Chimeranet: U-Net for Hair Detection in Dermoscopic Skin Lesion Images

Hair and ruler mark structures in dermoscopic images are an obstacle preventing accurate image segmentation and detection of critical network features. Recognition and removal of hairs from images can be challenging, especially for hairs that are thin, overlapping, faded, or of similar color as skin or overlaid on a textured lesion. This paper proposes a novel deep learning (DL) technique to detect hair and ruler marks in skin lesion images. Our proposed ChimeraNet is an encoder-decoder architecture that employs pretrained EfficientNet in the encoder and squeeze-and-excitation residual (SERes) structures in the decoder. We applied this approach at multiple image sizes and evaluated it using the publicly available HAM10000 (ISIC2018 Task 3) skin lesion dataset. Our test results show that the largest image size (448 x 448) gave the highest accuracy of 98.23 and Jaccard index of 0.65 on the HAM10000 (ISIC 2018 Task 3) skin lesion dataset, exhibiting better performance than for two well-known deep learning approaches, U-Net and ResUNet-a. We found the Dice loss function to give the best results for all measures. Further evaluated on 25 additional test images, the technique yields state-of-the-art accuracy compared to 8 previously reported classical techniques. We conclude that the proposed ChimeraNet architecture may enable improved detection of fine image structures. Further application of DL techniques to detect dermoscopy structures is warranted

Medical image synthesis using generative adversarial networks: towards photo-realistic image synthesis

This proposed work addresses the photo-realism for synthetic images. We introduced a modified generative adversarial network: StencilGAN. It is a perceptually-aware generative adversarial network that synthesizes images based on overlaid labelled masks. This technique can be a prominent solution for the scarcity of the resources in the healthcare sector

Applications of Capacitive Imaging in Human Skin Texture and Hair Analysis

This article focuses on the extraction of information from human skin and scalp hair for evaluation of a subject’s condition in the cosmetic and pharmaceutical industries. It uses capacitive images from existing hand-held research equipment and it applies image processing algorithms to expand their possible applications. The literature review introduces the readers into the field of skin research, and it highlights pieces of information that can be extracted by in vivo skin and ex vivo hair measurements. Then, the selected scientific equipment is presented, and Maxwell-based electrostatic simulations are employed to evaluate the measurement apparatus. Image analysis algorithms are suggested for (a) the detection of polygons on the human skin texture, (b) the estimation of wrinkles length and (c) the observation of hair water sorption capabilities by capacitive imaging systems. Finally, experiments are conducted to evaluate the performance of the presented algorithms and the results are compared with the literature. The results indicate that capacitive imaging systems can be used for skin age classification, detection and tracking of skin artifacts (e.g., wrinkles, moles or scars) and calculation of water content in hair samples

