812 research outputs found
Identification of weakly coupled multiphysics problems. Application to the inverse problem of electrocardiography
This work addresses the inverse problem of electrocardiography from a new
perspective, by combining electrical and mechanical measurements. Our strategy
relies on the defini-tion of a model of the electromechanical contraction which
is registered on ECG data but also on measured mechanical displacements of the
heart tissue typically extracted from medical images. In this respect, we
establish in this work the convergence of a sequential estimator which combines
for such coupled problems various state of the art sequential data assimilation
methods in a unified consistent and efficient framework. Indeed we ag-gregate a
Luenberger observer for the mechanical state and a Reduced Order Unscented
Kalman Filter applied on the parameters to be identified and a POD projection
of the electrical state. Then using synthetic data we show the benefits of our
approach for the estimation of the electrical state of the ventricles along the
heart beat compared with more classical strategies which only consider an
electrophysiological model with ECG measurements. Our numerical results
actually show that the mechanical measurements improve the identifiability of
the electrical problem allowing to reconstruct the electrical state of the
coupled system more precisely. Therefore, this work is intended to be a first
proof of concept, with theoretical justifications and numerical investigations,
of the ad-vantage of using available multi-modal observations for the
estimation and identification of an electromechanical model of the heart
Efficient time splitting schemes for the monodomain equation in cardiac electrophysiology
Approximating the fast dynamics of depolarization waves in the human heart described by the monodomain model is numerically challenging. Splitting methods for the PDE-ODE coupling enable the computation with very fine space and time discretizations. Here, we compare different splitting approaches regarding convergence, accuracy and efficiency. Simulations were performed for a benchmark configuration with the Beeler–Reuter cell model on a truncated ellipsoid approximating the left ventricle including a localized stimulation. For this benchmark configuration, we provide a reference solution for the transmembrane potential. We found a semi-implicit approach with state variable interpolation to be the most efficient scheme. The results are transferred to a more physiological setup using a bi-ventricular domain with a complex external stimulation pattern to evaluate the accuracy of the activation time for different resolutions in space and time
Simulation of action potential propagation based on the ghost structure method
In this paper, a ghost structure (GS) method is proposed to simulate the monodomain model in irregular computational domains using finite difference without regenerating body-fitted grids. In order to verify the validity of the GS method, it is first used to solve the Fitzhugh-Nagumo monodomain model in rectangular and circular regions at different states (the stationary and moving states). Then, the GS method is used to simulate the propagation of the action potential (AP) in transverse and longitudinal sections of a healthy human heart, and with left bundle branch block (LBBB). Finally, we analyze the AP and calcium concentration under healthy and LBBB conditions. Our numerical results show that the GS method can accurately simulate AP propagation with different computational domains either stationary or moving, and we also find that LBBB will cause the left ventricle to contract later than the right ventricle, which in turn affects synchronized contraction of the two ventricles
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