Modeling Fault Propagation Paths in Power Systems: A New Framework Based on Event SNP Systems With Neurotransmitter Concentration

To reveal fault propagation paths is one of the most critical studies for the analysis of power system security; however, it is rather dif cult. This paper proposes a new framework for the fault propagation path modeling method of power systems based on membrane computing.We rst model the fault propagation paths by proposing the event spiking neural P systems (Ev-SNP systems) with neurotransmitter concentration, which can intuitively reveal the fault propagation path due to the ability of its graphics models and parallel knowledge reasoning. The neurotransmitter concentration is used to represent the probability and gravity degree of fault propagation among synapses. Then, to reduce the dimension of the Ev-SNP system and make them suitable for large-scale power systems, we propose a model reduction method for the Ev-SNP system and devise its simpli ed model by constructing single-input and single-output neurons, called reduction-SNP system (RSNP system). Moreover, we apply the RSNP system to the IEEE 14- and 118-bus systems to study their fault propagation paths. The proposed approach rst extends the SNP systems to a large-scaled application in critical infrastructures from a single element to a system-wise investigation as well as from the post-ante fault diagnosis to a new ex-ante fault propagation path prediction, and the simulation results show a new success and promising approach to the engineering domain

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

A numerical model for Hodgkin-Huxley neural stimulus reconstruction

The information about a neural activity is encoded in a neural response and usually the underlying stimulus that triggers the activity is unknown. This paper presents a numerical solution to reconstruct stimuli from Hodgkin-Huxley neural responses while retrieving the neural dynamics. The stimulus is reconstructed by first retrieving the maximal conductances of the ion channels and then solving the Hodgkin-Huxley equations for the stimulus. The results show that the reconstructed stimulus is a good approximation of the original stimulus, while the retrieved the neural dynamics, which represent the voltage-dependent changes in the ion channels, help to understand the changes in neural biochemistry. As high non-linearity of neural dynamics renders analytical inversion of a neuron an arduous task, a numerical approach provides a local solution to the problem of stimulus reconstruction and neural dynamics retrieval