247 research outputs found

    Comprehensive Review on Analytical Profile of Antidepressant Drug

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    Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Venlafaxine affects chemicals in the brain that may be unbalanced in people with depression. It is used to treat major depressive disorder, anxiety and panic disorder. The present review assesses the various approaches for analysis of Venlafaxine in bulk drug as well as various formulations. A concise review represents the compilation and discussion of about more than 35 analytical methods which includes HPLC, HPTLC, UPLC, LC-MS and UV-Spectrophotometry methods implemented for investigation of Venlafaxine in biological matrices, bulk samples and in different dosage formulations. This detailed review will be of great help to the researcher who is working on Venlafaxine. Keywords: Venlafaxine; Analytical Profile; HPLC; HPTLC; Bioanalytical; Stability indicatin

    COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG

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    Desvenlafaxine  succinate (pristiq) is an important non-hormonal drug used in the treatment of major depressive disorder and problems associated with menopause.This article summarizes the synthesis and investigation of new polymorphic form of Desmethylvenlafaxine. The new polymorph has been compared with the old polymorph using XRD, DSC, FTIR, SEM and HPLC techniques. Three prominent reflections with higher intensities lying at 20.3, 13.1 and 15.8 have been noted in the XRD measurements for the new polymorph. Higher intensity (XRD) peaks for the new polymorph indicates good crystalline quality. FTIR spectra shows close match between the polymorphs. DSC measurements show enhanced thermal stability for the new polymorph. Higher purity is indicated by the HPLC studies.Key words: desvenlafaxine, polymorphism, structure, crystalline, purit
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