Modified lambert beer for bilirubin concentration and blood oxygen saturation prediction

Noninvasive measurement of health parameters such as blood oxygen saturation and bilirubin concentration predicted via an appropriate light reflectance model based on the measured optical signals is of eminent interest in biomedical research. This is to replace the use of conventional invasive blood sampling approach. This study aims to investigate the feasibility of using Modified Lambert Beer model (MLB) in the prediction of one’s bilirubin concentration and blood oxygen saturation value, SO2. This quantification technique is based on a priori knowledge of extinction coefficients of bilirubin and hemoglobin derivatives in the wavelength range of 440 – 500 nm. The validity of the prediction was evaluated using light reflectance data from TracePro raytracing software for a single-layered skin model with varying bilirubin concentration. The results revealed some promising trends in the estimated bilirubin concentration with mean ± standard deviation (SD) error of 0.255 ± 0.025 g/l. Meanwhile, a remarkable low mean ± SD error of 9.11 ± 2.48 % was found for the predicted SO2 value. It was concluded that these errors are likely due to the insufficiency of the MLB at describing changes in the light attenuation with the underlying light absorption processes. In addition, this study also suggested the use of a linear regression model deduced from this work for an improved prediction of the required health parameter values

Applications and Experiences of Quality Control

The rich palette of topics set out in this book provides a sufficiently broad overview of the developments in the field of quality control. By providing detailed information on various aspects of quality control, this book can serve as a basis for starting interdisciplinary cooperation, which has increasingly become an integral part of scientific and applied research

2016 Oklahoma Research Day Full Program

This document contains all abstracts from the 2016 Oklahoma Research Day held at Northeastern State University

Applications of Monte Carlo Methods in Biology, Medicine and Other Fields of Science

This volume is an eclectic mix of applications of Monte Carlo methods in many fields of research should not be surprising, because of the ubiquitous use of these methods in many fields of human endeavor. In an attempt to focus attention on a manageable set of applications, the main thrust of this book is to emphasize applications of Monte Carlo simulation methods in biology and medicine

Aplicacion de modelos matematicos para el mantenimiento predictivo

149 p.La presente memoria de tesis presenta una revisión sobre la actividad de investigación aplicada que se ha realizado mediante varios proyectos relacionados con el mantenimiento predictivo asociado a procesos industriales. Uno de los resultados principales es la realización de una herramienta web que permite al operador consultar el tiempo estimado hasta el fallo en un proceso de mecanizado y junto a ello un histórico de datos del sistema. Se han obtenido otros resultados que generan una evolución en el mantenimiento de los sistemas estudiados, lo que reduce el coste y aumenta la productividad de estos. Para ello se han aplicado metodologías híbridas donde el objetivo principal radicaba en la creación de una metodología de mantenimiento predictivo para cada uno de los procesos y en algún caso la posibilidad de generalización de esta a procesos similares

Aplicacion de modelos matematicos para el mantenimiento predictivo

149 p.La presente memoria de tesis presenta una revisión sobre la actividad de investigación aplicada que se ha realizado mediante varios proyectos relacionados con el mantenimiento predictivo asociado a procesos industriales. Uno de los resultados principales es la realización de una herramienta web que permite al operador consultar el tiempo estimado hasta el fallo en un proceso de mecanizado y junto a ello un histórico de datos del sistema. Se han obtenido otros resultados que generan una evolución en el mantenimiento de los sistemas estudiados, lo que reduce el coste y aumenta la productividad de estos. Para ello se han aplicado metodologías híbridas donde el objetivo principal radicaba en la creación de una metodología de mantenimiento predictivo para cada uno de los procesos y en algún caso la posibilidad de generalización de esta a procesos similares

Mobile Measurement system for clinical diagnosis: A Transepidermal Water Loss Probe

Transepidermal water loss (TEWL) is commonly used as a surrogate marker for skin barrier function. Although current devices enable TEWL to be measured with ease and precision under controlled laboratory conditions, they do not yield reliable readings in an uncontrolled environment. This project aimed to develop a new TEWL device that is mobile, i.e. that would fit in the pocket and measure TEWL anywhere. For this, the prototype had to be portable, wireless and to have good autonomy. In addition the prototype performances were evaluated in terms of repeatability and sensitivity. The primary design is based on a closed-chamber to limit the effect of the environment. Moreover, the use of a fan to remove surface water and homogenise the micro-climate in the chamber was introduced. Mathematical modelling and measurements of water vapour and heat flux in closed TEWL chambers of a range of geometries was investigated to establish ideal sensors locations and blower flow rates. It was found that the fan decreased repeatability but increased sensitivity. In addition, it decreased coefficient of variation of measurements on moist skin, contrary to other TEWL chamber methods. Furthermore, lower fan speed yielded better precision. Finally, the gradient calculation is the crucial part of a TEWL measurement and Least Square Fitting was used to stabilise the readings and improve repeatability at the expense of computational speed. The work suggests that it should be possible to develop a viable new design that can generate measurements in the field that are easy to make and reliable but further work is needed to establish accuracy evaluation from a calibration with a fixed quantity of water and to develop a full commercial product