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Functional Effects of let-7g Expression in Colon Cancer Metastasis.
MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment
The Incremental Multiresolution Matrix Factorization Algorithm
Multiresolution analysis and matrix factorization are foundational tools in
computer vision. In this work, we study the interface between these two
distinct topics and obtain techniques to uncover hierarchical block structure
in symmetric matrices -- an important aspect in the success of many vision
problems. Our new algorithm, the incremental multiresolution matrix
factorization, uncovers such structure one feature at a time, and hence scales
well to large matrices. We describe how this multiscale analysis goes much
farther than what a direct global factorization of the data can identify. We
evaluate the efficacy of the resulting factorizations for relative leveraging
within regression tasks using medical imaging data. We also use the
factorization on representations learned by popular deep networks, providing
evidence of their ability to infer semantic relationships even when they are
not explicitly trained to do so. We show that this algorithm can be used as an
exploratory tool to improve the network architecture, and within numerous other
settings in vision.Comment: Computer Vision and Pattern Recognition (CVPR) 2017, 10 page
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