Histopathological image analysis : a review

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe

Interactive inspection of complex multi-object industrial assemblies

The final publication is available at Springer via http://dx.doi.org/10.1016/j.cad.2016.06.005The use of virtual prototypes and digital models containing thousands of individual objects is commonplace in complex industrial applications like the cooperative design of huge ships. Designers are interested in selecting and editing specific sets of objects during the interactive inspection sessions. This is however not supported by standard visualization systems for huge models. In this paper we discuss in detail the concept of rendering front in multiresolution trees, their properties and the algorithms that construct the hierarchy and efficiently render it, applied to very complex CAD models, so that the model structure and the identities of objects are preserved. We also propose an algorithm for the interactive inspection of huge models which uses a rendering budget and supports selection of individual objects and sets of objects, displacement of the selected objects and real-time collision detection during these displacements. Our solution–based on the analysis of several existing view-dependent visualization schemes–uses a Hybrid Multiresolution Tree that mixes layers of exact geometry, simplified models and impostors, together with a time-critical, view-dependent algorithm and a Constrained Front. The algorithm has been successfully tested in real industrial environments; the models involved are presented and discussed in the paper.Peer ReviewedPostprint (author's final draft

An efficient nonlinear circuit simulation technique

This paper proposes a novel method for the analysis and simulation of integrated circuits (ICs) with the potential to greatly shorten the IC design cycle. The circuits are assumed to be subjected to input signals that have widely separated rates of variation, e.g., in communication systems, an RF carrier modulated by a low-frequency information signal. The proposed technique involves two stages. Initially, a particular order result for the circuit response is obtained using a multiresolution collocation scheme involving cubic spline wavelet decomposition. A more accurate solution is then obtained by adding another layer to the wavelet series approximation. However, the novel technique presented here enables the reuse of results acquired in the first stage to obtain the second-stage result. Therefore, vast gains in efficiency are obtained. Furthermore, a nonlinear model-order reduction technique can readily be used in both stages making the calculations even more efficient. Results will highlight the efficacy of the proposed approac

Shape optimisation with multiresolution subdivision surfaces and immersed finite elements

We develop a new optimisation technique that combines multiresolution subdivision surfaces for boundary description with immersed finite elements for the discretisation of the primal and adjoint problems of optimisation. Similar to wavelets multiresolution surfaces represent the domain boundary using a coarse control mesh and a sequence of detail vectors. Based on the multiresolution decomposition efficient and fast algorithms are available for reconstructing control meshes of varying fineness. During shape optimisation the vertex coordinates of control meshes are updated using the computed shape gradient information. By virtue of the multiresolution editing semantics, updating the coarse control mesh vertex coordinates leads to large-scale geometry changes and, conversely, updating the fine control mesh coordinates leads to small-scale geometry changes. In our computations we start by optimising the coarsest control mesh and refine it each time the cost function reaches a minimum. This approach effectively prevents the appearance of non-physical boundary geometry oscillations and control mesh pathologies, like inverted elements. Independent of the fineness of the control mesh used for optimisation, on the immersed finite element grid the domain boundary is always represented with a relatively fine control mesh of fixed resolution. With the immersed finite element method there is no need to maintain an analysis suitable domain mesh. In some of the presented two- and three-dimensional elasticity examples the topology derivative is used for creating new holes inside the domain.The partial support of the EPSRC through grant # EP/G008531/1 and EC through Marie Curie Actions (IAPP) program CASOPT project are gratefully acknowledged.This is the final version of the article. It was first available from Elsevier via http://dx.doi.org/10.1016/j.cma.2015.11.01

3D Mesh Simplification. A survey of algorithms and CAD model simplification tests

Simplification of highly detailed CAD models is an important step when CAD models are visualized or by other means utilized in augmented reality applications. Without simplification, CAD models may cause severe processing and storage is- sues especially in mobile devices. In addition, simplified models may have other advantages like better visual clarity or improved reliability when used for visual pose tracking. The geometry of CAD models is invariably presented in form of a 3D mesh. In this paper, we survey mesh simplification algorithms in general and focus especially to algorithms that can be used to simplify CAD models. We test some commonly known algorithms with real world CAD data and characterize some new CAD related simplification algorithms that have not been surveyed in previous mesh simplification reviews.Siirretty Doriast

Wavelet representation of functions defined on tetrahedrical grids

In this paper, a method for representing scalar functions on volumes is presented. The method is based on wavelets and it can be used for representing volumetric data (geometric or scalar) defifined on non structured grids. The basic contribution is the extension of wavelets to represent scalar functions on volumetric domains of arbitrary topological type. This extension is made by constructing a wavelet basis defifined on any tetrahedrized volume. This basis construction is achieved using multiresolution analysis and the lifting schemeFacultad de Informátic