Psychobiological factors of resilience and depression in late life.

In contrast to traditional perspectives of resilience as a stable, trait-like characteristic, resilience is now recognized as a multidimentional, dynamic capacity influenced by life-long interactions between internal and environmental resources. We review psychosocial and neurobiological factors associated with resilience to late-life depression (LLD). Recent research has identified both psychosocial characteristics associated with elevated LLD risk (e.g., insecure attachment, neuroticism) and psychosocial processes that may be useful intervention targets (e.g., self-efficacy, sense of purpose, coping behaviors, social support). Psychobiological factors include a variety of endocrine, genetic, inflammatory, metabolic, neural, and cardiovascular processes that bidirectionally interact to affect risk for LLD onset and course of illness. Several resilience-enhancing intervention modalities show promise for the prevention and treatment of LLD, including cognitive/psychological or mind-body (positive psychology; psychotherapy; heart rate variability biofeedback; meditation), movement-based (aerobic exercise; yoga; tai chi), and biological approaches (pharmacotherapy, electroconvulsive therapy). Additional research is needed to further elucidate psychosocial and biological factors that affect risk and course of LLD. In addition, research to identify psychobiological factors predicting differential treatment response to various interventions will be essential to the development of more individualized and effective approaches to the prevention and treatment of LLD

Differences in well-being:the biological and environmental causes, related phenotypes, and real-time assessment

Well-being is a complex, and multifaceted construct that includes feeling good and functioning well. There is a growing global recognition of well-being as an important research topic and public policy goal. Well-being is related to less behavioral and emotional problems, and is associated with many positive aspects of daily life, including longevity, higher educational achievement, happier marriage, and more productivity at work. People differ in their levels of well-being, i.e., some people are in general happier or more satisfied with their lives than others. These individual differences in well-being can arise from many different factors, including biological (genetic) influences and environmental influences. To enhance the development of future mental health prevention and intervention strategies to increase well-being, more knowledge about these determinants and factors underlying well-being is needed. In this dissertation, I aimed to increase the understanding of the etiology in a series of studies using different methods, including systematic reviews, meta-analyses, twin designs, and molecular genetic designs. In part I, we brought together all published studies on the neural and physiological factors underlying well-being. This overview allowed us to critically investigate the claims made about the biology involved in well-being. The number of studies on the neural and physiological factors underlying well-being is increasing and the results point towards potential correlates of well-being. However, samples are often still small, and studies focus mostly on a single biomarker. Therefore, more well-powered, data-driven, and integrative studies across biological categories are needed to better understand the neural and physiological pathways that play a role in well-being. In part II, we investigated the overlap between well-being and a range of other phenotypes to learn more about the etiology of well-being. We report a large overlap with phenotypes including optimism, resilience, and depressive symptoms. Furthermore, when removing the genetic overlap between well-being and depressive symptoms, we showed that well-being has unique genetic associations with a range of phenotypes, independently from depressive symptoms. These results can be helpful in designing more effective interventions to increase well-being, taking into account the overlap and possible causality with other phenotypes. In part III, we used the extreme environmental change during the COVID-19 pandemic to investigate individual differences in the effects of such environmental changes on well-being. On average, we found a negative effect of the pandemic on different aspects of well-being, especially further into the pandemic. Whereas most previous studies only looked at this average negative effect of the pandemic on well-being, we focused on the individual differences as well. We reported large individual differences in the effects of the pandemic on well-being in both chapters. This indicates that one-size-fits-all preventions or interventions to maintain or increase well-being during the pandemic or lockdowns will not be successful for the whole population. Further research is needed for the identification of protective factors and resilience mechanisms to prevent further inequality during extreme environmental situations. In part IV, we looked at the real-time assessment of well-being, investigating the feasibility and results of previous studies. The real-time assessment of well-being, related variables, and the environment can lead to new insights about well-being, i.e., results that we cannot capture with traditional survey research. The real-time assessment of well-being is therefore a promising area for future research to unravel the dynamic nature of well-being fluctuations and the interaction with the environment in daily life. Integrating all results in this dissertation confirmed that well-being is a complex human trait that is influenced by many interrelated and interacting factors. Future directions to understand individual differences in well-being will be a data-driven approach to investigate the complex interplay of neural, physiological, genetic, and environmental factors in well-being

