An Optoelectronic Stimulator for Retinal Prosthesis

Retinal prostheses require the presence of viable population of cells in the inner retina. Evaluations of retina with Age-Related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP) have shown a large number of cells remain in the inner retina compared with the outer retina. Therefore, vision loss caused by AMD and RP is potentially treatable with retinal prostheses. Photostimulation based retinal prostheses have shown many advantages compared with retinal implants. In contrary to electrode based stimulation, light does not require mechanical contact. Therefore, the system can be completely external and not does have the power and degradation problems of implanted devices. In addition, the stimulating point is flexible and does not require a prior decision on the stimulation location. Furthermore, a beam of light can be projected on tissue with both temporal and spatial precision. This thesis aims at fi nding a feasible solution to such a system. Firstly, a prototype of an optoelectronic stimulator was proposed and implemented by using the Xilinx Virtex-4 FPGA evaluation board. The platform was used to demonstrate the possibility of photostimulation of the photosensitized neurons. Meanwhile, with the aim of developing a portable retinal prosthesis, a system on chip (SoC) architecture was proposed and a wide tuning range sinusoidal voltage-controlled oscillator (VCO) which is the pivotal component of the system was designed. The VCO is based on a new designed Complementary Metal Oxide Semiconductor (CMOS) Operational Transconductance Ampli er (OTA) which achieves a good linearity over a wide tuning range. Both the OTA and the VCO were fabricated in the AMS 0.35 µm CMOS process. Finally a 9X9 CMOS image sensor with spiking pixels was designed. Each pixel acts as an independent oscillator whose frequency is controlled by the incident light intensity. The sensor was fabricated in the AMS 0.35 µm CMOS Opto Process. Experimental validation and measured results are provided

Deep Learning in Cardiology

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Deep learning is a representation learning method that consists of layers that transform the data non-linearly, thus, revealing hierarchical relationships and structures. In this review we survey deep learning application papers that use structured data, signal and imaging modalities from cardiology. We discuss the advantages and limitations of applying deep learning in cardiology that also apply in medicine in general, while proposing certain directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table

VLSI analogs of neuronal visual processing: a synthesis of form and function

This thesis describes the development and testing of a simple visual system fabricated using complementary metal-oxide-semiconductor (CMOS) very large scale integration (VLSI) technology. This visual system is composed of three subsystems. A silicon retina, fabricated on a single chip, transduces light and performs signal processing in a manner similar to a simple vertebrate retina. A stereocorrespondence chip uses bilateral retinal input to estimate the location of objects in depth. A silicon optic nerve allows communication between chips by a method that preserves the idiom of action potential transmission in the nervous system. Each of these subsystems illuminates various aspects of the relationship between VLSI analogs and their neurobiological counterparts. The overall synthetic visual system demonstrates that analog VLSI can capture a significant portion of the function of neural structures at a systems level, and concomitantly, that incorporating neural architectures leads to new engineering approaches to computation in VLSI. The relationship between neural systems and VLSI is rooted in the shared limitations imposed by computing in similar physical media. The systems discussed in this text support the belief that the physical limitations imposed by the computational medium significantly affect the evolving algorithm. Since circuits are essentially physical structures, I advocate the use of analog VLSI as powerful medium of abstraction, suitable for understanding and expressing the function of real neural systems. The working chip elevates the circuit description to a kind of synthetic formalism. The behaving physical circuit provides a formal test of theories of function that can be expressed in the language of circuits

Training Spiking Neural Networks Using Lessons From Deep Learning

The brain is the perfect place to look for inspiration to develop more efficient neural networks. The inner workings of our synapses and neurons provide a glimpse at what the future of deep learning might look like. This paper serves as a tutorial and perspective showing how to apply the lessons learnt from several decades of research in deep learning, gradient descent, backpropagation and neuroscience to biologically plausible spiking neural neural networks. We also explore the delicate interplay between encoding data as spikes and the learning process; the challenges and solutions of applying gradient-based learning to spiking neural networks; the subtle link between temporal backpropagation and spike timing dependent plasticity, and how deep learning might move towards biologically plausible online learning. Some ideas are well accepted and commonly used amongst the neuromorphic engineering community, while others are presented or justified for the first time here. A series of companion interactive tutorials complementary to this paper using our Python package, snnTorch, are also made available: https://snntorch.readthedocs.io/en/latest/tutorials/index.htm

Interfacing of neuromorphic vision, auditory and olfactory sensors with digital neuromorphic circuits

