Beyond Tissue replacement: The Emerging role of smart implants in healthcare

Smart implants are increasingly used to treat various diseases, track patient status, and restore tissue and organ function. These devices support internal organs, actively stimulate nerves, and monitor essential functions. With continuous monitoring or stimulation, patient observation quality and subsequent treatment can be improved. Additionally, using biodegradable and entirely excreted implant materials eliminates the need for surgical removal, providing a patient-friendly solution. In this review, we classify smart implants and discuss the latest prototypes, materials, and technologies employed in their creation. Our focus lies in exploring medical devices beyond replacing an organ or tissue and incorporating new functionality through sensors and electronic circuits. We also examine the advantages, opportunities, and challenges of creating implantable devices that preserve all critical functions. By presenting an in-depth overview of the current state-of-the-art smart implants, we shed light on persistent issues and limitations while discussing potential avenues for future advancements in materials used for these devices

Inductively Powered Implantable System with Far-field Data Transmitter for an Intracranial Pressure Monitoring Application: Design and Performance Validation

Monitoring of the intracranial pressure (ICP) is an essential activity for many brain diseases and injuries. For an adult, ICP value is between 7 mmHg to 15 mmHg . However, for a critically ill patient, the ICP should be maintained below 20 mmHg. Therefore, continuous monitoring of ICP is a life-saving activity. Several invasive and non-invasive methods have been proposed for monitoring of the ICP. However, invasive methods cannot be used for continuous monitoring of the ICP due to the risk of infection. Moreover, non-invasive methods lack in accuracy.Therefore, many researchers reported battery-powered or fully passive implantable systems. However, a battery-powered implant has limited life and large size. On the other hand, in a fully passive implant the readout distance is relatively small in comparison with a battery-powered implant due to its zero-power operation.In contrast, this work presents the development of an inductively powered implantable system equipped with a data transmission unit for an ICP monitoring application. The developed system has three main parts: an implant or in-body unit, an on-body unit and an off-body unit. The on-body unit powers the implant through inductive near-field link. After the activation, the implant, consists of a piezoresistive pressure sensor and a data transmission unit, transmits the pressure signal at the industrial, scientific, and medical radio (ISM) band of 2.45 GHz. The off-body unit receives the transmitted signal from the implant and estimates the pressure value.The simulation and the measurement results of both near-filed and far-field links are presented. After the development of the system, the pressue readout measurement results have been presented in the air, water and in a setting mimicking the human head dielectric properties. For biocompatibility, the implant is coated with biocompatible adhesive silicone. The effect of coating on both wireless links has also been studied.Finally, this work also presents the effect of misalignment between the inductively coupled antennas on the pressure readout accuracy of the developed ICP monitoring system and discusses the solution to overcome this impact. The thesis also presents the response of the developed ICP monitoring system with the change in the temperature

Non-invasive Monitoring of Brain Temperature during Rapid Selective Brain Cooling by Zero-Heat-Flux Thermometry

Introduction: Selective brain cooling can minimize systemic complications associated with whole body cooling but maximize neuroprotection. Recently, we developed a non-invasive, portable and inexpensive system for selectively cooling the brain rapidly and demonstrated its safety and efficacy in porcine models. However, the widespread application of this technique in the clinical setting requires a reliable, non-invasive and accurate method for measuring local brain temperature so that cooling and rewarming rates can be controlled during targeted temperature management. In this study, we evaluate the ability of a zero-heat-flux SpotOn sensor, mounted on three different locations, to measure brain temperature during selective brain cooling in a pig model. Computed Tomography (CT) was used to determine the position of the SpotOn patches relative to the brain at different placement locations. Methods and Results: Experiments were conducted on two juvenile pigs. Body temperature was measured using a rectal temperature probe while brain temperature with an intraparenchymal thermocouple probe. A SpotOn patch was taped to the pig’s head at three different locations: 1-2 cm posterior (Location #1, n=1), central forehead (Location #2, n=1); and 1-2 cm anterior and lateral to the bregma i.e., above the eye on the forehead (Location #3, n=1). This cooling system was able to rapidly cool the brain temperature to 33.7 ± 0.2°C within 15 minutes, and maintain the brain temperature within 33-34°C for 4-6 hours before slowly rewarming to 34.8 ± 1.1°C from 33.7 ± 0.2°C, while maintaining the core body temperature (as per rectal temperature probe) above 36°C. We measured a mean bias of -1.1°C, -0.2°C and 0.7°C during rapid cooling in induction phase, maintenance and rewarming phase, respectively. Amongst the three locations, location #2 had the highest correlation (R2 = 0.8) between the SpotOn sensor and the thermocouple probe. Conclusions: This SBC method is able to tightly control the rewarming rate within 0.52 ± 0.20°C/h. The SpotOn sensor placed on the center of the forehead provides a good measurement of brain temperature in comparison to the invasive needle probe

