Modeling the pulse signal by wave-shape function and analyzing by synchrosqueezing transform

We apply the recently developed adaptive non-harmonic model based on the wave-shape function, as well as the time-frequency analysis tool called synchrosqueezing transform (SST) to model and analyze oscillatory physiological signals. To demonstrate how the model and algorithm work, we apply them to study the pulse wave signal. By extracting features called the spectral pulse signature, {and} based on functional regression, we characterize the hemodynamics from the radial pulse wave signals recorded by the sphygmomanometer. Analysis results suggest the potential of the proposed signal processing approach to extract health-related hemodynamics features

Harmonic Sum-based Method for Heart Rate Estimation using PPG Signals Affected with Motion Artifacts

Wearable photoplethysmography has recently become a common technology in heart rate (HR) monitoring. General observation is that the motion artifacts change the statistics of the acquired PPG signal. Consequently, estimation of HR from such a corrupted PPG signal is challenging. However, if an accelerometer is also used to acquire the acceleration signal simultaneously, it can provide helpful information that can be used to reduce the motion artifacts in the PPG signal. By dint of repetitive movements of the subjects hands while running, the accelerometer signal is found to be quasi-periodic. Over short-time intervals, it can be modeled by a finite harmonic sum (HSUM). Using the HSUM model, we obtain an estimate of the instantaneous fundamental frequency of the accelerometer signal. Since the PPG signal is a composite of the heart rate information (that is also quasi-periodic) and the motion artifact, we fit a joint HSUM model to the PPG signal. One of the harmonic sums corresponds to the heart-beat component in PPG and the other models the motion artifact. However, the fundamental frequency of the motion artifact has already been determined from the accelerometer signal. Subsequently, the HR is estimated from the joint HSUM model. The mean absolute error in HR estimates was 0.7359 beats per minute (BPM) with a standard deviation of 0.8328 BPM for 2015 IEEE Signal Processing cup data. The ground-truth HR was obtained from the simultaneously acquired ECG for validating the accuracy of the proposed method. The proposed method is compared with four methods that were recently developed and evaluated on the same dataset

How Nonlinear-Type Time-Frequency Analysis Can Help in Sensing Instantaneous Heart Rate and Instantaneous Respiratory Rate from Photoplethysmography in a Reliable Way

Despite the population of the noninvasive, economic, comfortable, and easy-to-install photoplethysmography (PPG), it is still lacking a mathematically rigorous and stable algorithm which is able to simultaneously extract from a single-channel PPG signal the instantaneous heart rate (IHR) and the instantaneous respiratory rate (IRR). In this paper, a novel algorithm called deppG is provided to tackle this challenge. deppG is composed of two theoretically solid nonlinear-type time-frequency analyses techniques, the de-shape short time Fourier transform and the synchrosqueezing transform, which allows us to extract the instantaneous physiological information from the PPG signal in a reliable way. To test its performance, in addition to validating the algorithm by a simulated signal and discussing the meaning of “instantaneous,” the algorithm is applied to two publicly available batch databases, the Capnobase and the ICASSP 2015 signal processing cup. The former contains PPG signals relative to spontaneous or controlled breathing in static patients, and the latter is made up of PPG signals collected from subjects doing intense physical activities. The accuracies of the estimated IHR and IRR are compared with the ones obtained by other methods, and represent the state-of-the-art in this field of research. The results suggest the potential of deppG to extract instantaneous physiological information from a signal acquired from widely available wearable devices, even when a subject carries out intense physical activities

Signal processing techniques for cardiovascular monitoring applications using conventional and video-based photoplethysmography

