461,095 research outputs found

    UV detector monitors organic contamination of optical surfaces

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    Silicon carbide, insensitive to visible light, is used in photodetectors. System contamination can be monitored during the normal operation without interference to the operator, and without shielding from ambient light

    Contamination Estimation via Convex Relaxations

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    Identifying anomalies and contamination in datasets is important in a wide variety of settings. In this paper, we describe a new technique for estimating contamination in large, discrete valued datasets. Our approach considers the normal condition of the data to be specified by a model consisting of a set of distributions. Our key contribution is in our approach to contamination estimation. Specifically, we develop a technique that identifies the minimum number of data points that must be discarded (i.e., the level of contamination) from an empirical data set in order to match the model to within a specified goodness-of-fit, controlled by a p-value. Appealing to results from large deviations theory, we show a lower bound on the level of contamination is obtained by solving a series of convex programs. Theoretical results guarantee the bound converges at a rate of O(log(p)/p)O(\sqrt{\log(p)/p}), where p is the size of the empirical data set.Comment: To appear, ISIT 201

    Genomic aberrations in normal tissue adjacent to HER2-amplified breast cancers: field cancerization or contaminating tumor cells?

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    Field cancerization effects as well as isolated tumor cell foci extending well beyond the invasive tumor margin have been described previously to account for local recurrence rates following breast conserving surgery despite adequate surgical margins and breast radiotherapy. To look for evidence of possible tumor cell contamination or field cancerization by genetic effects, a pilot study (Study 1: 12 sample pairs) followed by a verification study (Study 2: 20 sample pairs) were performed on DNA extracted from HER2-positive breast tumors and matching normal adjacent mammary tissue samples excised 1-3 cm beyond the invasive tumor margin. High-resolution molecular inversion probe (MIP) arrays were used to compare genomic copy number variations, including increased HER2 gene copies, between the paired samples; as well, a detailed histologic and immunohistochemical (IHC) re-evaluation of all Study 2 samples was performed blinded to the genomic results to characterize the adjacent normal tissue composition bracketing the DNA-extracted samples. Overall, 14/32 (44 %) sample pairs from both studies produced genome-wide evidence of genetic aberrations including HER2 copy number gains within the adjacent normal tissue samples. The observed single-parental origin of monoallelic HER2 amplicon haplotypes shared by informative tumor-normal pairs, as well as commonly gained loci elsewhere on 17q, suggested the presence of contaminating tumor cells in the genomically aberrant normal samples. Histologic and IHC analyses identified occult 25-200 μm tumor cell clusters overexpressing HER2 scattered in more than half, but not all, of the genomically aberrant normal samples re-evaluated, but in none of the genomically normal samples. These genomic and microscopic findings support the conclusion that tumor cell contamination rather than genetic field cancerization represents the likeliest cause of local clinical recurrence rates following breast conserving surgery, and mandate caution in assuming the genomic normalcy of histologically benign appearing peritumor breast tissue

    Payload/orbiter contamination control requirement study: Preliminary contamination mission support plan

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    Progress is reported on the mission support plan and those support activities envisioned to be applicable and necessary during premission and postmission phases of the Spacelab program. The purpose, role, and requirements of the contamination control operations for the first two missions of the Spacelab equipped Space Transportation System are discussed. The organization of the contamination control operation and its relationship to and interfaces with other mission support functions is also discussed. Some specific areas of contamination to be investigated are treated. They are: (1) windows and viewports, (2) experiment equipment, (3) thermal control surfaces, (4) the contaminant induced atmosphere (as differentiated from the normal ambient atmosphere at the orbit altitude), and (5) optical navigation instruments

    Effects of carbon/graphite fiber contamination on high voltage electrical insulation

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    The contamination mechanics and resulting failure modes of high voltage electrical insulation due to carbon/graphite fibers were examined. The high voltage insulation vulnerability to carbon/graphite fiber induced failure was evaluated using a contamination system which consisted of a fiber chopper, dispersal chamber, a contamination chamber, and air ducts and suction blower. Tests were conducted to evaluate the effects of fiber length, weathering, and wetness on the insulator's resistance to carbon/graphite fibers. The ability of nuclear, fossil, and hydro power generating stations to maintain normal power generation when the surrounding environment is contaminated by an accidental carbon fiber release was investigated. The vulnerability assessment included only the power plant generating equipment and its associated controls, instrumentation, and auxiliary and support systems

