5,966 research outputs found

    Experiences of living and dying with Lewy body dementia:A longitudinal narrative study

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    Background Lewy body dementia is a life-limiting condition with multiple, complex symptoms. As the condition progresses much of the caring and nursing duties fall to families. However, little is known about how people with Lewy body dementia and their families are affected by the condition. The overall aim of this thesis was to explore the experiences of people living with Lewy body dementia, and their family carers over time. An integrative systematic review of the literature was conducted. A convergent integrated design was applied to facilitate the synthesis of published research exploring the experiences of people living with Lewy body dementia and family carers. There was scarce qualitative evidence identified on the lived experience, with a predominant biomedical focus and cross-sectional designs. Methodology In order to gain unique insights into people’s experiences of living with Lewy body dementia a narrative methodology was chosen. A social constructionist approach influenced the research conducted, drawing from the psycho-social discipline and experience-centred narrative theory. The underpinning perspective was that knowledge and reality are socially produced, and humans’ understanding, and interpretations of their world occurs through stories. Method A longitudinal narrative study using three sequential interviews and life story work was completed to gain unique insights into five couples’ experiences of living with Lewy body dementia. Participants were recruited from memory clinics and the ‘Join Dementia Research’ database within the east of England. Narrative data were collected using dyadic narrative interviews with each couple over a six-month period (August 2019 – Februrary 2020). The analysis of the stories was conducted using Murray’s levels of narrative analysis in health psychology. Murray’s anaytical framework enabled stories to be analysed at the personal, interpersonal, positional, and societal level. Findings The main finding from this study was that the overarching narrative of ‘social connectedness’ was found to be important, and this continued over time. In this study, social connectedness represents a stepwise description of how a person is actively involved with others and their surroundings, leading to a sense of comfort and wellbeing. Seven stages of social connectedness were identified: maintaining social connections, developing new connections together, social disconnection, support from adult children, marital disconnection, connecting to health and social care, and emotionally separated but living together. Lack of social connectedness leads to social disconnection. Repeated losses over time resulted in difficulty in maintaining social connections giving rise to a reduced sense of agency. Loss of continence, energy, and independence, together with difficulty managing medications, significantly impacted on couples’ quality of life and ability to remain connected through all stages. Conclusion Maintaining a social life and support network was important for both people living with Lewy body dementia and family carers. The findings contribute to the methodological literature that gives voice to those living with dementia over time. They highlight how physical and personality changes, communication challenges, and behavioural difficulties, undermine established social connections. The stepwise diagrammatic representation of social connectedness provides guidance for more targeted healthcare interventions and management of Lewy body dementia

    Computer Vision and Architectural History at Eye Level:Mixed Methods for Linking Research in the Humanities and in Information Technology

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    Information on the history of architecture is embedded in our daily surroundings, in vernacular and heritage buildings and in physical objects, photographs and plans. Historians study these tangible and intangible artefacts and the communities that built and used them. Thus valuableinsights are gained into the past and the present as they also provide a foundation for designing the future. Given that our understanding of the past is limited by the inadequate availability of data, the article demonstrates that advanced computer tools can help gain more and well-linked data from the past. Computer vision can make a decisive contribution to the identification of image content in historical photographs. This application is particularly interesting for architectural history, where visual sources play an essential role in understanding the built environment of the past, yet lack of reliable metadata often hinders the use of materials. The automated recognition contributes to making a variety of image sources usable forresearch.<br/

    Trends in recurrence analysis of dynamical systems

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    The last decade has witnessed a number of important and exciting developments that had been achieved for improving recurrence plot-based data analysis and to widen its application potential. We will give a brief overview about important and innovative developments, such as computational improvements, alternative recurrence definitions (event-like, multiscale, heterogeneous, and spatio-temporal recurrences) and ideas for parameter selection, theoretical considerations of recurrence quantification measures, new recurrence quantifiers (e.g. for transition detection and causality detection), and correction schemes. New perspectives have recently been opened by combining recurrence plots with machine learning. We finally show open questions and perspectives for futures directions of methodical research