The conventional Von Neumann architecture imposes strict constraints on the development of intelligent adaptive systems. The requirements of substantial computing power to process and analyse complex data make such an approach impractical to be used in implementing smart systems. Neuromorphic engineering has produced promising results in applications such as electronic sensing, networking architectures and complex data processing. This interdisciplinary field takes inspiration from neurobiological architecture and emulates these characteristics using analogue Very Large Scale Integration (VLSI). The unconventional approach of exploiting the non-linear current characteristics of transistors has aided in the development of low-power adaptive systems that can be implemented in intelligent systems. The neuromorphic approach is widely applied in electronic sensing, particularly in vision, auditory, tactile and olfactory sensors. While conventional sensors generate a huge amount of redundant output data, neuromorphic sensors implement the biological concept of spike-based output to generate sparse output data that corresponds to a certain sensing event. The operation principle applied in these sensors supports reduced power consumption with operating efficiency comparable to conventional sensors. Although neuromorphic sensors such as Dynamic Vision Sensor (DVS), Dynamic and Active pixel Vision Sensor (DAVIS) and AEREAR2 are steadily expanding their scope of application in real-world systems, the lack of spike-based data processing algorithms and complex interfacing methods restricts its applications in low-cost standalone autonomous systems. This research addresses the issue of interfacing between neuromorphic sensors and digital neuromorphic circuits. Current interfacing methods of these sensors are dependent on computers for output data processing. This approach restricts the portability of these sensors, limits their application in a standalone system and increases the overall cost of such systems. The proposed methodology simplifies the interfacing of these sensors with digital neuromorphic processors by utilizing AER communication protocols and neuromorphic hardware developed under the Convolution AER Vision Architecture for Real-time (CAVIAR) project. The proposed interface is simulated using a JAVA model that emulates a typical spikebased output of a neuromorphic sensor, in this case an olfactory sensor, and functions that process this data based on supervised learning. The successful implementation of this simulation suggests that the methodology is a practical solution and can be implemented in hardware. The JAVA simulation is compared to a similar model developed in Nengo, a standard large-scale neural simulation tool. The successful completion of this research contributes towards expanding the scope of application of neuromorphic sensors in standalone intelligent systems. The easy interfacing method proposed in this thesis promotes the portability of these sensors by eliminating the dependency on computers for output data processing. The inclusion of neuromorphic Field Programmable Gate Array (FPGA) board allows reconfiguration and deployment of learning algorithms to implement adaptable systems. These low-power systems can be widely applied in biosecurity and environmental monitoring. With this thesis, we suggest directions for future research in neuromorphic standalone systems based on neuromorphic olfaction

Chemical Bionics - a novel design approach using ion sensitive field effect transistors

In the late 1980s Carver Mead introduced Neuromorphic engineering in which various aspects of the neural systems of the body were modelled using VLSI1 circuits. As a result most bio-inspired systems to date concentrate on modelling the electrical behaviour of neural systems such as the eyes, ears and brain. The reality is however that biological systems rely on chemical as well as electrical principles in order to function. This thesis introduces chemical bionics in which the chemically-dependent physiology of specific cells in the body is implemented for the development of novel bio-inspired therapeutic devices. The glucose dependent pancreatic beta cell is shown to be one such cell, that is designed and fabricated to form the first silicon metabolic cell. By replicating the bursting behaviour of biological beta cells, which respond to changes in blood glucose, a bio-inspired prosthetic for glucose homeostasis of Type I diabetes is demonstrated. To compliment this, research to further develop the Ion Sensitive Field Effect Transistor (ISFET) on unmodified CMOS is also presented for use as a monolithic sensor for chemical bionic systems. Problems arising by using the native passivation of CMOS as a sensing surface are described and methods of compensation are presented. A model for the operation of the device in weak inversion is also proposed for exploitation of its physical primitives to make novel monolithic solutions. Functional implementations in various technologies is also detailed to allow future implementations chemical bionic circuits. Finally the ISFET integrate and fire neuron, which is the first of its kind, is presented to be used as a chemical based building block for many existing neuromorphic circuits. As an example of this a chemical imager is described for spatio-temporal monitoring of chemical species and an acid base discriminator for monitoring changes in concentration around a fixed threshold is also proposed

Center for Space Microelectronics Technology 1988-1989 technical report

The 1988 to 1989 Technical Report of the JPL Center for Space Microelectronics Technology summarizes the technical accomplishments, publications, presentations, and patents of the center. Listed are 321 publications, 282 presentations, and 140 new technology reports and patents