Towards PACE-CAD Systems

Despite phenomenal advancements in the availability of medical image datasets and the development of modern classification algorithms, Computer-Aided Diagnosis (CAD) has had limited practical exposure in the real-world clinical workflow. This is primarily because of the inherently demanding and sensitive nature of medical diagnosis that can have far-reaching and serious repercussions in case of misdiagnosis. In this work, a paradigm called PACE (Pragmatic, Accurate, Confident, & Explainable) is presented as a set of some of must-have features for any CAD. Diagnosis of glaucoma using Retinal Fundus Images (RFIs) is taken as the primary use case for development of various methods that may enrich an ordinary CAD system with PACE. However, depending on specific requirements for different methods, other application areas in ophthalmology and dermatology have also been explored. Pragmatic CAD systems refer to a solution that can perform reliably in day-to-day clinical setup. In this research two, of possibly many, aspects of a pragmatic CAD are addressed. Firstly, observing that the existing medical image datasets are small and not representative of images taken in the real-world, a large RFI dataset for glaucoma detection is curated and published. Secondly, realising that a salient attribute of a reliable and pragmatic CAD is its ability to perform in a range of clinically relevant scenarios, classification of 622 unique cutaneous diseases in one of the largest publicly available datasets of skin lesions is successfully performed. Accuracy is one of the most essential metrics of any CAD system's performance. Domain knowledge relevant to three types of diseases, namely glaucoma, Diabetic Retinopathy (DR), and skin lesions, is industriously utilised in an attempt to improve the accuracy. For glaucoma, a two-stage framework for automatic Optic Disc (OD) localisation and glaucoma detection is developed, which marked new state-of-the-art for glaucoma detection and OD localisation. To identify DR, a model is proposed that combines coarse-grained classifiers with fine-grained classifiers and grades the disease in four stages with respect to severity. Lastly, different methods of modelling and incorporating metadata are also examined and their effect on a model's classification performance is studied. Confidence in diagnosing a disease is equally important as the diagnosis itself. One of the biggest reasons hampering the successful deployment of CAD in the real-world is that medical diagnosis cannot be readily decided based on an algorithm's output. Therefore, a hybrid CNN architecture is proposed with the convolutional feature extractor trained using point estimates and a dense classifier trained using Bayesian estimates. Evaluation on 13 publicly available datasets shows the superiority of this method in terms of classification accuracy and also provides an estimate of uncertainty for every prediction. Explainability of AI-driven algorithms has become a legal requirement after Europe’s General Data Protection Regulations came into effect. This research presents a framework for easy-to-understand textual explanations of skin lesion diagnosis. The framework is called ExAID (Explainable AI for Dermatology) and relies upon two fundamental modules. The first module uses any deep skin lesion classifier and performs detailed analysis on its latent space to map human-understandable disease-related concepts to the latent representation learnt by the deep model. The second module proposes Concept Localisation Maps, which extend Concept Activation Vectors by locating significant regions corresponding to a learned concept in the latent space of a trained image classifier. This thesis probes many viable solutions to equip a CAD system with PACE. However, it is noted that some of these methods require specific attributes in datasets and, therefore, not all methods may be applied on a single dataset. Regardless, this work anticipates that consolidating PACE into a CAD system can not only increase the confidence of medical practitioners in such tools but also serve as a stepping stone for the further development of AI-driven technologies in healthcare