    Drones, Signals, and the Techno-Colonisation of Landscape

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    This research project is a cross-disciplinary, creative practice-led investigation that interrogates increasing military interest in the electromagnetic spectrum (EMS). The project’s central argument is that painted visualisations of normally invisible aspects of contemporary EMS-enabled warfare can reveal useful, novel, and speculative but informed perspectives that contribute to debates about war and technology. It pays particular attention to how visualising normally invisible signals reveals an insidious techno-colonisation of our extended environment from Earth to orbiting satellites

    Assessment of Physical Activity in Adults with Progressive Muscle Disease

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    Introduction: Insufficient physical activity is a major threat to global health. Physical activity benefits peoples’ physical and mental health. The general population, including people living with disabilities and muscle wasting conditions, are recommended to avoid excessive sedentary time and engage in daily activity. Adults with progressive muscle disease experience barriers to physical activity participation, including muscle weakness, fatigue, physical deconditioning, impairment, activity limitations and participation restrictions (including societal and environmental factors), and fear of symptom exacerbation. More research is required to understand the inter-relationship between health and physical activity for adults with progressive muscle disease, particularly non-ambulant people who are under-represented in the existing research literature. Accurate measurement of FITT (frequency, intensity, time, and type of physical activity) is vital for high-quality physical activity assessment. The aim of this thesis was to assess the physical activity of ambulant and non-ambulant adults with progressive muscle disease.Systematic review findings identified various measures used to assess physical activity in adults with muscular dystrophy, including accelerometers, direct observation, heart rate monitors, calorimetry, positioning systems, activity diaries, single scales, interviews and questionnaires. None of the measures identified in the systematic review had well established measurement properties for adults with muscular dystrophy.Patient and public involvement interviews highlighted the importance of inclusive, remote, and technology-facilitated research design, the potential intrusion of direct observations of physical activity, the familiarity of questionnaires for data collection, and practical considerations to ensure wearing an activity monitor was not too burdensome.A feasibility study using multiple methods in 20 ambulant and non-ambulant adults with progressive muscle disease revealed satisfactory acceptability, interpretability, and usability of Fitbit and activity questionnaires, in both paper and electronic formats. During supervised activity tasks, Fitbit was found to have satisfactory criterion validity, reliability, and responsiveness and measurement properties were strengthened using multisensory measurement.An observational, longitudinal study that included 111 ambulant and non-ambulant adults with progressive muscle disease showed that:Activity monitoring had satisfactory validity, reliability and responsiveness using Fitbit, but there was considerable measurement error between Fitbit and the research grade GENEActiv accelerometer. Fitbit thresholds and multiple metrics (including accelerometer and heart rate data extrapolations of FITT) were appropriate for physical activity assessment in ambulant and non-ambulant adults with progressive muscle disease.Activity self-report had unsatisfactory concurrent validity, test-retest reliability, and responsiveness with substantial activity overestimation using the modified International Physical Activity Questionnaire. However, self-report properties were improved when used concurrently with Fitbit.Observed physical activity in adults with progressive muscle disease was generally low with excessive daily sedentary time. Activity frequencies, intensities and durations were lower, and activity types were more domestic, for wheelchair users and during the COVID-19 lockdown. Lower physical activity was significantly associated with greater functional impairment, less cardiorespiratory fitness, worse metabolic health, and lower quality of life. Activity optimisation thresholds and minimal clinically important differences were established.Discussion: The implications of this thesis include guidance for selection of appropriate physical activity measures by clinicians and researchers working with adults with progressive muscle disease. Fitbit is suitable in clinical practice and research for interactive, weekly remote activity monitoring or to support activity self-management and may represent an appropriate compromise between potential underestimation by accelerometry alone, and overestimation by self-report alone. A draft conceptual framework for physical activity measurement was also proposed. It includes frequency, intensity, time, and type of physical activity, and incorporates wider aspects of the physical activity construct, including somatic factors (relating to progressive muscle disease and underlying fitness) and contextual factors (relating to personal, social, and environmental situations). Future research will build on the knowledge gained in this thesis, furthering understanding of the inter-relationships between physical activity, health and wider contexts. Implementation will include testing a remote physical activity optimisation intervention that is inclusive of ambulant and non-ambulant participants, featuring Fitbit self-monitoring with a focus on optimisation of daily activity frequency and regularly interrupting sedentary time.</div