    Risk assessment of failure of outdoor high voltage polluted insulators under combined stresses near shoreline

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    The aim of this paper is to investigate the various effects of climate conditions on outdoor insulators in coastal areas as a result of saline contamination under acidic and normal cold fog, determining significant electrical and physico-chemical changes on the insulator surface and considering the effect of discharge current, electric field distribution and surface roughness. To replicate similar conditions near the shoreline, experimental investigations have been carried out on insulation materials with the combined application of saline contamination and acidic or normal cold fog. The test samples included silicone rubber (SiR), ethylene propylene diene monomer (EPDM) and high-density polyethylene (HDPE), which were used as reference. The materials are of the same composition as those used in real-life outdoor high voltage insulators. All samples were aged separately in an environmental chamber for 150 h for various saline contaminations combined with acidic and normal cold fog, and were generated by means of the adopted experimental setup. This analysis represented conditions similar to those existing near the shoreline exposed to saline and acid spray during winter and early spring. Electric field and discharge current along polymeric samples were examined under acidic and normal cold fog. Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopic (SEM) were used to probe the physico-chemical changes on the samples surface and investigate the hydrophobicity recovery property after aging tests. Finally, a comparative study was carried out on polymeric samples before and after being exposed to the acidic and normal cold fog based on the results obtained from the experiment. Research data may provide references for the better prediction of surface degradation as well as for the better material coating and design of external insulation

    Systematic Bias in Genomic Classification Due to Contaminating Non-neoplastic Tissue in Breast Tumor Samples

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    Abstract Background Genomic tests are available to predict breast cancer recurrence and to guide clinical decision making. These predictors provide recurrence risk scores along with a measure of uncertainty, usually a confidence interval. The confidence interval conveys random error and not systematic bias. Standard tumor sampling methods make this problematic, as it is common to have a substantial proportion (typically 30-50%) of a tumor sample comprised of histologically benign tissue. This "normal" tissue could represent a source of non-random error or systematic bias in genomic classification. Methods To assess the performance characteristics of genomic classification to systematic error from normal contamination, we collected 55 tumor samples and paired tumor-adjacent normal tissue. Using genomic signatures from the tumor and paired normal, we evaluated how increasing normal contamination altered recurrence risk scores for various genomic predictors. Results Simulations of normal tissue contamination caused misclassification of tumors in all predictors evaluated, but different breast cancer predictors showed different types of vulnerability to normal tissue bias. While two predictors had unpredictable direction of bias (either higher or lower risk of relapse resulted from normal contamination), one signature showed predictable direction of normal tissue effects. Due to this predictable direction of effect, this signature (the PAM50) was adjusted for normal tissue contamination and these corrections improved sensitivity and negative predictive value. For all three assays quality control standards and/or appropriate bias adjustment strategies can be used to improve assay reliability. Conclusions Normal tissue sampled concurrently with tumor is an important source of bias in breast genomic predictors. All genomic predictors show some sensitivity to normal tissue contamination and ideal strategies for mitigating this bias vary depending upon the particular genes and computational methods used in the predictor

    On the distribution of an effective channel estimator for multi-cell massive MIMO

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    Accurate channel estimation is of utmost importance for massive MIMO systems to provide significant improvements in spectral and energy efficiency. In this work, we present a study on the distribution of a simple but yet effective and practical channel estimator for multi-cell massive MIMO systems suffering from pilot-contamination. The proposed channel estimator performs well under moderate to aggressive pilot contamination scenarios without previous knowledge of the inter-cell large-scale channel coefficients and noise power, asymptotically approximating the performance of the linear MMSE estimator as the number of antennas increases. We prove that the distribution of the proposed channel estimator can be accurately approximated by the circularly-symmetric complex normal distribution, when the number of antennas, M, deployed at the base station is greater than 10
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