Sensor fusion in distributed cortical circuits

The substantial motion of the nature is to balance, to survive, and to reach perfection. The evolution in biological systems is a key signature of this quintessence. Survival cannot be achieved without understanding the surrounding world. How can a fruit fly live without searching for food, and thereby with no form of perception that guides the behavior? The nervous system of fruit fly with hundred thousand of neurons can perform very complicated tasks that are beyond the power of an advanced supercomputer. Recently developed computing machines are made by billions of transistors and they are remarkably fast in precise calculations. But these machines are unable to perform a single task that an insect is able to do by means of thousands of neurons. The complexity of information processing and data compression in a single biological neuron and neural circuits are not comparable with that of developed today in transistors and integrated circuits. On the other hand, the style of information processing in neural systems is also very different from that of employed by microprocessors which is mostly centralized. Almost all cognitive functions are generated by a combined effort of multiple brain areas. In mammals, Cortical regions are organized hierarchically, and they are reciprocally interconnected, exchanging the information from multiple senses. This hierarchy in circuit level, also preserves the sensory world within different levels of complexity and within the scope of multiple modalities. The main behavioral advantage of that is to understand the real-world through multiple sensory systems, and thereby to provide a robust and coherent form of perception. When the quality of a sensory signal drops, the brain can alternatively employ other information pathways to handle cognitive tasks, or even to calibrate the error-prone sensory node. Mammalian brain also takes a good advantage of multimodal processing in learning and development; where one sensory system helps another sensory modality to develop. Multisensory integration is considered as one of the main factors that generates consciousness in human. Although, we still do not know where exactly the information is consolidated into a single percept, and what is the underpinning neural mechanism of this process? One straightforward hypothesis suggests that the uni-sensory signals are pooled in a ploy-sensory convergence zone, which creates a unified form of perception. But it is hard to believe that there is just one single dedicated region that realizes this functionality. Using a set of realistic neuro-computational principles, I have explored theoretically how multisensory integration can be performed within a distributed hierarchical circuit. I argued that the interaction of cortical populations can be interpreted as a specific form of relation satisfaction in which the information preserved in one neural ensemble must agree with incoming signals from connected populations according to a relation function. This relation function can be seen as a coherency function which is implicitly learnt through synaptic strength. Apart from the fact that the real world is composed of multisensory attributes, the sensory signals are subject to uncertainty. This requires a cortical mechanism to incorporate the statistical parameters of the sensory world in neural circuits and to deal with the issue of inaccuracy in perception. I argued in this thesis how the intrinsic stochasticity of neural activity enables a systematic mechanism to encode probabilistic quantities within neural circuits, e.g. reliability, prior probability. The systematic benefit of neural stochasticity is well paraphrased by the problem of Duns Scotus paradox: imagine a donkey with a deterministic brain that is exposed to two identical food rewards. This may make the animal suffer and die starving because of indecision. In this thesis, I have introduced an optimal encoding framework that can describe the probability function of a Gaussian-like random variable in a pool of Poisson neurons. Thereafter a distributed neural model is proposed that can optimally combine conditional probabilities over sensory signals, in order to compute Bayesian Multisensory Causal Inference. This process is known as a complex multisensory function in the cortex. Recently it is found that this process is performed within a distributed hierarchy in sensory cortex. Our work is amongst the first successful attempts that put a mechanistic spotlight on understanding the underlying neural mechanism of Multisensory Causal Perception in the brain, and in general the theory of decentralized multisensory integration in sensory cortex. Engineering information processing concepts in the brain and developing new computing technologies have been recently growing. Neuromorphic Engineering is a new branch that undertakes this mission. In a dedicated part of this thesis, I have proposed a Neuromorphic algorithm for event-based stereoscopic fusion. This algorithm is anchored in the idea of cooperative computing that dictates the defined epipolar and temporal constraints of the stereoscopic setup, to the neural dynamics. The performance of this algorithm is tested using a pair of silicon retinas

Mathematical Modeling of Biological Systems

Mathematical modeling is a powerful approach supporting the investigation of open problems in natural sciences, in particular physics, biology and medicine. Applied mathematics allows to translate the available information about real-world phenomena into mathematical objects and concepts. Mathematical models are useful descriptive tools that allow to gather the salient aspects of complex biological systems along with their fundamental governing laws, by elucidating the system behavior in time and space, also evidencing symmetry, or symmetry breaking, in geometry and morphology. Additionally, mathematical models are useful predictive tools able to reliably forecast the future system evolution or its response to specific inputs. More importantly, concerning biomedical systems, such models can even become prescriptive tools, allowing effective, sometimes optimal, intervention strategies for the treatment and control of pathological states to be planned. The application of mathematical physics, nonlinear analysis, systems and control theory to the study of biological and medical systems results in the formulation of new challenging problems for the scientific community. This Special Issue includes innovative contributions of experienced researchers in the field of mathematical modelling applied to biology and medicine

