14,257 research outputs found
Automatic categorization of diverse experimental information in the bioscience literature
Background:
Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM). This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD). We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance.
Results:
We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI). It is being used in the curation work flow at WormBase for automatic association of newly published papers with ten data types including RNAi, antibody, phenotype, gene regulation, mutant allele sequence, gene expression, gene product interaction, overexpression phenotype, gene interaction, and gene structure correction.
Conclusions:
Our methods are applicable to a variety of data types with training set containing several hundreds to a few thousand documents. It is completely automatic and, thus can be readily incorporated to different workflow at different literature-based databases. We believe that the work presented here can contribute greatly to the tremendous task of automating the important yet labor-intensive biocuration effort
Adaptive Graph via Multiple Kernel Learning for Nonnegative Matrix Factorization
Nonnegative Matrix Factorization (NMF) has been continuously evolving in
several areas like pattern recognition and information retrieval methods. It
factorizes a matrix into a product of 2 low-rank non-negative matrices that
will define parts-based, and linear representation of nonnegative data.
Recently, Graph regularized NMF (GrNMF) is proposed to find a compact
representation,which uncovers the hidden semantics and simultaneously respects
the intrinsic geometric structure. In GNMF, an affinity graph is constructed
from the original data space to encode the geometrical information. In this
paper, we propose a novel idea which engages a Multiple Kernel Learning
approach into refining the graph structure that reflects the factorization of
the matrix and the new data space. The GrNMF is improved by utilizing the graph
refined by the kernel learning, and then a novel kernel learning method is
introduced under the GrNMF framework. Our approach shows encouraging results of
the proposed algorithm in comparison to the state-of-the-art clustering
algorithms like NMF, GrNMF, SVD etc.Comment: This paper has been withdrawn by the author due to the terrible
writin
Transforming Graph Representations for Statistical Relational Learning
Relational data representations have become an increasingly important topic
due to the recent proliferation of network datasets (e.g., social, biological,
information networks) and a corresponding increase in the application of
statistical relational learning (SRL) algorithms to these domains. In this
article, we examine a range of representation issues for graph-based relational
data. Since the choice of relational data representation for the nodes, links,
and features can dramatically affect the capabilities of SRL algorithms, we
survey approaches and opportunities for relational representation
transformation designed to improve the performance of these algorithms. This
leads us to introduce an intuitive taxonomy for data representation
transformations in relational domains that incorporates link transformation and
node transformation as symmetric representation tasks. In particular, the
transformation tasks for both nodes and links include (i) predicting their
existence, (ii) predicting their label or type, (iii) estimating their weight
or importance, and (iv) systematically constructing their relevant features. We
motivate our taxonomy through detailed examples and use it to survey and
compare competing approaches for each of these tasks. We also discuss general
conditions for transforming links, nodes, and features. Finally, we highlight
challenges that remain to be addressed
Semi-supervised prediction of protein interaction sentences exploiting semantically encoded metrics
Protein-protein interaction (PPI) identification is an integral component of many biomedical research and database curation tools. Automation of this task through classification is one of the key goals of text mining (TM). However, labelled PPI corpora required to train classifiers are generally small. In order to overcome this sparsity in the training data, we propose a novel method of integrating corpora that do not contain relevance judgements. Our approach uses a semantic language model to gather word similarity from a large unlabelled corpus. This additional information is integrated into the sentence classification process using kernel transformations and has a re-weighting effect on the training features that leads to an 8% improvement in F-score over the baseline results. Furthermore, we discover that some words which are generally considered indicative of interactions are actually neutralised by this process
A Comparative Analysis of Ensemble Classifiers: Case Studies in Genomics
The combination of multiple classifiers using ensemble methods is
increasingly important for making progress in a variety of difficult prediction
problems. We present a comparative analysis of several ensemble methods through
two case studies in genomics, namely the prediction of genetic interactions and
protein functions, to demonstrate their efficacy on real-world datasets and
draw useful conclusions about their behavior. These methods include simple
aggregation, meta-learning, cluster-based meta-learning, and ensemble selection
using heterogeneous classifiers trained on resampled data to improve the
diversity of their predictions. We present a detailed analysis of these methods
across 4 genomics datasets and find the best of these methods offer
statistically significant improvements over the state of the art in their
respective domains. In addition, we establish a novel connection between
ensemble selection and meta-learning, demonstrating how both of these disparate
methods establish a balance between ensemble diversity and performance.Comment: 10 pages, 3 figures, 8 tables, to appear in Proceedings of the 2013
International Conference on Data Minin
Digging into acceptor splice site prediction : an iterative feature selection approach
Feature selection techniques are often used to reduce data dimensionality, increase classification performance, and gain insight into the processes that generated the data. In this paper, we describe an iterative procedure of feature selection and feature construction steps, improving the classification of acceptor splice sites, an important subtask of gene prediction.
We show that acceptor prediction can benefit from feature selection, and describe how feature selection techniques can be used to gain new insights in the classification of acceptor sites. This is illustrated by the identification of a new, biologically motivated feature: the AG-scanning feature.
The results described in this paper contribute both to the domain of gene prediction, and to research in feature selection techniques, describing a new wrapper based feature weighting method that aids in knowledge discovery when dealing with complex datasets
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