A Comparative Study for 2D and 3D Computer-aided Diagnosis Methods for Solitary Pulmonary Nodules

Many computer-aided diagnosis (CAD) methods, including 2D and 3D approaches, have been proposed for solitary pulmonary nodules (SPNs). However, the detection and diagnosis of SPNs remain challenging in many clinical circumstances. One goal of this work is to investigate the relative diagnostic accuracy of 2D and 3D methods. An additional goal is to develop a two-stage approach that combines the simplicity of 2D and the accuracy of 3D methods. The experimental results show statistically significant differences between the diagnostic accuracy of 2D and 3D methods. The results also show that with a very minor drop in diagnostic performance the two-stage approach can significantly reduce the number of nodules needed to be processed by the 3D method, streamlining the computational demand

Distortion Robust Biometric Recognition

abstract: Information forensics and security have come a long way in just a few years thanks to the recent advances in biometric recognition. The main challenge remains a proper design of a biometric modality that can be resilient to unconstrained conditions, such as quality distortions. This work presents a solution to face and ear recognition under unconstrained visual variations, with a main focus on recognition in the presence of blur, occlusion and additive noise distortions. First, the dissertation addresses the problem of scene variations in the presence of blur, occlusion and additive noise distortions resulting from capture, processing and transmission. Despite their excellent performance, ’deep’ methods are susceptible to visual distortions, which significantly reduce their performance. Sparse representations, on the other hand, have shown huge potential capabilities in handling problems, such as occlusion and corruption. In this work, an augmented SRC (ASRC) framework is presented to improve the performance of the Spare Representation Classifier (SRC) in the presence of blur, additive noise and block occlusion, while preserving its robustness to scene dependent variations. Different feature types are considered in the performance evaluation including image raw pixels, HoG and deep learning VGG-Face. The proposed ASRC framework is shown to outperform the conventional SRC in terms of recognition accuracy, in addition to other existing sparse-based methods and blur invariant methods at medium to high levels of distortion, when particularly used with discriminative features. In order to assess the quality of features in improving both the sparsity of the representation and the classification accuracy, a feature sparse coding and classification index (FSCCI) is proposed and used for feature ranking and selection within both the SRC and ASRC frameworks. The second part of the dissertation presents a method for unconstrained ear recognition using deep learning features. The unconstrained ear recognition is performed using transfer learning with deep neural networks (DNNs) as a feature extractor followed by a shallow classifier. Data augmentation is used to improve the recognition performance by augmenting the training dataset with image transformations. The recognition performance of the feature extraction models is compared with an ensemble of fine-tuned networks. The results show that, in the case where long training time is not desirable or a large amount of data is not available, the features from pre-trained DNNs can be used with a shallow classifier to give a comparable recognition accuracy to the fine-tuned networks.Dissertation/ThesisDoctoral Dissertation Electrical Engineering 201

Improved α\alpha-GAN architecture for generating 3D connected volumes with an application to radiosurgery treatment planning

Generative Adversarial Networks (GANs) have gained significant attention in several computer vision tasks for generating high-quality synthetic data. Various medical applications including diagnostic imaging and radiation therapy can benefit greatly from synthetic data generation due to data scarcity in the domain. However, medical image data is typically kept in 3D space, and generative models suffer from the curse of dimensionality issues in generating such synthetic data. In this paper, we investigate the potential of GANs for generating connected 3D volumes. We propose an improved version of 3D $\alpha$-GAN by incorporating various architectural enhancements. On a synthetic dataset of connected 3D spheres and ellipsoids, our model can generate fully connected 3D shapes with similar geometrical characteristics to that of training data. We also show that our 3D GAN model can successfully generate high-quality 3D tumor volumes and associated treatment specifications (e.g., isocenter locations). Similar moment invariants to the training data as well as fully connected 3D shapes confirm that improved 3D $\alpha$-GAN implicitly learns the training data distribution, and generates realistic-looking samples. The capability of improved 3D $\alpha$-GAN makes it a valuable source for generating synthetic medical image data that can help future research in this domain