Combining local features and region segmentation: methods and applications

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Escuela Politécnica Superior, Departamento de Tecnología Electrónica y de las Comunicaciones. Fecha de lectura: 23-01-2020Esta tesis tiene embargado el acceso al texto completo hasta el 23-07-2021Muchas y muy diferentes son las propuestas que se han desarrollado en el área de la visión artificial para la extracción de información de las imágenes y su posterior uso. Entra las más destacadas se encuentran las conocidas como características locales, del inglés local features, que detectan puntos o áreas de la imagen con ciertas características de interés, y las describen usando información de su entorno (local). También destacan las regiones en este área, y en especial este trabajo se ha centrado en los segmentadores en regiones, cuyo objetivo es agrupar la información de la imagen atendiendo a diversos criterios. Pese al enorme potencial de estas técnicas, y su probado éxito en diversas aplicaciones, su definición lleva implícita una serie de limitaciones funcionales que les han impedido exportar sus capacidades a otras áreas de aplicación. Se pretende impulsar el uso de estas herramientas en dichas aplicaciones, y por tanto mejorar los resultados del estado del arte, mediante la propuesta de un marco de desarrollo de nuevas soluciones. En concreto, la hipótesis principal del proyecto es que las capacidades de las características locales y los segmentadores en regiones son complementarias, y que su combinación, realizada de la forma adecuada, las maximiza a la vez que minimiza sus limitaciones. El principal objetivo, y por tanto la principal contribución del proyecto, es validar dicha hipótesis mediante la propuesta de un marco de desarrollo de nuevas soluciones combinando características locales y segmentadores para técnicas con capacidades mejoradas. Al tratarse de un marco de combinación de dos técnicas, el proceso de validación se ha llevado a cabo en dos pasos. En primer lugar se ha planteado el caso del uso de segmentadores en regiones para mejorar las características locales. Para verificar la viabilidad y el éxito de esta combinación se ha desarrollado una propuesta específica, SP-SIFT, que se ha validado tanto a nivel experimental como a nivel de aplicación real, en concreto como técnica principal de algoritmos de seguimiento de objetos. En segundo lugar, se ha planteado el caso de uso de características locales para mejorar los segmentadores en regiones. Para verificar la viabilidad y el éxito de esta combinación se ha desarrollado una propuesta específica, LF-SLIC, que se ha validado tanto a nivel experimental como a nivel de aplicación real, en concreto como técnica principal de un algoritmo de segmentación de lesiones pigmentadas de la piel. Los resultados conceptuales han probado que las técnicas mejoran a nivel de capacidades. Los resultados aplicados han probado que estas mejoras permiten el uso de estas técnicas en aplicaciones donde antes no tenían éxito. Con ello, se ha considerado la hipótesis validada, y por tanto exitosa la definición de un marco para el desarrollo de nuevas técnicas específicas con capacidades mejoradas. En conclusión, la principal aportación de la tesis es el marco de combinación de técnicas, plasmada en sus dos propuestas específicas: características locales mejoradas con segmentadores y segmentadores mejorados con características locales, y en el éxito conseguido en sus aplicaciones.A huge number of proposals have been developed in the area of computer vision for information extraction from images, and its further use. One of the most prevalent solutions are those known as local features. They detect points or areas of the image with certain characteristics of interest, and describe them using information from their (local) environment. The regions also stand out in the area, and especially this work has focused on the region segmentation algorithms, whose objective is to group the information of the image according to di erent criteria. Despite the enormous potential of these techniques, and their proven success in a number of applications, their de nition implies a series of functional limitations that have prevented them from exporting their capabilities to other application areas. In this thesis, it is intended to promote the use of these tools in these applications, and therefore improve the results of the state of the art, by proposing a framework for developing new solutions. Speci cally, the main hypothesis of the project is that the capacities of the local features and the region segmentation algorithms are complementary, and thus their combination, carried out in the right way, maximizes them while minimizing their limitations. The main objective, and therefore the main contribution of the thesis, is to validate this hypothesis by proposing a framework for developing new solutions combining local features and region segmentation algorithms, obtaining solutions with improved capabilities. As the hypothesis is proposing to combine two techniques, the validation process has been carried out in two steps. First, the use case of region segmentation algorithms enhancing local features. In order to verify the viability and success of this combination, a speci c proposal, SP-SIFT, was been developed. This proposal was validated both experimentally and in a real application scenario, speci cally as the main technique of object tracking algorithms. Second, the use case of enhancing region segmentation algorithm with local features. In order to verify the viability and success of this combination, a speci c proposal, LF-SLIC, was developed. The proposal was validated both experimentally and in a real application scenario, speci cally as the main technique of a pigmented skin lesions segmentation algorithm. The conceptual results proved that the techniques improve at the capabilities level. The application results proved that these improvements allow the use of this techniques in applications where they were previously unsuccessful. Thus, the hypothesis can be considered validated, and therefore the de nition of a framework for the development of new techniques with improved capabilities can be considered successful. In conclusion, the main contribution of the thesis is the framework for the combination of techniques, embodied in the two speci c proposals: enhanced local features with region segmentation algorithms, and region segmentation algorithms enhanced with local features; and in the success achieved in their applications.The work described in this Thesis was carried out within the Video Processing and Understanding Lab at the Department of Tecnología Electrónica y de las Comunicaciones, Escuela Politécnica Superior, Universidad Autónoma de Madrid (from 2014 to 2019). It was partially supported by the Spanish Government (TEC2014-53176-R, HAVideo)