Sensor fusion in distributed cortical circuits

The substantial motion of the nature is to balance, to survive, and to reach perfection. The evolution in biological systems is a key signature of this quintessence. Survival cannot be achieved without understanding the surrounding world. How can a fruit fly live without searching for food, and thereby with no form of perception that guides the behavior? The nervous system of fruit fly with hundred thousand of neurons can perform very complicated tasks that are beyond the power of an advanced supercomputer. Recently developed computing machines are made by billions of transistors and they are remarkably fast in precise calculations. But these machines are unable to perform a single task that an insect is able to do by means of thousands of neurons. The complexity of information processing and data compression in a single biological neuron and neural circuits are not comparable with that of developed today in transistors and integrated circuits. On the other hand, the style of information processing in neural systems is also very different from that of employed by microprocessors which is mostly centralized. Almost all cognitive functions are generated by a combined effort of multiple brain areas. In mammals, Cortical regions are organized hierarchically, and they are reciprocally interconnected, exchanging the information from multiple senses. This hierarchy in circuit level, also preserves the sensory world within different levels of complexity and within the scope of multiple modalities. The main behavioral advantage of that is to understand the real-world through multiple sensory systems, and thereby to provide a robust and coherent form of perception. When the quality of a sensory signal drops, the brain can alternatively employ other information pathways to handle cognitive tasks, or even to calibrate the error-prone sensory node. Mammalian brain also takes a good advantage of multimodal processing in learning and development; where one sensory system helps another sensory modality to develop. Multisensory integration is considered as one of the main factors that generates consciousness in human. Although, we still do not know where exactly the information is consolidated into a single percept, and what is the underpinning neural mechanism of this process? One straightforward hypothesis suggests that the uni-sensory signals are pooled in a ploy-sensory convergence zone, which creates a unified form of perception. But it is hard to believe that there is just one single dedicated region that realizes this functionality. Using a set of realistic neuro-computational principles, I have explored theoretically how multisensory integration can be performed within a distributed hierarchical circuit. I argued that the interaction of cortical populations can be interpreted as a specific form of relation satisfaction in which the information preserved in one neural ensemble must agree with incoming signals from connected populations according to a relation function. This relation function can be seen as a coherency function which is implicitly learnt through synaptic strength. Apart from the fact that the real world is composed of multisensory attributes, the sensory signals are subject to uncertainty. This requires a cortical mechanism to incorporate the statistical parameters of the sensory world in neural circuits and to deal with the issue of inaccuracy in perception. I argued in this thesis how the intrinsic stochasticity of neural activity enables a systematic mechanism to encode probabilistic quantities within neural circuits, e.g. reliability, prior probability. The systematic benefit of neural stochasticity is well paraphrased by the problem of Duns Scotus paradox: imagine a donkey with a deterministic brain that is exposed to two identical food rewards. This may make the animal suffer and die starving because of indecision. In this thesis, I have introduced an optimal encoding framework that can describe the probability function of a Gaussian-like random variable in a pool of Poisson neurons. Thereafter a distributed neural model is proposed that can optimally combine conditional probabilities over sensory signals, in order to compute Bayesian Multisensory Causal Inference. This process is known as a complex multisensory function in the cortex. Recently it is found that this process is performed within a distributed hierarchy in sensory cortex. Our work is amongst the first successful attempts that put a mechanistic spotlight on understanding the underlying neural mechanism of Multisensory Causal Perception in the brain, and in general the theory of decentralized multisensory integration in sensory cortex. Engineering information processing concepts in the brain and developing new computing technologies have been recently growing. Neuromorphic Engineering is a new branch that undertakes this mission. In a dedicated part of this thesis, I have proposed a Neuromorphic algorithm for event-based stereoscopic fusion. This algorithm is anchored in the idea of cooperative computing that dictates the defined epipolar and temporal constraints of the stereoscopic setup, to the neural dynamics. The performance of this algorithm is tested using a pair of silicon retinas

Internet Traffic Engineering : An Artificial Intelligence Approach

Dissertação de Mestrado em Ciência de Computadores, apresentada à Faculdade de Ciências da Universidade do Port