    Graphonomics and your Brain on Art, Creativity and Innovation : Proceedings of the 19th International Graphonomics Conference (IGS 2019 – Your Brain on Art)

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    [Italiano]: “Grafonomia e cervello su arte, creatività e innovazione”. Un forum internazionale per discutere sui recenti progressi nell'interazione tra arti creative, neuroscienze, ingegneria, comunicazione, tecnologia, industria, istruzione, design, applicazioni forensi e mediche. I contributi hanno esaminato lo stato dell'arte, identificando sfide e opportunità, e hanno delineato le possibili linee di sviluppo di questo settore di ricerca. I temi affrontati includono: strategie integrate per la comprensione dei sistemi neurali, affettivi e cognitivi in ambienti realistici e complessi; individualità e differenziazione dal punto di vista neurale e comportamentale; neuroaesthetics (uso delle neuroscienze per spiegare e comprendere le esperienze estetiche a livello neurologico); creatività e innovazione; neuro-ingegneria e arte ispirata dal cervello, creatività e uso di dispositivi di mobile brain-body imaging (MoBI) indossabili; terapia basata su arte creativa; apprendimento informale; formazione; applicazioni forensi. / [English]: “Graphonomics and your brain on art, creativity and innovation”. A single track, international forum for discussion on recent advances at the intersection of the creative arts, neuroscience, engineering, media, technology, industry, education, design, forensics, and medicine. The contributions reviewed the state of the art, identified challenges and opportunities and created a roadmap for the field of graphonomics and your brain on art. The topics addressed include: integrative strategies for understanding neural, affective and cognitive systems in realistic, complex environments; neural and behavioral individuality and variation; neuroaesthetics (the use of neuroscience to explain and understand the aesthetic experiences at the neurological level); creativity and innovation; neuroengineering and brain-inspired art, creative concepts and wearable mobile brain-body imaging (MoBI) designs; creative art therapy; informal learning; education; forensics

    Computer audition for emotional wellbeing

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    This thesis is focused on the application of computer audition (i. e., machine listening) methodologies for monitoring states of emotional wellbeing. Computer audition is a growing field and has been successfully applied to an array of use cases in recent years. There are several advantages to audio-based computational analysis; for example, audio can be recorded non-invasively, stored economically, and can capture rich information on happenings in a given environment, e. g., human behaviour. With this in mind, maintaining emotional wellbeing is a challenge for humans and emotion-altering conditions, including stress and anxiety, have become increasingly common in recent years. Such conditions manifest in the body, inherently changing how we express ourselves. Research shows these alterations are perceivable within vocalisation, suggesting that speech-based audio monitoring may be valuable for developing artificially intelligent systems that target improved wellbeing. Furthermore, computer audition applies machine learning and other computational techniques to audio understanding, and so by combining computer audition with applications in the domain of computational paralinguistics and emotional wellbeing, this research concerns the broader field of empathy for Artificial Intelligence (AI). To this end, speech-based audio modelling that incorporates and understands paralinguistic wellbeing-related states may be a vital cornerstone for improving the degree of empathy that an artificial intelligence has. To summarise, this thesis investigates the extent to which speech-based computer audition methodologies can be utilised to understand human emotional wellbeing. A fundamental background on the fields in question as they pertain to emotional wellbeing is first presented, followed by an outline of the applied audio-based methodologies. Next, detail is provided for several machine learning experiments focused on emotional wellbeing applications, including analysis and recognition of under-researched phenomena in speech, e. g., anxiety, and markers of stress. Core contributions from this thesis include the collection of several related datasets, hybrid fusion strategies for an emotional gold standard, novel machine learning strategies for data interpretation, and an in-depth acoustic-based computational evaluation of several human states. All of these contributions focus on ascertaining the advantage of audio in the context of modelling emotional wellbeing. Given the sensitive nature of human wellbeing, the ethical implications involved with developing and applying such systems are discussed throughout
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