91,726 research outputs found
On the Effect of Inter-observer Variability for a Reliable Estimation of Uncertainty of Medical Image Segmentation
Uncertainty estimation methods are expected to improve the understanding and
quality of computer-assisted methods used in medical applications (e.g.,
neurosurgical interventions, radiotherapy planning), where automated medical
image segmentation is crucial. In supervised machine learning, a common
practice to generate ground truth label data is to merge observer annotations.
However, as many medical image tasks show a high inter-observer variability
resulting from factors such as image quality, different levels of user
expertise and domain knowledge, little is known as to how inter-observer
variability and commonly used fusion methods affect the estimation of
uncertainty of automated image segmentation. In this paper we analyze the
effect of common image label fusion techniques on uncertainty estimation, and
propose to learn the uncertainty among observers. The results highlight the
negative effect of fusion methods applied in deep learning, to obtain reliable
estimates of segmentation uncertainty. Additionally, we show that the learned
observers' uncertainty can be combined with current standard Monte Carlo
dropout Bayesian neural networks to characterize uncertainty of model's
parameters.Comment: Appears in Medical Image Computing and Computer Assisted
Interventions (MICCAI), 201
Single-image Tomography: 3D Volumes from 2D Cranial X-Rays
As many different 3D volumes could produce the same 2D x-ray image, inverting
this process is challenging. We show that recent deep learning-based
convolutional neural networks can solve this task. As the main challenge in
learning is the sheer amount of data created when extending the 2D image into a
3D volume, we suggest firstly to learn a coarse, fixed-resolution volume which
is then fused in a second step with the input x-ray into a high-resolution
volume. To train and validate our approach we introduce a new dataset that
comprises of close to half a million computer-simulated 2D x-ray images of 3D
volumes scanned from 175 mammalian species. Applications of our approach
include stereoscopic rendering of legacy x-ray images, re-rendering of x-rays
including changes of illumination, view pose or geometry. Our evaluation
includes comparison to previous tomography work, previous learning methods
using our data, a user study and application to a set of real x-rays
Medical image computing and computer-aided medical interventions applied to soft tissues. Work in progress in urology
Until recently, Computer-Aided Medical Interventions (CAMI) and Medical
Robotics have focused on rigid and non deformable anatomical structures.
Nowadays, special attention is paid to soft tissues, raising complex issues due
to their mobility and deformation. Mini-invasive digestive surgery was probably
one of the first fields where soft tissues were handled through the development
of simulators, tracking of anatomical structures and specific assistance
robots. However, other clinical domains, for instance urology, are concerned.
Indeed, laparoscopic surgery, new tumour destruction techniques (e.g. HIFU,
radiofrequency, or cryoablation), increasingly early detection of cancer, and
use of interventional and diagnostic imaging modalities, recently opened new
challenges to the urologist and scientists involved in CAMI. This resulted in
the last five years in a very significant increase of research and developments
of computer-aided urology systems. In this paper, we propose a description of
the main problems related to computer-aided diagnostic and therapy of soft
tissues and give a survey of the different types of assistance offered to the
urologist: robotization, image fusion, surgical navigation. Both research
projects and operational industrial systems are discussed
Deep Learning in Cardiology
The medical field is creating large amount of data that physicians are unable
to decipher and use efficiently. Moreover, rule-based expert systems are
inefficient in solving complicated medical tasks or for creating insights using
big data. Deep learning has emerged as a more accurate and effective technology
in a wide range of medical problems such as diagnosis, prediction and
intervention. Deep learning is a representation learning method that consists
of layers that transform the data non-linearly, thus, revealing hierarchical
relationships and structures. In this review we survey deep learning
application papers that use structured data, signal and imaging modalities from
cardiology. We discuss the advantages and limitations of applying deep learning
in cardiology that also apply in medicine in general, while proposing certain
directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table
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