10,068 research outputs found
ABCD Neurocognitive Prediction Challenge 2019: Predicting individual residual fluid intelligence scores from cortical grey matter morphology
We predicted residual fluid intelligence scores from T1-weighted MRI data
available as part of the ABCD NP Challenge 2019, using morphological similarity
of grey-matter regions across the cortex. Individual structural covariance
networks (SCN) were abstracted into graph-theory metrics averaged over nodes
across the brain and in data-driven communities/modules. Metrics included
degree, path length, clustering coefficient, centrality, rich club coefficient,
and small-worldness. These features derived from the training set were used to
build various regression models for predicting residual fluid intelligence
scores, with performance evaluated both using cross-validation within the
training set and using the held-out validation set. Our predictions on the test
set were generated with a support vector regression model trained on the
training set. We found minimal improvement over predicting a zero residual
fluid intelligence score across the sample population, implying that structural
covariance networks calculated from T1-weighted MR imaging data provide little
information about residual fluid intelligence.Comment: 8 pages plus references, 3 figures, 2 tables. Submission to the ABCD
Neurocognitive Prediction Challenge at MICCAI 201
Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction.
Recent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functional magnetic resonance imaging (MRI and fMRI, respectively) as well as diffusion tensor imaging (DTI) has excellent potential to identify novel biomarkers and predictors of TBI outcome. This is particularly the case when such methods are appropriately combined with volumetric/morphometric analysis of brain structures and with the exploration of TBI-related changes in brain network properties at the level of the connectome. In this context, our present review summarizes recent developments on the roles of these two techniques in the search for novel structural neuroimaging biomarkers that have TBI outcome prognostication value. The themes being explored cover notable trends in this area of research, including (1) the role of advanced MRI processing methods in the analysis of structural pathology, (2) the use of brain connectomics and network analysis to identify outcome biomarkers, and (3) the application of multivariate statistics to predict outcome using neuroimaging metrics. The goal of the review is to draw the community's attention to these recent advances on TBI outcome prediction methods and to encourage the development of new methodologies whereby structural neuroimaging can be used to identify biomarkers of TBI outcome
Experimental Design Modulates Variance in BOLD Activation: The Variance Design General Linear Model
Typical fMRI studies have focused on either the mean trend in the
blood-oxygen-level-dependent (BOLD) time course or functional connectivity
(FC). However, other statistics of the neuroimaging data may contain important
information. Despite studies showing links between the variance in the BOLD
time series (BV) and age and cognitive performance, a formal framework for
testing these effects has not yet been developed. We introduce the Variance
Design General Linear Model (VDGLM), a novel framework that facilitates the
detection of variance effects. We designed the framework for general use in any
fMRI study by modeling both mean and variance in BOLD activation as a function
of experimental design. The flexibility of this approach allows the VDGLM to i)
simultaneously make inferences about a mean or variance effect while
controlling for the other and ii) test for variance effects that could be
associated with multiple conditions and/or noise regressors. We demonstrate the
use of the VDGLM in a working memory application and show that engagement in a
working memory task is associated with whole-brain decreases in BOLD variance.Comment: 18 pages, 7 figure
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