7 research outputs found

    Development of Gaussian Learning Algorithms for Early Detection of Alzheimer\u27s Disease

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    Alzheimer’s disease (AD) is the most common form of dementia affecting 10% of the population over the age of 65 and the growing costs in managing AD are estimated to be $259 billion, according to data reported in the 2017 by the Alzheimer\u27s Association. Moreover, with cognitive decline, daily life of the affected persons and their families are severely impacted. Taking advantage of the diagnosis of AD and its prodromal stage of mild cognitive impairment (MCI), an early treatment may help patients preserve the quality of life and slow the progression of the disease, even though the underlying disease cannot be reversed or stopped. This research aims to develop Gaussian learning algorithms, natural language processing (NLP) techniques, and mathematical models to effectively delineate the MCI participants from the cognitively normal (CN) group, and identify the most significant brain regions and patterns of changes associated with the progression of AD. The focus will be placed on the earliest manifestations of the disease (early MCI or EMCI) to plan for effective curative/therapeutic interventions and protocols. Multiple modalities of biomarkers have been found to be significantly sensitive in assessing the progression of AD. In this work, several novel multimodal classification frameworks based on proposed Gaussian Learning algorithms are created and applied to neuroimaging data. Classification based on the combination of structural magnetic resonance imaging (MRI), positron emission tomography (PET), and cerebrospinal fluid (CSF) biomarkers is seen as the most reliable approach for high-accuracy classification. Additionally, changes in linguistic complexity may provide complementary information for the diagnosis and prognosis of AD. For this research endeavor, an NLP-oriented neuropsychological assessment is developed to automatically analyze the distinguishing characteristics of text data in MCI group versus those in CN group. Early findings suggest significant linguistic differences between CN and MCI subjects in terms of word usage, vocabulary, recall, fragmented sentences. In summary, the results obtained indicate a high potential of the neuroimaging-based classification and NLP-oriented assessment to be utilized as a practically computer aided diagnosis system for classification and prediction of AD and its prodromal stages. Future work will ultimately focus on early signs of AD that could help in the planning of curative and therapeutic intervention to slow the progression of the disease

    Proceedings of the Seventh Italian Conference on Computational Linguistics CLiC-it 2020

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    On behalf of the Program Committee, a very warm welcome to the Seventh Italian Conference on Computational Linguistics (CLiC-it 2020). This edition of the conference is held in Bologna and organised by the University of Bologna. The CLiC-it conference series is an initiative of the Italian Association for Computational Linguistics (AILC) which, after six years of activity, has clearly established itself as the premier national forum for research and development in the fields of Computational Linguistics and Natural Language Processing, where leading researchers and practitioners from academia and industry meet to share their research results, experiences, and challenges

    Proceedings of the Eighth Italian Conference on Computational Linguistics CliC-it 2021

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    The eighth edition of the Italian Conference on Computational Linguistics (CLiC-it 2021) was held at UniversitĂ  degli Studi di Milano-Bicocca from 26th to 28th January 2022. After the edition of 2020, which was held in fully virtual mode due to the health emergency related to Covid-19, CLiC-it 2021 represented the first moment for the Italian research community of Computational Linguistics to meet in person after more than one year of full/partial lockdown

    Imaging neural correlates of syntactic complexity in a naturalistic context

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    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 2008.Includes bibliographical references (p. 253-280).The aim of this thesis, and the research project within which it is embedded, is to delineate a neural model of grammatical competence. For this purpose, we develop here a novel integrated, multi-disciplinary experimental paradigm that endorses the fundamental premise of generative grammar, that the study of language is in essence, the study of the mind. We use functional Magnetic Resonance Imaging (fMRI) to monitor brain activation while subjects listen to short narratives. The texts have been written so as to introduce various syntactic complexities (relative clauses, embedded questions, etc.) not usually found (in such density) in actual corpora. We have calculated a number of complexity measures (both at the level of the single word and at that of the phrase) based on current linguistic and psycholinguistic theory and with the use of a computationally implemented probabilistic parser. By correlating these measures with observed brain activity, we are able to identify the different brain networks that support linguistic processing and characterize their particular function. Conversely, we use the rich brain data to inform our cognitive, and linguistic, theory. We report here the neural correlates of surprisal (based on contextual predictions), syntactic complexity, structural ambiguity and disambiguation, Theory of Mind and non-local dependencies. This work made use of novel solutions to compute numerical predictions for these linguistic dimensions, which are often tested only qualitatively, and of a novel parametric fMRI design that allowed for the use of single subject unaveraged data as the dependent variable. The thesis ends with a synthesis of the results in the form of a blue print for a neural model of grammatical competence.by Asaf Bachrach.Ph.D

    An Initial Framework Assessing the Safety of Complex Systems

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    Trabajo presentado en la Conference on Complex Systems, celebrada online del 7 al 11 de diciembre de 2020.Atmospheric blocking events, that is large-scale nearly stationary atmospheric pressure patterns, are often associated with extreme weather in the mid-latitudes, such as heat waves and cold spells which have significant consequences on ecosystems, human health and economy. The high impact of blocking events has motivated numerous studies. However, there is not yet a comprehensive theory explaining their onset, maintenance and decay and their numerical prediction remains a challenge. In recent years, a number of studies have successfully employed complex network descriptions of fluid transport to characterize dynamical patterns in geophysical flows. The aim of the current work is to investigate the potential of so called Lagrangian flow networks for the detection and perhaps forecasting of atmospheric blocking events. The network is constructed by associating nodes to regions of the atmosphere and establishing links based on the flux of material between these nodes during a given time interval. One can then use effective tools and metrics developed in the context of graph theory to explore the atmospheric flow properties. In particular, Ser-Giacomi et al. [1] showed how optimal paths in a Lagrangian flow network highlight distinctive circulation patterns associated with atmospheric blocking events. We extend these results by studying the behavior of selected network measures (such as degree, entropy and harmonic closeness centrality)at the onset of and during blocking situations, demonstrating their ability to trace the spatio-temporal characteristics of these events.This research was conducted as part of the CAFE (Climate Advanced Forecasting of sub-seasonal Extremes) Innovative Training Network which has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 813844
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