848,418 research outputs found

    Numerical loop quantum cosmology: an overview

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    A brief review of various numerical techniques used in loop quantum cosmology and results is presented. These include the way extensive numerical simulations shed insights on the resolution of classical singularities, resulting in the key prediction of the bounce at the Planck scale in different models, and the numerical methods used to analyze the properties of the quantum difference operator and the von Neumann stability issues. Using the quantization of a massless scalar field in an isotropic spacetime as a template, an attempt is made to highlight the complementarity of different methods to gain understanding of the new physics emerging from the quantum theory. Open directions which need to be explored with more refined numerical methods are discussed.Comment: 33 Pages, 4 figures. Invited contribution to appear in Classical and Quantum Gravity special issue on Non-Astrophysical Numerical Relativit

    Theoretical Design and Analysis of Multivolume Digital Assays with Wide Dynamic Range Validated Experimentally with Microfluidic Digital PCR

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    This paper presents a protocol using theoretical methods and free software to design and analyze multivolume digital PCR (MV digital PCR) devices; the theory and software are also applicable to design and analysis of dilution series in digital PCR. MV digital PCR minimizes the total number of wells required for “digital” (single molecule) measurements while maintaining high dynamic range and high resolution. In some examples, multivolume designs with fewer than 200 total wells are predicted to provide dynamic range with 5-fold resolution similar to that of single-volume designs requiring 12 000 wells. Mathematical techniques were utilized and expanded to maximize the information obtained from each experiment and to quantify performance of devices and were experimentally validated using the SlipChip platform. MV digital PCR was demonstrated to perform reliably, and results from wells of different volumes agreed with one another. No artifacts due to different surface-to-volume ratios were observed, and single molecule amplification in volumes ranging from 1 to 125 nL was self-consistent. The device presented here was designed to meet the testing requirements for measuring clinically relevant levels of HIV viral load at the point-of-care (in plasma, 1 000 000 molecules/mL), and the predicted resolution and dynamic range was experimentally validated using a control sequence of DNA. This approach simplifies digital PCR experiments, saves space, and thus enables multiplexing using separate areas for each sample on one chip, and facilitates the development of new high-performance diagnostic tools for resource-limited applications. The theory and software presented here are general and are applicable to designing and analyzing other digital analytical platforms including digital immunoassays and digital bacterial analysis. It is not limited to SlipChip and could also be useful for the design of systems on platforms including valve-based and droplet-based platforms. In a separate publication by Shen et al. (J. Am. Chem. Soc., 2011, DOI: 10.1021/ja2060116), this approach is used to design and test digital RT-PCR devices for quantifying RNA

    SAR image reconstruction by expectation maximization based matching pursuit

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    Cataloged from PDF version of article.Synthetic Aperture Radar (SAR) provides high resolution images of terrain and target reflectivity. SAR systems are indispensable in many remote sensing applications. Phase errors due to uncompensated platform motion degrade resolution in reconstructed images. A multitude of autofocusing techniques has been proposed to estimate and correct phase errors in SAR images. Some autofocus techniques work as a post-processor on reconstructed images and some are integrated into the image reconstruction algorithms. Compressed Sensing (CS), as a relatively new theory, can be applied to sparse SAR image reconstruction especially in detection of strong targets. Autofocus can also be integrated into CS based SAR image reconstruction techniques. However, due to their high computational complexity, CS based techniques are not commonly used in practice. To improve efficiency of image reconstruction we propose a novel CS based SAR imaging technique which utilizes recently proposed Expectation Maximization based Matching Pursuit (EMMP) algorithm. EMMP algorithm is greedy and computationally less complex enabling fast SAR image reconstructions. The proposed EMMP based SAR image reconstruction technique also performs autofocus and image reconstruction simultaneously. Based on a variety of metrics, performance of the proposed EMMP based SAR image reconstruction technique is investigated. The obtained results show that the proposed technique provides high resolution images of sparse target scenes while performing highly accurate motion compensation. (C) 2014 Elsevier Inc. All rights reserved

    Science Goals and Overview of the Radiation Belt Storm Probes (RBSP) Energetic Particle, Composition, and Thermal Plasma (ECT) Suite on NASA’s Van Allen Probes Mission