Transcranial optical monitoring for detecting intracranial pressure alterations in children with benign external hydrocephalus: a proof-of-concept study

Hydrocephalus; Optical techniques; PathophysiologyHidrocefalia; Técnicas ópticas; FisiopatologíaHidrocefàlia; Tècniques òptiques; FisiopatologiaSignificance Benign external hydrocephalus (BEH) is considered a self-limiting pathology with a good prognosis. However, some children present a pathological intracranial pressure (ICP) characterized by quantitative and qualitative alterations (the so-called B-waves) that can lead to neurological sequelae. Aim Our purpose was to evaluate whether there were cerebral hemodynamic changes associated with ICP B-waves that could be evaluated with noninvasive neuromonitoring. Approach We recruited eleven patients (median age 16 months, range 7 to 55 months) with BEH and an unfavorable evolution requiring ICP monitoring. Bedside, nocturnal monitoring using near-infrared time-resolved and diffuse correlation spectroscopies synchronized to the clinical monitoring was performed. Results By focusing on the timing of different ICP patterns that were identified manually by clinicians, we detected significant tissue oxygen saturation (StO2) changes (p = 0.002) and blood flow index (BFI) variability (p = 0.005) between regular and high-amplitude B-wave patterns. A blinded analysis looking for analogs of ICP patterns in BFI time traces achieved 90% sensitivity in identifying B-waves and 76% specificity in detecting the regular patterns. Conclusions We revealed the presence of StO2 and BFI variations—detectable with optical techniques—during ICP B-waves in BEH children. Finally, the feasibility of detecting ICP B-waves in hemodynamic time traces obtained noninvasively was shown.This work was realized with the support of the Department of Cirugía and Ciencias Morfológicas of the Universitat Autònoma de Barcelona. The work was supported by the European Union’s Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie (Grant No. 675332) (BitMap: brain injury and trauma monitoring using advanced photonics) and the European Union’s Horizon 2020 Research and Innovation Program [Grant No. 101017113 (TinyBrains) and Grant No. 101016087 (VASCOVID)]; Fondo de Investigación Sanitaria (Instituto de Salud Carlos III) (Grant No. PI18/00468); Fundació CELLEX Barcelona, Fundació Mir Puig, Agencia Estatal de Investigación (PHOTOMETABO, Grant No. PID2019106481RBC31); the “Severo Ochoa” Program for Centers of Excelence in R&D (Grant No. CEX2019-000910-S); the Obra social “La Caixa” Foundation (LlumMedBcn), Generalitat de Catalunya (CERCA, AGAUR-2017-SGR-1380, RIS3CAT-001-P-001682 CECH), FEDER EC and LASERLAB EUROPE V (EC H2020 No. 871124); KidsBrainIT (ERANET NEURON); Fundació La Marató de TV3 (Grant Nos. 201724.31 and 201709.31)

Fibre optic pressure sensors in healthcare applications

This PhD thesis provides an extensive description of the development of two fibre optic pressure sensors for applications in health care: (i) a miniature fibre optic Fabry–Perot pressure sensor for fluid pressure measurements in invasive blood pressure monitoring and; (ii) a highly sensitive fibre Bragg grating sensor for contact/interface pressure measurement. The fibre optic Fabry-Perot pressure sensor has a diameter of 125 μm and is created by forming a cavity at the tip of a single-mode optical fibre. Parylene films were used as the pressure-sensitive diaphragm. The performance of three sensors with different aspect ratios has been investigated. The pressure sensing range of ~10 kPa (diastolic pressure)- ~15 kPa (systolic pressure) was targeted; sensor with the cavity of 70 μm in diameter and cavity length of 87 μm is able to sense within a range of 0- 18 kPa with an average sensitivity of 0.12 nm/kPa and response time of 3 seconds. The temperature sensitivity of 0.084 nm/°C was observed. Hysteresis and wavelength drift were observed for the sensors, which may be due to the permeability of the Parylene film to the air. Solutions for reducing hysteresis, wavelength drift and temperature cross-sensitivity are discussed in detail. Fibre Bragg grating (FBG) sensor technology is an ideal candidate for contact pressure measurement in compression therapy, pressure ulcer or prosthetics due to its many advantages such as conforming to body parts, small size, biocompatibility and multiplexing capabilities. A successful mathematical model for an FBG contact pressure sensor for healthcare applications has been presented and experimentally validated. The model has been compared with previous studies reported in the literature and takes into account birefringence. The highest sensitivity was achieved for the disc shape with a sensitivity of 0.8719 nm/MPa for a diameter of 5.5 mm, thickness of 1 mm and Young’s modulus of 20 MPa. This sensor was comprised of a 3 mm long FBG 6 centrally located in the patch. This is a pressure sensitivity of ~270 times increase when compared with a bare FBG reported in the literature. Birefringence effect was observed for the disk patch for pressures larger than 2.6 MPa. Even though FBGs provide high sensitivity in contact pressure sensing in healthcare, the potential applications are limited by the size and cost of commercially available FBG interrogators. A successful first attempt towards the development of a single channel compact FBG interrogation was accomplished. The system consists of a three-section distributed Bragg Reflector (DBR) tuneable laser, microcontroller unit, precision 5 channel current driver IC, photodiode circuit and a temperature controller IC. The tuneable laser was calibrated within 1535-1544 nm wavelength range to produce three current–wavelength lookup tables for wavelength resolution of 1 nm, 0.1 nm, 0.01 nm which is dependent on the current resolution. Futureworkincludesaddingpowercircuitry, a photodiode circuit and a feedback circuit to minimize power fluctuations. The system was tested compared to the commercial Smartscope FBG interrogator

