Microarray image processing: A novel neural network framework

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Due to the vast success of bioengineering techniques, a series of large-scale analysis tools has been developed to discover the functional organization of cells. Among them, cDNA microarray has emerged as a powerful technology that enables biologists to cDNA microarray technology has enabled biologists to study thousands of genes simultaneously within an entire organism, and thus obtain a better understanding of the gene interaction and regulation mechanisms involved. Although microarray technology has been developed so as to offer high tolerances, there exists high signal irregularity through the surface of the microarray image. The imperfection in the microarray image generation process causes noises of many types, which contaminate the resulting image. These errors and noises will propagate down through, and can significantly affect, all subsequent processing and analysis. Therefore, to realize the potential of such technology it is crucial to obtain high quality image data that would indeed reflect the underlying biology in the samples. One of the key steps in extracting information from a microarray image is segmentation: identifying which pixels within an image represent which gene. This area of spotted microarray image analysis has received relatively little attention relative to the advances in proceeding analysis stages. But, the lack of advanced image analysis, including the segmentation, results in sub-optimal data being used in all downstream analysis methods. Although there is recently much research on microarray image analysis with many methods have been proposed, some methods produce better results than others. In general, the most effective approaches require considerable run time (processing) power to process an entire image. Furthermore, there has been little progress on developing sufficiently fast yet efficient and effective algorithms the segmentation of the microarray image by using a highly sophisticated framework such as Cellular Neural Networks (CNNs). It is, therefore, the aim of this thesis to investigate and develop novel methods processing microarray images. The goal is to produce results that outperform the currently available approaches in terms of PSNR, k-means and ICC measurements.Aleppo University, Syri

Microarray image processing : a novel neural network framework

Due to the vast success of bioengineering techniques, a series of large-scale analysis tools has been developed to discover the functional organization of cells. Among them, cDNA microarray has emerged as a powerful technology that enables biologists to cDNA microarray technology has enabled biologists to study thousands of genes simultaneously within an entire organism, and thus obtain a better understanding of the gene interaction and regulation mechanisms involved. Although microarray technology has been developed so as to offer high tolerances, there exists high signal irregularity through the surface of the microarray image. The imperfection in the microarray image generation process causes noises of many types, which contaminate the resulting image. These errors and noises will propagate down through, and can significantly affect, all subsequent processing and analysis. Therefore, to realize the potential of such technology it is crucial to obtain high quality image data that would indeed reflect the underlying biology in the samples. One of the key steps in extracting information from a microarray image is segmentation: identifying which pixels within an image represent which gene. This area of spotted microarray image analysis has received relatively little attention relative to the advances in proceeding analysis stages. But, the lack of advanced image analysis, including the segmentation, results in sub-optimal data being used in all downstream analysis methods. Although there is recently much research on microarray image analysis with many methods have been proposed, some methods produce better results than others. In general, the most effective approaches require considerable run time (processing) power to process an entire image. Furthermore, there has been little progress on developing sufficiently fast yet efficient and effective algorithms the segmentation of the microarray image by using a highly sophisticated framework such as Cellular Neural Networks (CNNs). It is, therefore, the aim of this thesis to investigate and develop novel methods processing microarray images. The goal is to produce results that outperform the currently available approaches in terms of PSNR, k-means and ICC measurements.EThOS - Electronic Theses Online ServiceAleppo University, SyriaGBUnited Kingdo

Analisis orientado a objetos de imágenes de teledetección para cartografia forestal : bases conceptuales y un metodo de segmentacion para obtener una particion inicial para la clasificacion = Object-oriented analysis of remote sensing images for land cover mapping : Conceptual foundations and a segmentation method to derive a baseline partition for classification

El enfoque comúnmente usado para analizar las imágenes de satélite con fines cartográficos da lugar a resultados insatisfactorios debido principalmente a que únicamente utiliza los patrones espectrales de los píxeles, ignorando casi por completo la estructura espacial de la imagen. Además, la equiparación de las clases de cubierta a tipos de materiales homogéneos permite que cualquier parte arbitrariamente delimitada dentro de una tesela del mapa siga siendo un referente del concepto definido por su etiqueta. Esta posibilidad es incongruente con el modelo jerárquico del paisaje cada vez más aceptado en Ecología del Paisaje, que asume que la homogeneidad depende de la escala de observación y en cualquier caso es más semántica que biofísica, y que por tanto los paisajes son intrínsecamente heterogéneos y están compuestos de unidades (patches) que funcionan simultáneamente como un todo diferente de lo que les rodea y como partes de un todo mayor. Por tanto se hace necesario un nuevo enfoque (orientado a objetos) que sea compatible con este modelo y en el que las unidades básicas del análisis sean delimitadas de acuerdo a la variación espacial del fenómeno estudiado. Esta tesis pretende contribuir a este cambio de paradigma en teledetección, y sus objetivos concretos son: 1.- Poner de relieve las deficiencias del enfoque tradicionalmente empleado en la clasificación de imágenes de satélite. 2.- Sentar las bases conceptuales de un enfoque alternativo basado en zonas básicas clasificables como objetos. 3.- Desarrollar e implementar una versión demostrativa de un método automático que convierte una imagen multiespectral en una capa vectorial formada por esas zonas. La estrategia que se propone es producir, basándose en la estructura espacial de las imágenes, una partición de estas en la que cada región puede considerarse relativamente homogénea y diferente de sus vecinas y que además supera (aunque no por mucho) el tamaño de la unidad mínima cartografiable. Cada región se asume corresponde a un rodal que tras la clasificación será agregado junto a otros rodales vecinos en una región mayor que en conjunto pueda verse como una instancia de un cierto tipo de objetos que más tarde son representados en el mapa mediante teselas de una clase particular

Remote Sensing of Earth Resources: A literature survey with indexes (1970 - 1973 supplement). Section 1: Abstracts

Abstracts of reports, articles, and other documents introduced into the NASA scientific and technical information system between March 1970 and December 1973 are presented in the following areas: agriculture and forestry, environmental changes and cultural resources, geodesy and cartography, geology and mineral resources, oceanography and marine resources, hydrology and water management, data processing and distribution systems, instrumentation and sensors, and economic analysis

Graduate Course Descriptions, 2005 Fall

Wright State University graduate course descriptions from Fall 2005

Graduate Course Descriptions, 2006 Winter

Wright State University graduate course descriptions from Winter 2006

1996 Laboratory directed research and development annual report

This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1996. In addition to a programmatic and financial overview, the report includes progress reports from 259 individual R&D projects in seventeen categories. The general areas of research include: engineered processes and materials; computational and information sciences; microelectronics and photonics; engineering sciences; pulsed power; advanced manufacturing technologies; biomedical engineering; energy and environmental science and technology; advanced information technologies; counterproliferation; advanced transportation; national security technology; electronics technologies; idea exploration and exploitation; production; and science at the interfaces - engineering with atoms

Summary of Research 1994

The views expressed in this report are those of the authors and do not reflect the official policy or position of the Department of Defense or the U.S. Government.This report contains 359 summaries of research projects which were carried out under funding of the Naval Postgraduate School Research Program. A list of recent publications is also included which consists of conference presentations and publications, books, contributions to books, published journal papers, and technical reports. The research was conducted in the areas of Aeronautics and Astronautics, Computer Science, Electrical and Computer Engineering, Mathematics, Mechanical Engineering, Meteorology, National Security Affairs, Oceanography, Operations Research, Physics, and Systems Management. This also includes research by the Command, Control and Communications (C3) Academic Group, Electronic Warfare Academic Group, Space Systems Academic Group, and the Undersea Warfare Academic Group