Evaluation of real-world mobility in age-related macular degeneration.

BACKGROUND: Previous research has suggested an association between poor vision and decreased mobility, including restricted levels of physical activity and travel away from home. We sought to determine the impact of age-related macular degeneration (AMD) on these measures of mobility. METHODS: Fifty-seven AMD patients with bilateral, or severe unilateral, visual impairment were compared to 59 controls with normal vision. All study subjects were between the ages of 60 and 80. Subjects wore accelerometers and cellular network-based tracking devices over 7 days of normal activity. Number of steps taken, time spent in moderate-to-vigorous physical activity (MVPA), number of excursions from home, and time spent away from home were the primary outcome measures. RESULTS: In multivariate negative binomial regression models adjusted for age, gender, race, comorbidities, and education, AMD participants took fewer steps than controls (18% fewer steps per day, p = 0.01) and spent significantly less time in MVPA (35% fewer minutes, p \u3c 0.001). In multivariate logistic regression models adjusting for age, sex, race, cognition, comorbidities, and grip strength, AMD subjects showed an increased likelihood of not leaving their home on a given day (odds ratio = 1.36, p = 0.04), but did not show a significant difference in the magnitude of time spent away from home (9% fewer minutes, p = 0.11). CONCLUSION: AMD patients with poorer vision engage in significantly less physical activity and take fewer excursions away from the home. Further studies identifying the factors mediating the relationship between vision loss and mobility are needed to better understand how to improve mobility among AMD patients

Calling in sick: Impacts of fever on intra-urban human mobility

© 2016 The Author(s) Published by the Royal Society. All rights reserved. Pathogens inflict a wide variety of disease manifestations on their hosts, yet the impacts of disease on the behaviour of infected hosts are rarely studied empirically and are seldom accounted for in mathematical models of transmission dynamics. We explored the potential impacts of one of the most common disease manifestations, fever, on a key determinant of pathogen transmission, host mobility, in residents of the Amazonian city of Iquitos, Peru. We did so by comparing two groups of febrile individuals (dengue-positive and dengue-negative) with an afebrile control group. A retrospective, semi-structured interview allowed us to quantify multiple aspects of mobility during the two-week period preceding each interview. We fitted nested models of each aspect of mobility to data from interviews and compared models using likelihood ratio tests to determine whether there were statistically distinguishable differences in mobility attributable to fever or its aetiology. Compared with afebrile individuals, febrile study participants spent more time at home, visited fewer locations, and, in some cases, visited locations closer to home and spent less time at certain types of locations. These multifaceted impacts are consistent with the possibility that disease-mediated changes in host mobility generate dynamic and complex changes in host contact network structure

A Comparison of Spatial-based Targeted Disease Containment Strategies using Mobile Phone Data

Epidemic outbreaks are an important healthcare challenge, especially in developing countries where they represent one of the major causes of mortality. Approaches that can rapidly target subpopulations for surveillance and control are critical for enhancing containment processes during epidemics. Using a real-world dataset from Ivory Coast, this work presents an attempt to unveil the socio-geographical heterogeneity of disease transmission dynamics. By employing a spatially explicit meta-population epidemic model derived from mobile phone Call Detail Records (CDRs), we investigate how the differences in mobility patterns may affect the course of a realistic infectious disease outbreak. We consider different existing measures of the spatial dimension of human mobility and interactions, and we analyse their relevance in identifying the highest risk sub-population of individuals, as the best candidates for isolation countermeasures. The approaches presented in this paper provide further evidence that mobile phone data can be effectively exploited to facilitate our understanding of individuals' spatial behaviour and its relationship with the risk of infectious diseases' contagion. In particular, we show that CDRs-based indicators of individuals' spatial activities and interactions hold promise for gaining insight of contagion heterogeneity and thus for developing containment strategies to support decision-making during country-level pandemics

Prediction of mobility entropy in an ambient intelligent environment

Ambient Intelligent (AmI) technology can be used to help older adults to live longer and independent lives in their own homes. Information collected from AmI environment can be used to detect and understanding human behaviour, allowing personalized care. The behaviour pattern can also be used to detect changes in behaviour and predict future trends, so that preventive action can be taken. However, due to the large number of sensors in the environment, sensor data are often complex and difficult to interpret, especially to capture behaviour trends and to detect changes over the long-term. In this paper, a model to predict the indoor mobility using binary sensors is proposed. The model utilizes weekly routine to predict the future trend. The proposed method is validated using data collected from a real home environment, and the results show that using weekly pattern helps improve indoor mobility prediction. Also, a new measurement, Mobility Entropy (ME), to measure indoor mobility based on entropy concept is proposed. The results indicate ME can be used to distinguish elders with different mobility and to see decline in mobility. The proposed work would allow detection of changes in mobility, and to foresee the future mobility trend if the current behaviour continues

A survey on Human Mobility and its applications

Human Mobility has attracted attentions from different fields of studies such as epidemic modeling, traffic engineering, traffic prediction and urban planning. In this survey we review major characteristics of human mobility studies including from trajectory-based studies to studies using graph and network theory. In trajectory-based studies statistical measures such as jump length distribution and radius of gyration are analyzed in order to investigate how people move in their daily life, and if it is possible to model this individual movements and make prediction based on them. Using graph in mobility studies, helps to investigate the dynamic behavior of the system, such as diffusion and flow in the network and makes it easier to estimate how much one part of the network influences another by using metrics like centrality measures. We aim to study population flow in transportation networks using mobility data to derive models and patterns, and to develop new applications in predicting phenomena such as congestion. Human Mobility studies with the new generation of mobility data provided by cellular phone networks, arise new challenges such as data storing, data representation, data analysis and computation complexity. A comparative review of different data types used in current tools and applications of Human Mobility studies leads us to new approaches for dealing with mentioned challenges