Complexity Science in Human Change

This reprint encompasses fourteen contributions that offer avenues towards a better understanding of complex systems in human behavior. The phenomena studied here are generally pattern formation processes that originate in social interaction and psychotherapy. Several accounts are also given of the coordination in body movements and in physiological, neuronal and linguistic processes. A common denominator of such pattern formation is that complexity and entropy of the respective systems become reduced spontaneously, which is the hallmark of self-organization. The various methodological approaches of how to model such processes are presented in some detail. Results from the various methods are systematically compared and discussed. Among these approaches are algorithms for the quantification of synchrony by cross-correlational statistics, surrogate control procedures, recurrence mapping and network models.This volume offers an informative and sophisticated resource for scholars of human change, and as well for students at advanced levels, from graduate to post-doctoral. The reprint is multidisciplinary in nature, binding together the fields of medicine, psychology, physics, and neuroscience

Using MapReduce Streaming for Distributed Life Simulation on the Cloud

Distributed software simulations are indispensable in the study of large-scale life models but often require the use of technically complex lower-level distributed computing frameworks, such as MPI. We propose to overcome the complexity challenge by applying the emerging MapReduce (MR) model to distributed life simulations and by running such simulations on the cloud. Technically, we design optimized MR streaming algorithms for discrete and continuous versions of Conway’s life according to a general MR streaming pattern. We chose life because it is simple enough as a testbed for MR’s applicability to a-life simulations and general enough to make our results applicable to various lattice-based a-life models. We implement and empirically evaluate our algorithms’ performance on Amazon’s Elastic MR cloud. Our experiments demonstrate that a single MR optimization technique called strip partitioning can reduce the execution time of continuous life simulations by 64%. To the best of our knowledge, we are the first to propose and evaluate MR streaming algorithms for lattice-based simulations. Our algorithms can serve as prototypes in the development of novel MR simulation algorithms for large-scale lattice-based a-life models.https://digitalcommons.chapman.edu/scs_books/1014/thumbnail.jp

Proceedings of the NASA Conference on Space Telerobotics, volume 3

The theme of the Conference was man-machine collaboration in space. The Conference provided a forum for researchers and engineers to exchange ideas on the research and development required for application of telerobotics technology to the space systems planned for the 1990s and beyond. The Conference: (1) provided a view of current NASA telerobotic research and development; (2) stimulated technical exchange on man-machine systems, manipulator control, machine sensing, machine intelligence, concurrent computation, and system architectures; and (3) identified important unsolved problems of current interest which can be dealt with by future research

Seventh Annual Workshop on Space Operations Applications and Research (SOAR 1993), volume 2

This document contains papers presented at the Space Operations, Applications and Research Symposium (SOAR) Symposium hosted by NASA/Johnson Space Center (JSC) and cosponsored by NASA/JSC and U.S. Air Force Materiel Command. SOAR included NASA and USAF programmatic overviews, plenary session, panel discussions, panel sessions, and exhibits. It invited technical papers in support of U.S. Army, U.S. Navy, Department of Energy, NASA, and USAF programs in the following areas: robotics and telepresence, automation and intelligent systems, human factors, life support, and space maintenance and servicing. SOAR was concerned with Government-sponsored research and development relevant to aerospace operations

NASA Tech Briefs, July/August 1986

Topic include: NASA TU Serv1ces; New Product Ideas; Electronic Components and Circuits; Electronic Systems; Materials; Computer Programs; Mechanics; Physical Sciences; Machinery; Fabrication Technology; Mathematics and Information Sciences; Life Sciences.

Advances in PET Detection of the Antitumor T Cell Response

Positron emission tomography (PET) is a powerful noninvasive imaging technique able to measure distinct biological processes in vivo by administration of a radiolabeled probe. Whole-body measurements track the probe accumulation providing a means to measure biological changes such as metabolism, cell location, or tumor burden. PET can also be applied to both preclinical and clinical studies providing three-dimensional information. For immunotherapies (in particular understanding T cell responses), PET can be utilized for spatial and longitudinal tracking of T lymphocytes. Although PET has been utilized clinically for over 30 years, the recent development of additional PET radiotracers have dramatically expanded the use of PET to detect endogenous or adoptively transferred T cells in vivo. Novel probes have identified changes in T cell quantity, location, and function. This has enabled investigators to track T cells outside of the circulation and in hematopoietic organs such as spleen, lymph nodes, and bone marrow, or within tumors. In this review, we cover advances in PET detection of the antitumor T cell response and areas of focus for future studies