Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry. In an analysis that controlled for gender and population structure, ulcerative colitis loci attaining genome-wide significance and subsequent replication in two independent populations were identified on chromosomes 1p36 (rs6426833, combined P = 5.1 x 10(-13), combined odds ratio OR = 0.73) and 12q15 (rs1558744, combined P = 2.5 x 10(-12), combined OR = 1.35). In addition, combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 (rs2395185, combined P = 1.0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)

Feeling the future: A meta-analysis of 90 experiments on the anomalous anticipation of random future events

In 2011, one of the authors (DJB) published a report of nine experiments in the Journal of Personality and Social Psychology purporting to demonstrate that an individual\u2019s cognitive and affective responses can be influenced by randomly selected stimulus events that do not occur until after his or her responses have already been made and recorded, a generalized variant of the phenomenon traditionally denoted by the term precognition. To encourage replications, all materials needed to conduct them were made available on request. We here report a meta-analysis of 90 experiments from 33 laboratories in 14 countries which yielded an overall effect greater than 6 sigma, z = 6.40, p = 1.2 7 10 with an effect size (Hedges\u2019 g) of 0.09. A Bayesian analysis yielded a Bayes Factor of 5.1 7 10 , greatly exceeding the criterion value of 100 for \u201cdecisive evidence\u201d in support of the experimental hypothesis. When DJB\u2019s original experiments are excluded, the combined effect size for replications by independent investigators is 0.06, z = 4.16, p = 1.1 7 10 , and the BF value is 3,853, again exceeding the criterion for \u201cdecisive evidence.\u201d The number of potentially unretrieved experiments required to reduce the overall effect size of the complete database to a trivial value of 0.01 is 544, and seven of eight additional statistical tests support the conclusion that the database is not significantly compromised by either selection bias or by intense \u201cp -hacking\u201d\u2014the selective suppression of findings or analyses that failed to yield statistical significance. P-curve analysis, a recently introduced statistical technique, estimates the true effect size of the experiments to be 0.20 for the complete database and 0.24 for the independent replications, virtually identical to the effect size of DJB\u2019s original experiments (0.22) and the closely related \u201cpresentiment\u201d experiments (0.21). We discuss the controversial status of precognition and other anomalous effects collectively known as psi

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Genetic factors have been implicated in stroke risk but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its subtypes in 3,548 cases and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 cases and 6,281 controls. We replicated reported associations between variants close to PITX2 and ZFHX3 with cardioembolic stroke, and a 9p21 locus with large vessel stroke. We identified a novel association for a SNP within the histone deacetylase 9(HDAC9) gene on chromosome 7p21.1 which was associated with large vessel stroke including additional replication in a further 735 cases and 28583 controls (rs11984041, combined P = 1.87×10−11, OR=1.42 (95% CI) 1.28-1.57). All four loci exhibit evidence for heterogeneity of effect across the stroke subtypes, with some, and possibly all, affecting risk for only one subtype. This suggests differing genetic architectures for different stroke subtypes

DOH: A Content Delivery Peer-to-Peer Network

Many SMEs and non-pro¯t organizations su®er when their Web servers become unavailable due to °ash crowd e®ects when their web site becomes popular. One of the solutions to the °ash-crowd problem is to place the web site on a scalable CDN (Content Delivery Network) that replicates the content and distributes the load in order to improve its response time. In this paper, we present our approach to building a scalable Web Hosting environment as a CDN on top of a structured peer-to-peer system of collaborative web-servers integrated to share the load and to improve the overall system performance, scalability, availability and robustness. Unlike clusterbased solutions, it can run on heterogeneous hardware, over geographically dispersed areas. To validate and evaluate our approach, we have developed a system prototype called DOH (DKS Organized Hosting) that is a CDN implemented on top of the DKS (Distributed K-nary Search) structured P2P system with DHT (Distributed Hash table) functionality [9]. The prototype is implemented in Java, using the DKS middleware, the Jetty web-server, and a modi¯ed JavaFTP server. The proposed design of CDN has been evaluated by simulation and by evaluation experiments on the prototype

Notes from data flow workshop

Copyright @ 2009 MICEThis document summarises the discussions at the MICE Data Flow Workshop held at Brunel University on 30th June 2009. Background information about job submission and file storage on the Grid can be found in previous MICE Notes and the references therein. In particular the first two sections of Note 247 are meant to provide a gentle introduction to Grid data storage from the MICE perspective, and timid MICE may wish to read those first. The proposed data flow is described in MICE Note 252