Ranking Alternatives on the Basis of a Dominance Intensity Measure

The additive multi-attribute utility model is widely used within MultiAttribute Utility Theory (MAUT), demanding all the information describing the decision-making situation. However, these information requirements can obviously be far too strict in many practical situations. Consequently, incomplete information about input parameters has been incorporated into the decisionmaking process. We propose an approach based on a dominance intensity measure to deal with such situations. The approach is based on the dominance values between pairs of alternatives that can be computed by linear programming. These dominance values are transformed into dominance intensities from which a dominance intensity measure is derived. It is used to analyze the robustness of a ranking of technologies for the disposition of surplus weapons-grade plutonium by the Department of Energy in the USA, and compared with other dominance measuring methods

Optimal designs for enzyme inhibition kinetic models

In this paper we present a new method for determining optimal designs for enzyme inhibition kinetic models, which are used to model the influence of the concentration of a substrate and an inhibition on the velocity of a reaction. The approach uses a nonlinear transformation of the vector of predictors such that the model in the new coordinates is given by an incomplete response surface model. Although there exist no explicit solutions of the optimal design problem for incomplete response surface models so far, the corresponding design problem in the new coordinates is substantially more transparent, such that explicit or numerical solutions can be determined more easily. The designs for the original problem can finally be found by an inverse transformation of the optimal designs determined for the response surface model. We illustrate the method determining explicit solutions for the $D$-optimal design and for the optimal design problem for estimating the individual coefficients in a non-competitive enzyme inhibition kinetic model

Preliminary space mission design under uncertainty

This paper proposes a way to model uncertainties and to introduce them explicitly in the design process of a preliminary space mission. Traditionally, a system margin approach is used in order to take them into account. In this paper, Evidence Theory is proposed to crystallise the inherent uncertainties. The design process is then formulated as an Optimisation Under Uncertainties (OUU). Three techniques are proposed to solve the OUU problem: (a) an evolutionary multi-objective approach, (b) a step technique consisting of maximising the belief for different levels of performance, and (c) a clustering method that firstly identifes feasible regions. The three methods are applied to the BepiColombo mission and their effectiveness at solving the OUU problem are compared