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Performance Comparison of Knowledge-Based Dose Prediction Techniques Based on Limited Patient Data.
PurposeThe accuracy of dose prediction is essential for knowledge-based planning and automated planning techniques. We compare the dose prediction accuracy of 3 prediction methods including statistical voxel dose learning, spectral regression, and support vector regression based on limited patient training data.MethodsStatistical voxel dose learning, spectral regression, and support vector regression were used to predict the dose of noncoplanar intensity-modulated radiation therapy (4π) and volumetric-modulated arc therapy head and neck, 4π lung, and volumetric-modulated arc therapy prostate plans. Twenty cases of each site were used for k-fold cross-validation, with k = 4. Statistical voxel dose learning bins voxels according to their Euclidean distance to the planning target volume and uses the median to predict the dose of new voxels. Distance to the planning target volume, polynomial combinations of the distance components, planning target volume, and organ at risk volume were used as features for spectral regression and support vector regression. A total of 28 features were included. Principal component analysis was performed on the input features to test the effect of dimension reduction. For the coplanar volumetric-modulated arc therapy plans, separate models were trained for voxels within the same axial slice as planning target volume voxels and voxels outside the primary beam. The effect of training separate models for each organ at risk compared to all voxels collectively was also tested. The mean squared error was calculated to evaluate the voxel dose prediction accuracy.ResultsStatistical voxel dose learning using separate models for each organ at risk had the lowest root mean squared error for all sites and modalities: 3.91 Gy (head and neck 4π), 3.21 Gy (head and neck volumetric-modulated arc therapy), 2.49 Gy (lung 4π), and 2.35 Gy (prostate volumetric-modulated arc therapy). Compared to using the original features, principal component analysis reduced the 4π prediction error for head and neck spectral regression (-43.9%) and support vector regression (-42.8%) and lung support vector regression (-24.4%) predictions. Principal component analysis was more effective in using all/most of the possible principal components. Separate organ at risk models were more accurate than training on all organ at risk voxels in all cases.ConclusionCompared with more sophisticated parametric machine learning methods with dimension reduction, statistical voxel dose learning is more robust to patient variability and provides the most accurate dose prediction method
Graph Signal Processing: Overview, Challenges and Applications
Research in Graph Signal Processing (GSP) aims to develop tools for
processing data defined on irregular graph domains. In this paper we first
provide an overview of core ideas in GSP and their connection to conventional
digital signal processing. We then summarize recent developments in developing
basic GSP tools, including methods for sampling, filtering or graph learning.
Next, we review progress in several application areas using GSP, including
processing and analysis of sensor network data, biological data, and
applications to image processing and machine learning. We finish by providing a
brief historical perspective to highlight how concepts recently developed in
GSP build on top of prior research in other areas.Comment: To appear, Proceedings of the IEE
Shape: A 3D Modeling Tool for Astrophysics
We present a flexible interactive 3D morpho-kinematical modeling application
for astrophysics. Compared to other systems, our application reduces the
restrictions on the physical assumptions, data type and amount that is required
for a reconstruction of an object's morphology. It is one of the first publicly
available tools to apply interactive graphics to astrophysical modeling. The
tool allows astrophysicists to provide a-priori knowledge about the object by
interactively defining 3D structural elements. By direct comparison of model
prediction with observational data, model parameters can then be automatically
optimized to fit the observation. The tool has already been successfully used
in a number of astrophysical research projects.Comment: 13 pages, 11 figures, accepted for publication in the "IEEE
Transactions on Visualization and Computer Graphics
A Neural Model of Visually Guided Steering, Obstacle Avoidance, and Route Selection
A neural model is developed to explain how humans can approach a goal object on foot while steering around obstacles to avoid collisions in a cluttered environment. The model uses optic flow from a 3D virtual reality environment to determine the position of objects based on motion discontinuities, and computes heading direction, or the direction of self-motion, from global optic flow. The cortical representation of heading interacts with the representations of a goal and obstacles such that the goal acts as an attractor of heading, while obstacles act as repellers. In addition the model maintains fixation on the goal object by generating smooth pursuit eye movements. Eye rotations can distort the optic flow field, complicating heading perception, and the model uses extraretinal signals to correct for this distortion and accurately represent heading. The model explains how motion processing mechanisms in cortical areas MT, MST, and posterior parietal cortex can be used to guide steering. The model quantitatively simulates human psychophysical data about visually-guided steering, obstacle avoidance, and route selection.Air Force Office of Scientific Research (F4960-01-1-0397); National Geospatial-Intelligence Agency (NMA201-01-1-2016); National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624
A Neural Model of Visually Guided Steering, Obstacle Avoidance, and Route Selection
A neural model is developed to explain how humans can approach a goal object on foot while steering around obstacles to avoid collisions in a cluttered environment. The model uses optic flow from a 3D virtual reality environment to determine the position of objects based on motion discotinuities, and computes heading direction, or the direction of self-motion, from global optic flow. The cortical representation of heading interacts with the representations of a goal and obstacles such that the goal acts as an attractor of heading, while obstacles act as repellers. In addition the model maintains fixation on the goal object by generating smooth pursuit eye movements. Eye rotations can distort the optic flow field, complicating heading perception, and the model uses extraretinal signals to correct for this distortion and accurately represent heading. The model explains how motion processing mechanisms in cortical areas MT, MST, and VIP can be used to guide steering. The model quantitatively simulates human psychophysical data about visually-guided steering, obstacle avoidance, and route selection.Air Force Office of Scientific Research (F4960-01-1-0397); National Geospatial-Intelligence Agency (NMA201-01-1-2016); National Science Foundation (NSF SBE-0354378); Office of Naval Research (N00014-01-1-0624
3D Shape Segmentation with Projective Convolutional Networks
This paper introduces a deep architecture for segmenting 3D objects into
their labeled semantic parts. Our architecture combines image-based Fully
Convolutional Networks (FCNs) and surface-based Conditional Random Fields
(CRFs) to yield coherent segmentations of 3D shapes. The image-based FCNs are
used for efficient view-based reasoning about 3D object parts. Through a
special projection layer, FCN outputs are effectively aggregated across
multiple views and scales, then are projected onto the 3D object surfaces.
Finally, a surface-based CRF combines the projected outputs with geometric
consistency cues to yield coherent segmentations. The whole architecture
(multi-view FCNs and CRF) is trained end-to-end. Our approach significantly
outperforms the existing state-of-the-art methods in the currently largest
segmentation benchmark (ShapeNet). Finally, we demonstrate promising
segmentation results on noisy 3D shapes acquired from consumer-grade depth
cameras.Comment: This is an updated version of our CVPR 2017 paper. We incorporated
new experiments that demonstrate ShapePFCN performance under the case of
consistent *upright* orientation and an additional input channel in our
rendered images for encoding height from the ground plane (upright axis
coordinate values). Performance is improved in this settin
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