Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Less is More: Micro-expression Recognition from Video using Apex Frame

Despite recent interest and advances in facial micro-expression research, there is still plenty room for improvement in terms of micro-expression recognition. Conventional feature extraction approaches for micro-expression video consider either the whole video sequence or a part of it, for representation. However, with the high-speed video capture of micro-expressions (100-200 fps), are all frames necessary to provide a sufficiently meaningful representation? Is the luxury of data a bane to accurate recognition? A novel proposition is presented in this paper, whereby we utilize only two images per video: the apex frame and the onset frame. The apex frame of a video contains the highest intensity of expression changes among all frames, while the onset is the perfect choice of a reference frame with neutral expression. A new feature extractor, Bi-Weighted Oriented Optical Flow (Bi-WOOF) is proposed to encode essential expressiveness of the apex frame. We evaluated the proposed method on five micro-expression databases: CAS(ME)$^2$, CASME II, SMIC-HS, SMIC-NIR and SMIC-VIS. Our experiments lend credence to our hypothesis, with our proposed technique achieving a state-of-the-art F1-score recognition performance of 61% and 62% in the high frame rate CASME II and SMIC-HS databases respectively.Comment: 14 pages double-column, author affiliations updated, acknowledgment of grant support adde