collect enough data (with annotations). In such a context, active learning (or human/expert-in-the-loop) is the must, where a machine can learn from the first day with minimum possible labeled data. In unsupervised learning, we propose to build pre-trained DL models that iteratively learn independently over time, where human/expert intervenes only when it makes mistakes and for only a limited data. In our work, deep features are used to classify data into two clusters (0/1: Covid-19/non-Covid-19) on two different image datasets: chest x-ray (CXR) and Computed Tomography (CT) scan of sizes 4,714 and 10,000 CTs, respectively. Using pre-trained DL models and unsupervised learning, in our active learning framework, we received the highest AUC of 0.99 and 0.94 on CXR and CT scan datasets, respectively. Not to be confused, our primary objective is to provide a strong assertion on how active learning could potentially be used to predict disease from any upcoming epidemics

Deep Learning vs Spectral Clustering into an active clustering with pairwise constraints propagation

International audienceIn our data driven world, categorization is of major importance to help end-users and decision makers understanding information structures. Supervised learning techniques rely on annotated samples that are often difficult to obtain and training often overfits. On the other hand, unsupervised clustering techniques study the structure of the data without disposing of any training data. Given the difficulty of the task, supervised learning often outperforms unsupervised learning. A compromise is to use a partial knowledge, selected in a smart way, in order to boost performance while minimizing learning costs, what is called semi-supervised learning. In such use case, Spectral Clustering proved to be an efficient method. Also, Deep Learning outperformed several state of the art classification approaches and it is interesting to test it in our context. In this paper, we firstly introduce the concept of Deep Learning into an active semi-supervised clustering process and compare it with Spectral Clustering. Secondly, we introduce constraint propagation and demonstrate how it maximizes partitioning quality while reducing annotation costs. Experimental validation is conducted on two different real datasets. Results show the potential of the clustering methods

Medical image registration using unsupervised deep neural network: A scoping literature review

In medicine, image registration is vital in image-guided interventions and other clinical applications. However, it is a difficult subject to be addressed which by the advent of machine learning, there have been considerable progress in algorithmic performance has recently been achieved for medical image registration in this area. The implementation of deep neural networks provides an opportunity for some medical applications such as conducting image registration in less time with high accuracy, playing a key role in countering tumors during the operation. The current study presents a comprehensive scoping review on the state-of-the-art literature of medical image registration studies based on unsupervised deep neural networks is conducted, encompassing all the related studies published in this field to this date. Here, we have tried to summarize the latest developments and applications of unsupervised deep learning-based registration methods in the medical field. Fundamental and main concepts, techniques, statistical analysis from different viewpoints, novelties, and future directions are elaborately discussed and conveyed in the current comprehensive scoping review. Besides, this review hopes to help those active readers, who are riveted by this field, achieve deep insight into this exciting field

Deep Learning via Stacked Sparse Autoencoders for Automated Voxel-Wise Brain Parcellation Based on Functional Connectivity

Functional brain parcellation – the delineation of brain regions based on functional connectivity – is an active research area lacking an ideal subject-specific solution independent of anatomical composition, manual feature engineering, or heavily labelled examples. Deep learning is a cutting-edge area of machine learning on the forefront of current artificial intelligence developments. Specifically, autoencoders are artificial neural networks which can be stacked to form hierarchical sparse deep models from which high-level features are compressed, organized, and extracted, without labelled training data, allowing for unsupervised learning. This thesis presents a novel application of stacked sparse autoencoders to the problem of parcellating the brain based on its components’ (voxels’) functional connectivity, focusing on the medial parietal cortex. Various depths of autoencoders are investigated, yielding results of up to (68 ± 3)% accuracy compared with ground truth parcellations using Dice’s coefficient. This data-driven functional parcellation technique offers promising growth to both the neuroimaging and machine learning communities