6,209 research outputs found
Histopathological image analysis : a review
Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe
Nonparametric Feature Extraction from Dendrograms
We propose feature extraction from dendrograms in a nonparametric way. The
Minimax distance measures correspond to building a dendrogram with single
linkage criterion, with defining specific forms of a level function and a
distance function over that. Therefore, we extend this method to arbitrary
dendrograms. We develop a generalized framework wherein different distance
measures can be inferred from different types of dendrograms, level functions
and distance functions. Via an appropriate embedding, we compute a vector-based
representation of the inferred distances, in order to enable many numerical
machine learning algorithms to employ such distances. Then, to address the
model selection problem, we study the aggregation of different dendrogram-based
distances respectively in solution space and in representation space in the
spirit of deep representations. In the first approach, for example for the
clustering problem, we build a graph with positive and negative edge weights
according to the consistency of the clustering labels of different objects
among different solutions, in the context of ensemble methods. Then, we use an
efficient variant of correlation clustering to produce the final clusters. In
the second approach, we investigate the sequential combination of different
distances and features sequentially in the spirit of multi-layered
architectures to obtain the final features. Finally, we demonstrate the
effectiveness of our approach via several numerical studies
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