Homogeneous and Scalable Gene Expression Regulatory Networks with Random Layouts of Switching Parameters

We consider a model of large regulatory gene expression networks where the thresholds activating the sigmoidal interactions between genes and the signs of these interactions are shuffled randomly. Such an approach allows for a qualitative understanding of network dynamics in a lack of empirical data concerning the large genomes of living organisms. Local dynamics of network nodes exhibits the multistationarity and oscillations and depends crucially upon the global topology of a "maximal" graph (comprising of all possible interactions between genes in the network). The long time behavior observed in the network defined on the homogeneous "maximal" graphs is featured by the fraction of positive interactions ($0\leq \eta\leq 1$) allowed between genes. There exists a critical value $\eta_c<1$ such that if $\eta<\eta_c$, the oscillations persist in the system, otherwise, when $\eta>\eta_c,$ it tends to a fixed point (which position in the phase space is determined by the initial conditions and the certain layout of switching parameters). In networks defined on the inhomogeneous directed graphs depleted in cycles, no oscillations arise in the system even if the negative interactions in between genes present therein in abundance ($\eta_c=0$). For such networks, the bidirectional edges (if occur) influence on the dynamics essentially. In particular, if a number of edges in the "maximal" graph is bidirectional, oscillations can arise and persist in the system at any low rate of negative interactions between genes ($\eta_c=1$). Local dynamics observed in the inhomogeneous scalable regulatory networks is less sensitive to the choice of initial conditions. The scale free networks demonstrate their high error tolerance.Comment: LaTeX, 30 pages, 20 picture

SketchyGAN: Towards Diverse and Realistic Sketch to Image Synthesis

Synthesizing realistic images from human drawn sketches is a challenging problem in computer graphics and vision. Existing approaches either need exact edge maps, or rely on retrieval of existing photographs. In this work, we propose a novel Generative Adversarial Network (GAN) approach that synthesizes plausible images from 50 categories including motorcycles, horses and couches. We demonstrate a data augmentation technique for sketches which is fully automatic, and we show that the augmented data is helpful to our task. We introduce a new network building block suitable for both the generator and discriminator which improves the information flow by injecting the input image at multiple scales. Compared to state-of-the-art image translation methods, our approach generates more realistic images and achieves significantly higher Inception Scores.Comment: Accepted to CVPR 201

FaceShop: Deep Sketch-based Face Image Editing

We present a novel system for sketch-based face image editing, enabling users to edit images intuitively by sketching a few strokes on a region of interest. Our interface features tools to express a desired image manipulation by providing both geometry and color constraints as user-drawn strokes. As an alternative to the direct user input, our proposed system naturally supports a copy-paste mode, which allows users to edit a given image region by using parts of another exemplar image without the need of hand-drawn sketching at all. The proposed interface runs in real-time and facilitates an interactive and iterative workflow to quickly express the intended edits. Our system is based on a novel sketch domain and a convolutional neural network trained end-to-end to automatically learn to render image regions corresponding to the input strokes. To achieve high quality and semantically consistent results we train our neural network on two simultaneous tasks, namely image completion and image translation. To the best of our knowledge, we are the first to combine these two tasks in a unified framework for interactive image editing. Our results show that the proposed sketch domain, network architecture, and training procedure generalize well to real user input and enable high quality synthesis results without additional post-processing.Comment: 13 pages, 20 figure

Synthesis of linear quantum stochastic systems via quantum feedback networks

Recent theoretical and experimental investigations of coherent feedback control, the feedback control of a quantum system with another quantum system, has raised the important problem of how to synthesize a class of quantum systems, called the class of linear quantum stochastic systems, from basic quantum optical components and devices in a systematic way. The synthesis theory sought in this case can be naturally viewed as a quantum analogue of linear electrical network synthesis theory and as such has potential for applications beyond the realization of coherent feedback controllers. In earlier work, Nurdin, James and Doherty have established that an arbitrary linear quantum stochastic system can be realized as a cascade connection of simpler one degree of freedom quantum harmonic oscillators, together with a direct interaction Hamiltonian which is bilinear in the canonical operators of the oscillators. However, from an experimental perspective and based on current methods and technologies, direct interaction Hamiltonians are challenging to implement for systems with more than just a few degrees of freedom. In order to facilitate more tractable physical realizations of these systems, this paper develops a new synthesis algorithm for linear quantum stochastic systems that relies solely on field-mediated interactions, including in implementation of the direct interaction Hamiltonian. Explicit synthesis examples are provided to illustrate the realization of two degrees of freedom linear quantum stochastic systems using the new algorithm.Comment: 21 pages, 6 figure

The Synthesis of Cyclic Combinatorial Circuits

To be added

Synthesis of Stochastic Flow Networks

A stochastic flow network is a directed graph with incoming edges (inputs) and outgoing edges (outputs), tokens enter through the input edges, travel stochastically in the network, and can exit the network through the output edges. Each node in the network is a splitter, namely, a token can enter a node through an incoming edge and exit on one of the output edges according to a predefined probability distribution. Stochastic flow networks can be easily implemented by DNA-based chemical reactions, with promising applications in molecular computing and stochastic computing. In this paper, we address a fundamental synthesis question: Given a finite set of possible splitters and an arbitrary rational probability distribution, design a stochastic flow network, such that every token that enters the input edge will exit the outputs with the prescribed probability distribution. The problem of probability transformation dates back to von Neumann's 1951 work and was followed, among others, by Knuth and Yao in 1976. Most existing works have been focusing on the "simulation" of target distributions. In this paper, we design optimal-sized stochastic flow networks for "synthesizing" target distributions. It shows that when each splitter has two outgoing edges and is unbiased, an arbitrary rational probability \frac{a}{b} with a\leq b\leq 2^n can be realized by a stochastic flow network of size n that is optimal. Compared to the other stochastic systems, feedback (cycles in networks) strongly improves the expressibility of stochastic flow networks.Comment: 2 columns, 15 page