Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Hardening DGA classifiers utilizing IVAP

Domain Generation Algorithms (DGAs) are used by malware to generate a deterministic set of domains, usually by utilizing a pseudo-random seed. A malicious botmaster can establish connections between their command-and-control center (C&C) and any malware-infected machines by registering domains that will be DGA-generated given a specific seed, rendering traditional domain blacklisting ineffective. Given the nature of this threat, the real-time detection of DGA domains based on incoming DNS traffic is highly important. The use of neural network machine learning (ML) models for this task has been well-studied, but there is still substantial room for improvement. In this paper, we propose to use Inductive Venn-Abers predictors (IVAPs) to calibrate the output of existing ML models for DGA classification. The IVAP is a computationally efficient procedure which consistently improves the predictive accuracy of classifiers at the expense of not offering predictions for a small subset of inputs and consuming an additional amount of training data

A Comprehensive Survey of Deep Learning in Remote Sensing: Theories, Tools and Challenges for the Community

In recent years, deep learning (DL), a re-branding of neural networks (NNs), has risen to the top in numerous areas, namely computer vision (CV), speech recognition, natural language processing, etc. Whereas remote sensing (RS) possesses a number of unique challenges, primarily related to sensors and applications, inevitably RS draws from many of the same theories as CV; e.g., statistics, fusion, and machine learning, to name a few. This means that the RS community should be aware of, if not at the leading edge of, of advancements like DL. Herein, we provide the most comprehensive survey of state-of-the-art RS DL research. We also review recent new developments in the DL field that can be used in DL for RS. Namely, we focus on theories, tools and challenges for the RS community. Specifically, we focus on unsolved challenges and opportunities as it relates to (i) inadequate data sets, (ii) human-understandable solutions for modelling physical phenomena, (iii) Big Data, (iv) non-traditional heterogeneous data sources, (v) DL architectures and learning algorithms for spectral, spatial and temporal data, (vi) transfer learning, (vii) an improved theoretical understanding of DL systems, (viii) high barriers to entry, and (ix) training and optimizing the DL.Comment: 64 pages, 411 references. To appear in Journal of Applied Remote Sensin

Application of Neural-Like P Systems With State Values for Power Coordination of Photovoltaic/Battery Microgrids

The power coordination control of a photovoltaic/battery microgrid is performed with a novel bio-computing model within the framework of membrane computing. First, a neural-like P system with state values (SVNPS) is proposed for describing complex logical relationships between different modes of Photovoltaic (PV) units and energy storage units. After comparing the objects in the neurons with the thresholds, state values will be obtained to determine the con guration of the SVNPS. Considering the characteristics of PV/battery microgrids, an operation control strategy based on bus voltages of the point of common coupling and charging/discharging statuses of batteries is proposed. At rst, the SVNPS is used to construct the complicated unit working modes; each unit of the microgrid can adjust the operation modes automatically. After that, the output power of each unit is reasonably coordinated to ensure the operation stability of the microgrid. Finally, a PV/battery microgrid, including two PV units, one storage unit, and some loads are taken into consideration, and experimental results show the feasibility and effectiveness of the proposed control strategy and the SVNPS-based power coordination control models