Modeling the Causal Relationship Between Parental Treatment Methods, Psychological Resilience and Life- Satisfaction

This study aimed at modeling the causal relationship between parental treatment methods, psychological resilience and life- satisfaction among the university youth in Kuwait and Saudi Arabia, to answer the aim of the study, the analytical survey method was used, the two researchers used the questionnaire as a study tool. The Research population consisted of all University Youth in Kuwait and Saudi Arabia, for the academic year (2016/2017), and the study sample consisted of (1009) individuals who were chosen randomly, the study findings showed that The psychological resilience mediates the relationship between parental treatment methods (by father) and satisfaction with life. And psychological resilience mediates the relationship between parental treatment methods (by mother) and Life- Satisfaction

The interaction of risk and protective factors for mental disorders on psychopathology and brain morphometry

As per the diathesis-stress model, combined early risk factors (diathesis) and current risk factors (stress) determine an individual’s likelihood for the development of psychopathology. If the combined impact of diathesis and stress surpasses a certain threshold, individuals will develop psychopathology. At the same time, such threshold could be raised in the presence of protective factors, as they buffer the negative impact of risk factors, and lead to a reduced likelihood of developing psychopathology. Early risk factors for mental disorders include trait anxiety, childhood maltreatment and familial risk, and have been associated with specific brain morphometric alterations. Stressful life events, including the Covid-19 pandemic as a global example of that, constitute current risk factors. On the other hand, current literature suggests social support and conscientiousness as exemplary protective factors. These may increase resilience, a concept describing an individual’s ability to adaptively cope in the face of adversity and maintain mental health. However, contrary to risk factors, neural correlates of resilience are only sparsely known and hardly understood. Thus, to make precise predictions about the emergence of psychopathology in certain circumstances and understand possible neurobiological pathways, it is essential to jointly consider both risk and protective factors in mental health research. The aim of this dissertation was to investigate the interaction of risk and protective factors in three different but complementary contexts to gain a deeper understanding of these factors and their impact on brain morphometry and psychopathology. In STUDY I, morphometric correlates (specifically grey matter volume) of resilience were investigated. In this study, resilience was conceptualized as the maintenance of mental health despite a high risk (i.e., childhood maltreatment and familial risk). A key finding is that healthy high-risk individuals demonstrated larger grey matter volume in the left dorsolateral prefrontal cortex, an area associated with cognitive flexibility and emotional regulation skills, compared to the other groups. It seems plausible that an increased volume in this area is a neural correlate of resilience to high risk and may represent compensatory processes aiding high-risk individuals in maintaining mental health. STUDY II approached the subject in the opposite way, with transdiagnostic grey matter volume alterations in psychiatric patients compared to healthy subjects being associated with risk and protective factors. This study identified reduced volume in the left hippocampus as a transdiagnostic vulnerability marker in patients with major depression, bipolar disorder, and schizophrenia spectrum disorder. Volume in this area was further negatively associated with stressful life events, and executive and global functioning in both patients and healthy subjects. We conclude that stressful life events likely constitute a dimensional risk factor for reduced hippocampal volume and, therefore, are independent of diagnosis. STUDY III investigated the impact of a unique, acute global stressor, the Covid-19 pandemic, on healthy subjects and transdiagnostic patients. Multiple trait risk and protective factors were tested for their explanatory value of current Covid-19-related fear and isolation. This study identified trait anxiety and conscientiousness as risk factors for increased Covid-19-related fear, and social support as a protective factor against increased Covid-19-isolation. Again, the respective effect (harmful or protective) of all these factors was dimensional, i.e., relevant in both psychiatric patients and healthy subjects. STUDY III also highlighted the context-dependency of risk and protective factors: although generally considered a protective trait, increased conscientiousness was harmful in the context of a global pandemic due to the immense level of uncertainty and unpredictability. In conclusion, this dissertation identified brain correlates as potential biomarkers of psychopathology and resilience, and procedural contributors to adaptive and maladaptive responses to acute stressors. It highlighted the importance of taking protective factors, in addition to risk factors, into account in research. A major strength is the integration of multiple risk and protective factors, as such integrative approaches are crucial to advance the understanding of their complex interplay. By identifying dimensionality and context-dependency as important modulatory influences in the risk and protective factor interplay, it provided a framework for a more comprehensive understanding of the development of psychopathology, and the concept of resilience as a dynamic, continuous process of adaptation to changing environments, which enables individuals to maintain mental health even in the face of adversity