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    The Radiation Belt Storm Probes (RBSP)-Energetic Particle, Composition, and Thermal Plasma (ECT) suite contains an innovative complement of particle instruments to ensure the highest quality measurements ever made in the inner magnetosphere and radiation belts. The coordinated RBSP-ECT particle measurements, analyzed in combination with fields and waves observations and state-of-the-art theory and modeling, are necessary for understanding the acceleration, global distribution, and variability of radiation belt electrons and ions, key science objectives of NASA’s Living With a Star program and the Van Allen Probes mission. The RBSP-ECT suite consists of three highly-coordinated instruments: the Magnetic Electron Ion Spectrometer (MagEIS), the Helium Oxygen Proton Electron (HOPE) sensor, and the Relativistic Electron Proton Telescope (REPT). Collectively they cover, continuously, the full electron and ion spectra from one eV to 10’s of MeV with sufficient energy resolution, pitch angle coverage and resolution, and with composition measurements in the critical energy range up to 50 keV and also from a few to 50 MeV/nucleon. All three instruments are based on measurement techniques proven in the radiation belts. The instruments use those proven techniques along with innovative new designs, optimized for operation in the most extreme conditions in order to provide unambiguous separation of ions and electrons and clean energy responses even in the presence of extreme penetrating background environments. The design, fabrication and operation of ECT spaceflight instrumentation in the harsh radiation belt environment ensure that particle measurements have the fidelity needed for closure in answering key mission science questions. ECT instrument details are provided in companion papers in this same issue. In this paper, we describe the science objectives of the RBSP-ECT instrument suite on the Van Allen Probe spacecraft within the context of the overall mission objectives, indicate how the characteristics of the instruments satisfy the requirements to achieve these objectives, provide information about science data collection and dissemination, and conclude with a description of some early mission results

    Looking at feet. A neurolinguistic and constraint-based analysis of German word stress

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    In this dissertation, I examine the role of the foot in the assignment of word stress in German in light of results from recent neurolinguistic studies on word stress processing. This relatively new method is used to detect processing effects and support generalizations concerning prosodic structure. In particular, the use of sensitive, (temporally) high-resolution techniques reveals some details that cannot be shown by typological corpus studies alone. A central theme of this dissertation is the utility and even necessity of empirical data, especially from neuro- and psycholinguistic methods, for the development of a sound linguistic theory of phonological structure and processing

    Physics of Solar Prominences: I - Spectral Diagnostics and Non-LTE Modelling

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    This review paper outlines background information and covers recent advances made via the analysis of spectra and images of prominence plasma and the increased sophistication of non-LTE (ie when there is a departure from Local Thermodynamic Equilibrium) radiative transfer models. We first describe the spectral inversion techniques that have been used to infer the plasma parameters important for the general properties of the prominence plasma in both its cool core and the hotter prominence-corona transition region. We also review studies devoted to the observation of bulk motions of the prominence plasma and to the determination of prominence mass. However, a simple inversion of spectroscopic data usually fails when the lines become optically thick at certain wavelengths. Therefore, complex non-LTE models become necessary. We thus present the basics of non-LTE radiative transfer theory and the associated multi-level radiative transfer problems. The main results of one- and two-dimensional models of the prominences and their fine-structures are presented. We then discuss the energy balance in various prominence models. Finally, we outline the outstanding observational and theoretical questions, and the directions for future progress in our understanding of solar prominences.Comment: 96 pages, 37 figures, Space Science Reviews. Some figures may have a better resolution in the published version. New version reflects minor changes brought after proof editin

    Experimental approaches to the difference in the Casimir force through the varying optical properties of boundary surface

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    We propose two novel experiments on the measurement of the Casimir force acting between a gold coated sphere and semiconductor plates with markedly different charge carrier densities. In the first of these experiments a patterned Si plate is used which consists of two sections of different dopant densities and oscillates in the horizontal direction below a sphere. The measurement scheme in this experiment is differential, i.e., allows the direct high-precision measurement of the difference of the Casimir forces between the sphere and sections of the patterned plate or the difference of the equivalent pressures between Au and patterned parallel plates with static and dynamic techniques, respectively. The second experiment proposes to measure the Casimir force between the same sphere and a VO2{}_2 film which undergoes the insulator-metal phase transition with the increase of temperature. We report the present status of the interferometer based variable temperature apparatus developed to perform both experiments and present the first results on the calibration and sensitivity. The magnitudes of the Casimir forces and pressures in the experimental configurations are calculated using different theoretical approaches to the description of optical and conductivity properties of semiconductors at low frequencies proposed in the literature. It is shown that the suggested experiments will aid in the resolution of theoretical problems arising in the application of the Lifshitz theory at nonzero temperature to real materials. They will also open new opportunities in nanotechnology.Comment: 23 pages of the text, 2 tables, and captions of 12 figures (to appear in Phys. Rev. A
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