Non-thermal membrane effects of electromagnetic fields and therapeutic applications in oncology

The temperature-independent effects of electromagnetic fields (EMF) have been controversial for decades. Here, we critically analyze the available literature on non-thermal effects of radiofrequency (RF) and microwave EMF. We present a literature review of preclinical and clinical data on non-thermal antiproliferative effects of various EMF applications, including conventional RF hyperthermia (HT, cRF-HT). Further, we suggest and evaluate plausible biophysical and electrophysiological models to decipher non-thermal antiproliferative membrane effects. Available preclinical and clinical data provide sufficient evidence for the existence of non-thermal antiproliferative effects of exposure to cRF-HT, and in particular, amplitude modulated (AM)-RF-HT. In our model, transmembrane ion channels function like RF rectifiers and low-pass filters. cRF-HT induces ion fluxes and AM-RF-HT additionally promotes membrane vibrations at specific resonance frequencies, which explains the non-thermal antiproliferative membrane effects via ion disequilibrium (especially of Ca(2+)) and/or resonances causing membrane depolarization, the opening of certain (especially Ca(2+)) channels, or even hole formation. AM-RF-HT may be tumor-specific owing to cancer-specific ion channels and because, with increasing malignancy, membrane elasticity parameters may differ from that in normal tissues. Published literature suggests that non-thermal antiproliferative effects of cRF-HT are likely to exist and could present a high potential to improve future treatments in oncology

Annual Report 2013 / Institute for Pulsed Power and Microwave Technology = Jahresbericht 2013 / Institut für Hochleistungsimpuls- und Mikrowellentechnik. (KIT Scientific Reports ; 7666)

The Institute for Pulsed Power and Microwave Technology (Institut für Hochleistungsimpuls- und Mikrowellentechnik - IHM) is doing research in the areas of pulsed power and high power microwave technologies. Both, research and development of high power sources as well as related applications are in the focus. Applications for pulsed power technologies are ranging from material processing to bioelectrics. Microwave technologies are focusing on RF sources for electron cyclotron resonance heating and on applications for material processing at microwave frequencies

Annual Report 2010 / Institute for Pulsed Power and Microwave Technology = Jahresbericht 2010 / Institut für Hochleistungsimpuls- und Mikrowellentechnik. (KIT Scientific Reports ; 7590)

Arbeitsgebiete des IHM sind die Forschung, Entwicklung, Ausbildung und, in Zusammenarbeit mit dem KIT-Innovationsmanagement (IMA) sowie industriellen Partnern, der Technologietransfer im Bereich der Impuls- und Mikrowellentechnik bei hohen Leistungen zur Anwendung dieser Verfahren bei der Energiegewinnung durch kontrollierte Kernfusion, der Transmutation von Kernbrennstoffen, der Material-Prozesstechnik und der nicht-nuklearen Energietechnik. Dieser Jahresbericht zeigt die F&E-Arbeiten in 2010

Electrodynamics of Correlated Electron Materials

We review studies of the electromagnetic response of various classes of correlated electron materials including transition metal oxides, organic and molecular conductors, intermetallic compounds with $d$- and $f$-electrons as well as magnetic semiconductors. Optical inquiry into correlations in all these diverse systems is enabled by experimental access to the fundamental characteristics of an ensemble of electrons including their self-energy and kinetic energy. Steady-state spectroscopy carried out over a broad range of frequencies from microwaves to UV light and fast optics time-resolved techniques provide complimentary prospectives on correlations. Because the theoretical understanding of strong correlations is still evolving, the review is focused on the analysis of the universal trends that are emerging out of a large body of experimental data augmented where possible with insights from numerical studies.Comment: 78 pages, 55 figures, 984 reference

ICR ANNUAL REPORT 2019 (Volume 26)[All Pages]

This Annual Report covers from 1 January to 31 December 201

Laboratory directed research and development. FY 1995 progress report

This document presents an overview of Laboratory Directed Research and Development Programs at Los Alamos. The nine technical disciplines in which research is described include materials, engineering and base technologies, plasma, fluids, and particle beams, chemistry, mathematics and computational science, atmic and molecular physics, geoscience, space science, and astrophysics, nuclear and particle physics, and biosciences. Brief descriptions are provided in the above programs