Eye quietness and quiet eye in expert and novice golf performance: an electrooculographic analysis

Quiet eye (QE) is the final ocular fixation on the target of an action (e.g., the ball in golf putting). Camerabased eye-tracking studies have consistently found longer QE durations in experts than novices; however, mechanisms underlying QE are not known. To offer a new perspective we examined the feasibility of measuring the QE using electrooculography (EOG) and developed an index to assess ocular activity across time: eye quietness (EQ). Ten expert and ten novice golfers putted 60 balls to a 2.4 m distant hole. Horizontal EOG (2ms resolution) was recorded from two electrodes placed on the outer sides of the eyes. QE duration was measured using a EOG voltage threshold and comprised the sum of the pre-movement and post-movement initiation components. EQ was computed as the standard deviation of the EOG in 0.5 s bins from –4 to +2 s, relative to backswing initiation: lower values indicate less movement of the eyes, hence greater quietness. Finally, we measured club-ball address and swing durations. T-tests showed that total QE did not differ between groups (p = .31); however, experts had marginally shorter pre-movement QE (p = .08) and longer post-movement QE (p < .001) than novices. A group × time ANOVA revealed that experts had less EQ before backswing initiation and greater EQ after backswing initiation (p = .002). QE durations were inversely correlated with EQ from –1.5 to 1 s (rs = –.48 - –.90, ps = .03 - .001). Experts had longer swing durations than novices (p = .01) and, importantly, swing durations correlated positively with post-movement QE (r = .52, p = .02) and negatively with EQ from 0.5 to 1s (r = –.63, p = .003). This study demonstrates the feasibility of measuring ocular activity using EOG and validates EQ as an index of ocular activity. Its findings challenge the dominant perspective on QE and provide new evidence that expert-novice differences in ocular activity may reflect differences in the kinematics of how experts and novices execute skills

Dissociation and interpersonal autonomic physiology in psychotherapy research: an integrative view encompassing psychodynamic and neuroscience theoretical frameworks

Interpersonal autonomic physiology is an interdisciplinary research field, assessing the relational interdependence of two (or more) interacting individual both at the behavioral and psychophysiological levels. Despite its quite long tradition, only eight studies since 1955 have focused on the interaction of psychotherapy dyads, and none of them have focused on the shared processual level, assessing dynamic phenomena such as dissociation. We longitudinally observed two brief psychodynamic psychotherapies, entirely audio and video-recorded (16 sessions, weekly frequency, 45 min.). Autonomic nervous system measures were continuously collected during each session. Personality, empathy, dissociative features and clinical progress measures were collected prior and post therapy, and after each clinical session. Two-independent judges, trained psychotherapist, codified the interactions\u2019 micro-processes. Time-series based analyses were performed to assess interpersonal synchronization and de-synchronization in patient\u2019s and therapist\u2019s physiological activity. Psychophysiological synchrony revealed a clear association with empathic attunement, while desynchronization phases (range of length 30-150 sec.) showed a linkage with dissociative processes, usually associated to the patient\u2019s narrative core relational trauma. Our findings are discussed under the perspective of psychodynamic models of Stern (\u201cpresent moment\u201d), Sander, Beebe and Lachmann (dyad system model of interaction), Lanius (Trauma model), and the neuroscientific frameworks proposed by Thayer (neurovisceral integration model), and Porges (polyvagal theory). The collected data allows to attempt an integration of these theoretical approaches under the light of Complex Dynamic Systems. The rich theoretical work and the encouraging clinical results might represents a new fascinating frontier of research in psychotherapy