Flexible sensors for biomedical technology

Flexible sensing devices have gained a great deal of attention among the scientific community in recent years. The application of flexible sensors spans over several fields, including medicine, industrial automation, robotics, security, and human-machine interfacing. In particular, non-invasive health-monitoring devices are expected to play a key role in the improvement of patient life and in reducing costs associated with clinical and biomedical diagnostic procedures. Here, we focus on recent advances achieved in flexible devices applied on the human skin for biomedical and healthcare purposes

Fibre optic pressure sensors in healthcare applications

This PhD thesis provides an extensive description of the development of two fibre optic pressure sensors for applications in health care: (i) a miniature fibre optic Fabry–Perot pressure sensor for fluid pressure measurements in invasive blood pressure monitoring and; (ii) a highly sensitive fibre Bragg grating sensor for contact/interface pressure measurement. The fibre optic Fabry-Perot pressure sensor has a diameter of 125 μm and is created by forming a cavity at the tip of a single-mode optical fibre. Parylene films were used as the pressure-sensitive diaphragm. The performance of three sensors with different aspect ratios has been investigated. The pressure sensing range of ~10 kPa (diastolic pressure)- ~15 kPa (systolic pressure) was targeted; sensor with the cavity of 70 μm in diameter and cavity length of 87 μm is able to sense within a range of 0- 18 kPa with an average sensitivity of 0.12 nm/kPa and response time of 3 seconds. The temperature sensitivity of 0.084 nm/°C was observed. Hysteresis and wavelength drift were observed for the sensors, which may be due to the permeability of the Parylene film to the air. Solutions for reducing hysteresis, wavelength drift and temperature cross-sensitivity are discussed in detail. Fibre Bragg grating (FBG) sensor technology is an ideal candidate for contact pressure measurement in compression therapy, pressure ulcer or prosthetics due to its many advantages such as conforming to body parts, small size, biocompatibility and multiplexing capabilities. A successful mathematical model for an FBG contact pressure sensor for healthcare applications has been presented and experimentally validated. The model has been compared with previous studies reported in the literature and takes into account birefringence. The highest sensitivity was achieved for the disc shape with a sensitivity of 0.8719 nm/MPa for a diameter of 5.5 mm, thickness of 1 mm and Young’s modulus of 20 MPa. This sensor was comprised of a 3 mm long FBG 6 centrally located in the patch. This is a pressure sensitivity of ~270 times increase when compared with a bare FBG reported in the literature. Birefringence effect was observed for the disk patch for pressures larger than 2.6 MPa. Even though FBGs provide high sensitivity in contact pressure sensing in healthcare, the potential applications are limited by the size and cost of commercially available FBG interrogators. A successful first attempt towards the development of a single channel compact FBG interrogation was accomplished. The system consists of a three-section distributed Bragg Reflector (DBR) tuneable laser, microcontroller unit, precision 5 channel current driver IC, photodiode circuit and a temperature controller IC. The tuneable laser was calibrated within 1535-1544 nm wavelength range to produce three current–wavelength lookup tables for wavelength resolution of 1 nm, 0.1 nm, 0.01 nm which is dependent on the current resolution. Futureworkincludesaddingpowercircuitry, a photodiode circuit and a feedback circuit to minimize power fluctuations. The system was tested compared to the commercial Smartscope FBG interrogator

Summer 2014 Biomedical Engineering Newsletter

Table of Contents New IEEE, AIMBE and SPIE fellows Arteries on aisle 9 Implants with sensors that shake off infection Mitch Kirby wins Whitaker International Fellowship Skin patch warns when it’s time to get out of the sunhttps://digitalcommons.mtu.edu/biomedical-newsletters/1001/thumbnail.jp