Photoplethysmography (PPG)-based monitoring devices will probably play a decisive role in healthcare environment of the future, which will be preventive, predictive, personalized and participatory. Indeed, this optical technology presents several practical advantages over gold standard methods based on electrocardiography, because PPG wearable devices can be comfortably used for long-term continuous monitoring during daily life activities. Contactless video-based PPG technique, also known as imaging photoplethysmography (iPPG), has also attracted much attention recently. In that case, the cardiac pulse is remotely measured from the subtle skin color changes resulting from the blood circulation, using a simple video camera. PPG/iPPG have a lot of potential for a wide range of cardiovascular applications. Hence, there is a substantial need for signal processing techniques to explore these applications and to improve the reliability of the PPG/iPPG-based parameters. \par A part of the thesis is dedicated to the development of robust processing schemes to estimate heart rate from the PPG/iPPG signals. The proposed approaches were built on adaptive frequency tracking algorithms that were previously developed in our group. These tools, based on adaptive band-pass filters, provide instantaneous frequency estimates of the input signal(s) with a very low time delay, making them suitable for real-time applications. In case of conventional PPG, a prior adaptive noise cancellation step involving the use of accelerometer signals was also necessary to reconstruct clean PPG signals during the regions corrupted by motion artifacts. Regarding iPPG, after comparing different regions of interest on the subject face, we hypothesized that the simultaneous use of different iPPG signal derivation methods (i.e. methods to derive the iPPG time series from the pixel values of the consecutive frames) could be advantageous. Methods to assess signal quality online and to incorporate it into instantaneous frequency estimation were also examined and successfully applied to improve system reliability. \par This thesis also explored different innovative applications involving PPG/iPPG signals. The detection of atrial fibrillation was studied. Novel features derived directly from the PPG waveforms, designed to reflect the morphological changes observed during arrhythmic episodes, were proposed and proven to be successful for atrial fibrillation detection. Arrhythmia detection and robust heart rate estimation approaches were combined in another study aimed at reducing the number of false arrhythmia alarms in the intensive care unit by exploiting signals from independent sources, including PPG. Evaluation on a hidden dataset demonstrated that the number of false alarms was drastically reduced while almost no true alarm was suppressed. Finally, other aspects of the iPPG technology were examined, such as the measurement of pulse rate variability indexes from the iPPG signals and the estimation of respiratory rate from the iPPG interbeat intervals

Heart Rate Estimation During Physical Exercise Using Wrist-Type Ppg Sensors

Accurate heart rate monitoring during intense physical exercise is a challenging problem due to the high levels of motion artifacts (MA) in photoplethysmography (PPG) sensors. PPG is a non-invasive optical sensor that is being used in wearable devices to measure blood flow changes using the property of light reflection and absorption, allowing the extraction of vital signals such as the heart rate (HR). However, the sensor is susceptible to MA which increases during physical activity. This occurs since the frequency range of movement and HR overlaps, difficulting correct HR estimation. For this reason, MA removal has remained an active topic under research. Several approaches have been developed in the recent past and among these, a Kalman filter (KF) based approach showed promising results for an accurate estimation and tracking using PPG sensors. However, this previous tracker was demonstrated for a particular dataset, with manually tuned parameters. Moreover, such trackers do not account for the correct method for fusing data. Such a custom approach might not perform accurately in practical scenarios, where the amount of MA and the heart rate variability (HRV) depend on numerous, unpredictable factors. Thus, an approach to automatically tune the KF based on the Expectation-Maximization (EM) algorithm, with a measurement fusion approach is developed. The applicability of such a method is demonstrated using an open-source PPG database, as well as a developed synthetic generation tool that models PPG and accelerometer (ACC) signals during predetermined physical activities

Systems and methods for physiological signal enhancement and biometric extraction using non-invasive optical sensors

A system and method for signal processing to remove unwanted noise components including: (i) wavelength-independent motion artifacts such as tissue, bone and skin effects, and (ii) wavelength-dependent motion artifact/noise components such as venous blood pulsation and movement due to various sources including muscle pump, respiratory pump and physical perturbation. Disclosed are methods, analytics, and their uses for reliable perfusion monitoring, arterial oxygen saturation monitoring, heart rate monitoring during daily activities and in hospital settings and for extraction of physiological parameters such as respiration information, hemodynamic parameters, venous capacity, and fluid responsiveness. The system and methods disclosed are extendable to include monitoring platforms for perfusion, hypoxia, arrhythmia detection, airway obstruction detection and sleep disorders including apnea.Board of Regents, University of Texas Syste