DNA-Based Kinship Analysis

Relatedness between individuals and groups can be investigated using DNA markers. A child’s DNA profile is a combination of alleles passed down from the father and mother. This means that relationships can be investigated between alleged family members. DNA profiling is commonly used to test for potential paternity, parentage and sibship (whether people are related as brothers or sisters) relationships. In many forensic cases more complex relationships have to be considered

Achieving the Millennium Development Goal of reducing maternal mortality in rural Africa: an experience from Burundi.

OBJECTIVES: To estimate the reduction in maternal mortality associated with the emergency obstetric care provided by Médecins Sans Frontières (MSF) and to compare this to the fifth Millennium Development Goal of reducing maternal mortality. METHODS: The impact of MSF's intervention was approximated by estimating how many deaths were averted among women transferred to and treated at MSF's emergency obstetric care facility in Kabezi, Burundi, with a severe acute maternal morbidity. Using this estimate, the resulting theoretical maternal mortality ratio in Kabezi was calculated and compared to the Millennium Development Goal for Burundi. RESULTS: In 2011, 1385 women from Kabezi were transferred to the MSF facility, of whom 55% had a severe acute maternal morbidity. We estimated that the MSF intervention averted 74% (range 55-99%) of maternal deaths in Kabezi district, equating to a district maternal mortality rate of 208 (range 8-360) deaths/100 000 live births. This lies very near to the 2015 MDG 5 target for Burundi (285 deaths/100 000 live births). CONCLUSION: Provision of quality emergency obstetric care combined with a functional patient transfer system can be associated with a rapid and substantial reduction in maternal mortality, and may thus be a possible way to achieve Millennium Development Goal 5 in rural Africa

An Extended Stable Marriage Problem Algorithm for Clone Detection

Code cloning negatively affects industrial software and threatens intellectual property. This paper presents a novel approach to detecting cloned software by using a bijective matching technique. The proposed approach focuses on increasing the range of similarity measures and thus enhancing the precision of the detection. This is achieved by extending a well-known stable-marriage problem (SMP) and demonstrating how matches between code fragments of different files can be expressed. A prototype of the proposed approach is provided using a proper scenario, which shows a noticeable improvement in several features of clone detection such as scalability and accuracy.Comment: 20 pages, 10 figures, 6 table

Monitoring and analysis of data from complex systems

Some of the methods, systems, and prototypes that have been tested for monitoring and analyzing the data from several spacecraft and vehicles at the Marshall Space Flight Center are introduced. For the Huntsville Operations Support Center (HOSC) infrastructure, the Marshall Integrated Support System (MISS) provides a migration path to the state-of-the-art workstation environment. Its modular design makes it possible to implement the system in stages on multiple platforms without the need for all components to be in place at once. The MISS provides a flexible, user-friendly environment for monitoring and controlling orbital payloads. In addition, new capabilities and technology may be incorporated into MISS with greater ease. The use of information systems technology in advanced prototype phases, as adjuncts to mainline activities, is used to evaluate new computational techniques for monitoring and analysis of complex systems. Much of the software described (specially, HSTORESIS (Hubble Space Telescope Operational Readiness Expert Safemode Investigation System), DRS (Device Reasoning Shell), DART (Design Alternatives Rational Tool), elements of the DRA (Document Retrieval Assistant), and software for the PPS (Peripheral Processing System) and the HSPP (High-Speed Peripheral Processor)) is available with supporting documentation, and may be applicable to other system monitoring and analysis applications

Datacenter Traffic Control: Understanding Techniques and Trade-offs

Datacenters provide cost-effective and flexible access to scalable compute and storage resources necessary for today's cloud computing needs. A typical datacenter is made up of thousands of servers connected with a large network and usually managed by one operator. To provide quality access to the variety of applications and services hosted on datacenters and maximize performance, it deems necessary to use datacenter networks effectively and efficiently. Datacenter traffic is often a mix of several classes with different priorities and requirements. This includes user-generated interactive traffic, traffic with deadlines, and long-running traffic. To this end, custom transport protocols and traffic management techniques have been developed to improve datacenter network performance. In this tutorial paper, we review the general architecture of datacenter networks, various topologies proposed for them, their traffic properties, general traffic control challenges in datacenters and general traffic control objectives. The purpose of this paper is to bring out the important characteristics of traffic control in datacenters and not to survey all existing solutions (as it is virtually impossible due to massive body of existing research). We hope to provide readers with a wide range of options and factors while considering a variety of traffic control mechanisms. We discuss various characteristics of datacenter traffic control including management schemes, transmission control, traffic shaping, prioritization, load balancing, multipathing, and traffic scheduling. Next, we point to several open challenges as well as new and interesting networking paradigms. At the end of this paper, we briefly review inter-datacenter networks that connect geographically dispersed datacenters which have been receiving increasing attention recently and pose interesting and novel research problems.Comment: Accepted for Publication in IEEE Communications Surveys and Tutorial

Improving early design stage timing modeling in multicore based real-time systems

This paper presents a modelling approach for the timing behavior of real-time embedded systems (RTES) in early design phases. The model focuses on multicore processors - accepted as the next computing platform for RTES - and in particular it predicts the contention tasks suffer in the access to multicore on-chip shared resources. The model presents the key properties of not requiring the application's source code or binary and having high-accuracy and low overhead. The former is of paramount importance in those common scenarios in which several software suppliers work in parallel implementing different applications for a system integrator, subject to different intellectual property (IP) constraints. Our model helps reducing the risk of exceeding the assigned budgets for each application in late design stages and its associated costs.This work has received funding from the European Space Agency under Project Reference AO=17722=13=NL=LvH, and has also been supported by the Spanish Ministry of Science and Innovation grant TIN2015-65316-P. Jaume Abella has been partially supported by the MINECO under Ramon y Cajal postdoctoral fellowship number RYC-2013-14717.Peer ReviewedPostprint (author's final draft

Adaptive Airborne Separation to Enable UAM Autonomy in Mixed Airspace

The excitement and promise generated by Urban Air Mobility (UAM) concepts have inspired both new entrants and large aerospace companies throughout the world to invest hundreds of millions in research and development of air vehicles, both piloted and unpiloted, to fulfill these dreams. The management and separation of all these new aircraft have received much less attention, however, and even though NASAs lead is advancing some promising concepts for Unmanned Aircraft Systems (UAS) Traffic Management (UTM), most operations today are limited to line of sight with the vehicle, airspace reservation and geofencing of individual flights. Various schemes have been proposed to control this new traffic, some modeled after conventional air traffic control and some proposing fully automatic management, either from a ground-based entity or carried out on board among the vehicles themselves. Previous work has examined vehicle-based traffic management in the very low altitude airspace within a metroplex called UTM airspace in which piloted traffic is rare. A management scheme was proposed in that work that takes advantage of the homogeneous nature of the traffic operating in UTM airspace. This paper expands that concept to include a traffic management plan usable at all altitudes desired for electric Vertical Takeoff and Landing urban and short-distance, inter-city transportation. The interactions with piloted aircraft operating under both visual and instrument flight rules are analyzed, and the role of Air Traffic Control services in the postulated mixed traffic environment is covered. Separation values that adapt to each type of traffic encounter are proposed, and the relationship between required airborne surveillance range and closure speed is given. Finally, realistic scenarios are presented illustrating how this concept can reliably handle the density and traffic mix that fully implemented and successful UAM operations would entail